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(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
-
-
?
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
prostaglandin E2 + NAD+
15-oxoprostaglandin E2 + NADH + H+
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
-
i.e. 15-hydroxyprostaglandin or (15S)-PGE2
-
r
(5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid + NAD+
(5Z,8E,10E)-12-oxo-5,8,10-heptadecatrienoic acid + NADH
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
15(S)-hydroperoxy-5,8,11,13-(Z,Z,Z,E)-eicosatetraenoic acid + NAD+
15-oxo-5,8,11,13-(Z,Z,Z,E)-eicosatetraenoic acid + NADH
-
-
-
-
?
15-hydroxyprostaglandin + NAD+
15-oxoprostaglandin + NADH + H+
5,6-chrysenequinone + NADH
?
-
-
-
-
?
5,6-chrysenequinone + NADH
? + H2O2
-
formation of potentially hazardous semiquinones, reaction mechanism, overview
-
-
?
6-ketoprostaglandin F1alpha + NAD+
6,15-diketoprostaglandin F1alpha + NADH + H+
-
-
-
?
9,10-phenanthrenequinone + NADH
?
-
-
-
-
?
9,10-phenanthrenequinone + NADH
? + H2O2
-
formation of potentially hazardous semiquinones, reaction mechanism, overview
-
-
?
prostaglandin A1 + NAD+
15-ketoprostaglandin A1 + NADH + H+
prostaglandin A2 + NAD+
15-ketoprostaglandin A2 + NADH + H+
prostaglandin D1 + NAD+
15-ketoprostaglandin D1 + NADH + H+
-
very low activity
-
?
prostaglandin E1 + NAD+
15-ketoprostaglandin E1 + NADH + H+
-
-
-
-
?
prostaglandin E2 + NAD+
15-ketoprostaglandin E2 + NADH + H+
prostaglandin E2 + NAD+
15-oxoprostaglandin E2 + NADH + H+
-
-
-
-
?
prostaglandin F2alpha + NAD+
15-ketoprostaglandin F2alpha + NADH + H+
prostaglandin I2 + NAD+
15-ketoprostaglandin I2 + NADH + H+
-
-
-
?
additional information
?
-
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
-
-
?
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
-
-
-
?
prostaglandin E2 + NAD+
15-oxoprostaglandin E2 + NADH + H+
-
-
-
?
prostaglandin E2 + NAD+
15-oxoprostaglandin E2 + NADH + H+
-
-
-
-
?
prostaglandin E2 + NAD+
15-oxoprostaglandin E2 + NADH + H+
-
-
-
?
prostaglandin E2 + NAD+
15-oxoprostaglandin E2 + NADH + H+
-
-
-
-
?
prostaglandin E2 + NAD+
15-oxoprostaglandin E2 + NADH + H+
-
-
-
?
prostaglandin E2 + NAD+
15-oxoprostaglandin E2 + NADH + H+
-
-
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
-
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
-
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
-
-
-
r
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
i.e. prostaglandin E1
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
i.e. prostaglandin E1
i.e. 15-ketoprostaglandin E1
r
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
catabolism of (15S)-PGE2
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
first step in prostaglandin catabolism
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
first step in prostaglnadin catabolism
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
i.e. 15-hydroxyprostaglandin or (15S)-PGE2
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
key step in prostaglandin catabolism, enzyme activation leads to reduced cell proliferation, the enzyme is an antagonist of ibuprofen
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
key step in prostaglandin inactivation
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
PGE2 degradation
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
prostaglandin E2, PGE2, a proinflammatory bioactive lipid, promotes cancer progression by modulating proliferation, apoptosis, and angiogenesis, PGE2 is a downstream product cyclooxygenase and is biochemically inactivated by the enzyme
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells, overview
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
the enzyme is a putative cyclooxygenase-2 antagonist and and tumor suppressor
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
transcriptional regulation and biological functions, the enzyme cooperates with cyclooxygenase-2 to control cellular prostaglandin levels, reciprocal regulation of the two enzymes, overview
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
i.e. 15-hydroxyprostaglandin or (15S)-PGE2, inactivation
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
i.e. 15-hydroxyprostaglandin or (15S)-PGE2, substrate binding structure analysis, determination of interactions
-
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
i.e. 15-hydroxyprostaglandin or PGE2
-
-
?
(5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid + NAD+
(5Z,8E,10E)-12-oxo-5,8,10-heptadecatrienoic acid + NADH
-
-
-
?
(5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid + NAD+
(5Z,8E,10E)-12-oxo-5,8,10-heptadecatrienoic acid + NADH
-
-
-
?
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
-
-
?
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
-
-
?
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
-
-
?
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
-
-
?
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
specific for NAD+
-
?
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
specific for NAD+
-
?
15-hydroxyprostaglandin + NAD+
15-oxoprostaglandin + NADH + H+
-
-
-
-
?
15-hydroxyprostaglandin + NAD+
15-oxoprostaglandin + NADH + H+
-
physiological inactivation of prostaglandin by catalyzing the first step in catabolism
-
?
15-hydroxyprostaglandin + NAD+
15-oxoprostaglandin + NADH + H+
-
physiological inactivation of prostaglandin by catalyzing the first step in catabolism
-
?
15-hydroxyprostaglandin + NAD+
15-oxoprostaglandin + NADH + H+
-
physiological inactivation of prostaglandin by catalyzing the first step in catabolism
-
?
prostaglandin A1 + NAD+
15-ketoprostaglandin A1 + NADH + H+
-
-
-
?
prostaglandin A1 + NAD+
15-ketoprostaglandin A1 + NADH + H+
-
-
-
?
prostaglandin A1 + NAD+
15-ketoprostaglandin A1 + NADH + H+
-
-
-
?
prostaglandin A1 + NAD+
15-ketoprostaglandin A1 + NADH + H+
-
-
-
-
?
prostaglandin A1 + NAD+
15-ketoprostaglandin A1 + NADH + H+
-
-
-
?
prostaglandin A2 + NAD+
15-ketoprostaglandin A2 + NADH + H+
-
-
-
?
prostaglandin A2 + NAD+
15-ketoprostaglandin A2 + NADH + H+
-
-
-
-
?
prostaglandin E2 + NAD+
15-ketoprostaglandin E2 + NADH + H+
-
-
-
-
?
prostaglandin E2 + NAD+
15-ketoprostaglandin E2 + NADH + H+
-
the wild type enzyme is highly active against prostaglandin E2 and NAD+
-
-
?
prostaglandin F2alpha + NAD+
15-ketoprostaglandin F2alpha + NADH + H+
-
-
-
?
prostaglandin F2alpha + NAD+
15-ketoprostaglandin F2alpha + NADH + H+
-
-
-
?
prostaglandin F2alpha + NAD+
15-ketoprostaglandin F2alpha + NADH + H+
-
-
-
?
prostaglandin F2alpha + NAD+
15-ketoprostaglandin F2alpha + NADH + H+
-
-
-
-
?
prostaglandin F2alpha + NAD+
15-ketoprostaglandin F2alpha + NADH + H+
-
specific for NAD+
-
?
prostaglandin F2alpha + NAD+
15-ketoprostaglandin F2alpha + NADH + H+
-
specific for NAD+
-
?
additional information
?
-
-
dexamethasone and phorbol ester play a role in enzyme regulation in erythroleukemia cells
-
-
?
additional information
?
-
-
key enzyme for metabolic inactivation of prostaglandins, enzyme levels are reduced in inflammatory bowel disease involving TNF-alpha
-
-
?
additional information
?
-
-
the enzyme is a tumor suppressor of human breast cancer, expression of the enzyme and the estrogen receptor is correlated, silencing of the enzyme results in enhanced cancer cell proliferation, the enzyme expression is silenced in vivo in cancer cells due to promoter methylation
-
-
?
additional information
?
-
-
the enzyme is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a medullary thyroid carcinoma cell line
-
-
?
additional information
?
-
-
15-hydroxyprostaglandin dehydrogenase may be repressed by an epigenetic mechanism involving histone deacetylation, resulting in increased prostaglandin E2 activity in tumors
-
-
?
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(1-butyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone
-
(1-phenyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone
-
(1-tert-butyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone
-
(3,3-dimethylpiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone
-
(3,5-dimethylpiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone
-
(4-bromopiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone
-
(piperidin-1-yl)[1-[3-(propan-2-yl)phenyl]-1H-benzimidazol-5-yl]methanone
-
(piperidin-1-yl)[1-[3-(trifluoromethyl)phenyl]-1H-benzimidazol-5-yl]methanone
-
(piperidin-1-yl)[1-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-5-yl]methanone
-
2-[[(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl]benzonitrile
-
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
-
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
-
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9,10,11-hexahydro-5H-[1,2,4]triazolo[4,3-a]azonine
-
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]azepine
-
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole
-
3-[1-(3,4-dichlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[1-(3-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[1-(4-bromophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[1-(4-methoxyphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[1-(4-tert-butylphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[2,5-dimethyl-1-(4-methylphenyl)-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[2,5-dimethyl-1-(4-nitrophenyl)-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[2,5-dimethyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[2,5-dimethyl-1-[4-(naphthalen-2-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[2,5-dimethyl-1-[4-(pyridin-2-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[2,5-dimethyl-1-[4-(pyridin-3-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[2,5-dimethyl-1-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[2,5-dimethyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
3-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzonitrile
-
4-((2,5-dioxopyrrolidin-3-ylidene)methyl)phenylthiophene-2-carboxylate
-
4-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzonitrile
-
5-(2-chloro-3-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(2-chloro-4-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(2-chloro-4-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(2-chloro-4-(2-cyclohexylethoxy)benzylidene)-thiazolidine-2,4-dione
-
5-(2-chloro-4-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(2-chloro-4-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione
-
5-(2-chloro-4-phenbutoxybenzylidene)thiazolidine-2,4-dione
-
5-(2-chloro-4-phenethoxybenzylidene)thiazolidine-2,4-dione
-
5-(2-chloro-4-phenpropoxybenzylidene)thiazolidine-2,4-dione
-
5-(3-chloro-4-((4-(prop-1-en-2-yl)cyclohexyl)methoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-((5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(2-(4-methyl-1,3-thiazolidin-5-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(2-(5-nitrofuran-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(2-(thiophen-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
-
5-(3-chloro-4-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(2-cyclopropylpropyl)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(2-thiomorpholine 1,1-dioxideethoxy)benzylidene)thiazolidine-2,4-dione
-
5-(3-chloro-4-(3-(2-nitroethenyl)phenoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(3-nitrophenoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(3-phenylpropoxy)benzylidene)thiazolidine-2,4-dione
-
5-(3-chloro-4-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione
-
5-(3-chloro-4-(4-phenylbutoxy)benzylidene)thiazolidine-2,4-dione
-
5-(3-chloro-4-(cyclobutylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-(cyclopentylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
5-(3-chloro-4-phenylethoxybenzylidene)thiazolidine-2,4-dione
-
5-(4-(1,3-benzodioxol-5-ylmethoxy)-3-chlorobenzylidene)-1,3-thiazolidine-2,4-dione
-
5-(4-(benzyloxy)-2-chlorobenzylidene)thiazolidine-2,4-dione
-
5-(4-(benzyloxy)-3-chlorobenzylidene)thiazolidine-2,4-dione
-
5-(4-(bicyclo[2.2.1]hept-2-ylmethoxy)-3-chlorobenzylidene)-1,3-thiazolidine-2,4-dione
-
ethyl 4-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzoate
-
N,N-diethyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide
-
N-butyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide
-
N-cyclopentyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide
-
[1-(2-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
-
[1-(3-chlorophenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
-
[1-(3-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
-
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](3-methylpiperidin-1-yl)methanone
-
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](3-phenylpiperidin-1-yl)methanone
-
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](4-methylpiperazin-1-yl)methanone
-
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](morpholin-4-yl)methanone
-
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
-
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](pyrrolidin-1-yl)methanone
-
[1-(3-methylphenyl)-1H-benzimidazol-5-yl][3-(propan-2-yl)piperidin-1-yl]methanone
-
[1-(3-methylphenyl)-1H-benzimidazol-5-yl][3-(trifluoromethyl)piperidin-1-yl]methanone
-
[1-(3-methylphenyl)-1H-benzimidazol-5-yl][4-(trifluoromethyl)piperidin-1-yl]methanone
-
[1-(3-tert-butylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
-
[1-(4-chlorophenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
-
[1-(4-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
-
[1-(4-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
-
[1-(4-tert-butylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
-
(4-([(4-chlorophenyl)sulfanyl]methyl)phenyl)(4-methylpiperidin-1-yl)methanone
-
-
(4-[(2-bromophenoxy)methyl]phenyl)(piperidin-1-yl)methanone
-
-
(5Z)-5-[3-bromo-4-(2-cyclohexylethoxy)benzylidene]-1,3-thiazolidine-2,4-dione
-
-
(5Z)-5-[3-chloro-4-(2-cyclohexylethoxy)benzylidene]-1,3-thiazolidine-2,4-dione
-
-
(5Z)-5-[3-chloro-4-(3-cyclohexylpropoxy)benzylidene]-1,3-thiazolidine-2,4-dione
-
-
(5Z)-5-[3-chloro-4-(4-cyclohexylbutoxy)benzylidene]-1,3-thiazolidine-2,4-dione
-
-
(5Z)-5-[3-chloro-4-(cyclohexylmethoxy)benzylidene]-1,3-thiazolidine-2,4-dione
-
-
(5Z)-5-[3-chloro-4-(cyclohexyloxy)benzylidene]-1,3-thiazolidine-2,4-dione
-
-
(5Z)-5-[4-(2-cyclohexylethoxy)-3-methoxybenzylidene]-1,3-thiazolidine-2,4-dione
-
-
(5Z)-5-[4-(2-cyclohexylethoxy)-3-methoxybenzylidene]-3-methyl-1,3-thiazolidine-2,4-dione
-
-
(5Z)-5-[4-(2-cyclohexylethoxy)benzylidene]-1,3-thiazolidine-2,4-dione
-
-
12-O-tetradecanoylphorbol-13-acetate
13-cis-Prostaglandin F2alpha
15-deoxy-DELTA12,14-prostaglandin J2
-
0.024 mM, 50% inhibition
15-epi-prostaglandin E1
-
-
15-Epiprostaglandin E1
-
0.17 mM, 50% inhibition
15-ketoprostaglandin E1
-
-
2-([(6-bromo-4H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl)benzonitrile
-
-
2-azido NAD+
-
photoaffinity analog of NAD+, 0.115 mM, complete inactivation
2-hydroxy-5-(3,5-dimethoxycarbonyl-benzoyl)-benzene acetic acid
-
1000 times more potent inhibitor than sulfaphasalazine
2-methyl-1,4-naphthoquinone
-
0.02 mM, time dependent inactivation
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
-
-
4,5-benzo[a]pyrenequinone
-
0.0002 mM, time dependent inactivation
4-methoxybenzyl-2,4-thiazolidinedione
-
-
4-methoxybenzylidene-2,4-thiazolidinedione
-
-
5-(4-((4-methylcyclohexyl)methoxy)benzylidene) thiazolidine-2,4-dione
-
-
5-(4-(2-(thiophen-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
-
-
5-(4-(2-(thiophen-3-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
-
-
5-(4-(2-cyclopentylethoxy)benzylidene)thiazolidine-2,4-dione
-
-
5-(4-(4-(chloromethyl)benzyloxy)benzylidene) thiazolidine-2,4-dione
-
-
5-(4-(cyclopentylmethoxy)benzylidene)thiazolidine-2,4-dione
-
-
5-[4-((1-methyl)-cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione
-
-
5-[4-((1-methyl)-cyclohexylmethoxy)benzyl]-2,4-thiazolidenedione
-
trivial name ciglitazone
5-[4-(benzoxy)benzylidene]-2,4-thiazolidenedione
-
-
5-[4-(cyclohexylbutoxy)benzylidene]-2,4-thiazolidenedione
-
-
5-[4-(cyclohexylethoxy)benzylidene]-2,4-thiazolidenedione
-
-
5-[4-(cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione
-
-
5-[4-(cyclohexyloxy)benzylidene]-2,4-thiazolidenedione
-
-
5-[4-(cyclohexylpropoxy)benzylidene]-2,4-thiazolidenedione
-
-
5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid
-
CAY-10397, specific 15-PGDH inhibitor
7,8-benzo[a]pyrenequinone
7-oxa-prostanoic acid
-
-
7-Thia-13-prostynoic acid
7-thia-prostanoic acid
-
-
Berberine
-
0.023 mM, 50% inhibition
Biochanin A
-
0.031 mM, 50% inhibition
CAY 10397
-
specific inhibitor, completely reverses the stimulating effect of ibuprofen on cell proliferation in TT cells
chalcone
-
0.016 mM, 50% inhibition
chrysin
-
0.021 mM, 50% inhibition
curcumin
-
0.01 mM, 50% inhibition
DuP 697
-
0.022 mM, 50% inhibition
ent-13-dehydro-15-epi-prostaglandin F2alpha
-
-
Ent-13-dehydro-15-epiprostaglandin F3alpha
-
0.055 mM, 50% inhibition
ent-13-dehydroprostaglandin E2
epi-7-thia-prostaglandin F2alpha
-
-
epi-7-thiaprostaglandin F2alpha
-
0.0052 mM, 50% inhibition
epigallocatechin gallate
-
0.012 mM, 50% inhibition
Flufenamic acid
-
0.041 mM, 50% inhibition
flurbiprofen
-
0.062 mM, 50% inhibition
glycerol
-
slight inhibition
hexadecanoic acid
-
0.01 mM
ketorolac
-
0.028 mM, 50% inhibition
Meclofenamic acid
-
0.073 mM, 50% inhibition
Mefenamic acid
-
0.076 mM, 50% inhibition
mixture of endogenous fatty acids
-
mixture contains palmitic acid, stearic acid linoleic acid and oleic acid, competitive vs. prostaglandine E2
-
MK 886
-
0.037 mM, 50% inhibition
N-(2-phenylethyl)-indomethacin amide
-
0.098 mM, 50% inhibition
N-(3-pyridyl)-indomethacin amide
-
0.1 mM, 50% inhibition
nat-13-dehydroprostaglandin E2
-
-
nat-13-dehydroprostaglandin F3alpha
-
-
Nat-13-thiaprostaglandin F2alpha
-
0.0088 mM, 50% inhibition
-
nat-7-thia-prostaglandin F2alpha
-
-
nat-l3-dehydroprostaglandin F2alpha
-
-
niflumic acid
-
0.058 mM, 50% inhibition
nimesulide
-
0.051 mM, 50% inhibition
NS 398
-
0.064 mM, 50% inhibition
octadecanoic acid
-
0.01 mM
PD 98059
-
an ERK kinase inhibitor
prostaglandin F2alpha
-
-
pyridoxal 5'-phosphate
-
-
resveratrol
-
0.054 mM, 50% inhibition
sulindac
-
0.041 mM, 50% inhibition
sulindac sulfide
-
0.018 mM, 50% inhibition
sulindac sulfone
-
0.038 mM, 50% inhibition
sulphasalazine
-
anticolitic drug
tetradecanoic acid
-
0.01 mM
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
-
-
[4-(4-methoxyphenyl)piperazin-1-yl](4-[(phenylsulfanyl)methyl]phenyl)methanone
-
-
1,2-naphthoquinone
-
0.0002 mM, time dependent inactivation, 1 mM glutathione or 40% glycerol protect from inactivation
1,2-naphthoquinone
-
inactivation, glutathione protects
12-O-tetradecanoylphorbol-13-acetate
-
10 nM, rapid loss of activity in eryrthroleukemia cells during 40 min, inhibition can be prevented by staurosporin indicating that protein kinase C is involved
12-O-tetradecanoylphorbol-13-acetate
-
induces the synthesis of 15-PGDH but inhibits the enzyme activity a protein kinase C mediated mechanism
13-cis-Prostaglandin F2alpha
-
-
13-cis-Prostaglandin F2alpha
-
0.124 mM, 50% inhibition
7,8-benzo[a]pyrenequinone
-
0.0002 mM, time dependent inactivation, 40% glycerol protects from inactivation
7,8-benzo[a]pyrenequinone
-
inactivation, glutathione protects
7-Oxa-13-prostynoic acid
-
-
7-Oxa-13-prostynoic acid
-
0.0475 mM, 50% inhibition
7-Thia-13-prostynoic acid
-
-
7-Thia-13-prostynoic acid
-
0.0068 mM, 50% inhibition
arachidonic acid
-
-
arachidonic acid
-
irreversible inactivation
arachidonic acid
-
0.0027 mM, 50% inhibition
ciglitazone
-
-
ciglitazone
-
0.003 mM, 50% inhibition
ent-13-dehydroprostaglandin E2
-
-
ent-13-dehydroprostaglandin E2
-
0.0068 mM, 50% inhibition
Ethacrynic acid
-
-
Ethacrynic acid
-
irreversible inactivation
Ethacrynic acid
-
0.0055 mM, 50% inhibition
ethanol
-
-
ethanol
-
slight inhibition
indomethacin
-
-
indomethacin
-
0.066 mM, 50% inhibition
Prostaglandin B1
-
-
Prostaglandin B1
-
0.0497 mM, 50% inhibition
Prostanoic acid
-
-
Prostanoic acid
-
0.013 mM, 50% inhibition
rosiglitazone
-
-
rosiglitazone
-
0.026 mM, 50% inhibition
troglitazone
-
-
troglitazone
-
0.34 mM, 50% inhibition
additional information
-
-
-
additional information
-
not inhibitited by iodoacetimide
-
additional information
-
enzyme down-regulation by estrogen
-
additional information
-
histone deacetylase inhibitors, such as sodium butyrate, scriptaid, apicidin, and oxamflatin, and transforming growth factor-beta, TGF-beta1, induce enzyme expression in lung adenocarcinoma cells, overview
-
additional information
-
IC50 values at pH 7.0 and at pH 9.0
-
additional information
-
interleukin-1beta suppresses the enzyme expression, as well as down-regulation of cyclooxygenase-2 expression, whereas down-regulation of cyclooxygenase-1 has no effect on 15-PGDH expression, overview
-
additional information
-
pH-dependent inhibition and inhibition mechanism, at high substrate concentrations there is formation of unreactive complexes between the 15-hydroxyrostaglandin and both the free enzyme and enzyme-NADH complex and between the 15-ketoprostaglandin and both the free enzyme and enzyme NAD+ complex
-
additional information
-
the enzyme expression is suppressed by the epidermal growth factor via snail which interacts through its zinc finger structure, mechanism overview
-
additional information
-
TNF-alpha suppresses the enzyme expression in colonocytes
-
additional information
-
bile acids activate the signal transduction pathway protein kinase C-> extracellular signal-regulated kinase 1/2-> early growth response factor-1-> Snail and thereby suppress 15-PGDH transcription, unconjugated bile acids are much more potent inhibitors of 15-PGDH expression and activity than related conjugated bile acids, chenodeoxycholate and deoxycholate suppress the transcription of 15-PGDH resulting in reduced amounts of mRNA, protein, and enzyme activity
-
additional information
-
histone deacetylase 2 and the transcriptional regulator Snail play a central role in the suppression of 15-PGDH expression
-
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Aberrant Crypt Foci
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Aberrant Crypt Foci
Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and 15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led to prevention of colitis-associated cancer.
Abortion, Spontaneous
Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD-/-) mice due to requirement for embryo 15-HPGD activity.
Acromegaly
Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver.
Acute Kidney Injury
15-Hydroxyprostaglandin dehydrogenase inhibitor prevents contrast-induced acute kidney injury.
Acute Kidney Injury
Pharmacologic Blockade of 15-PGDH Protects Against Acute Renal Injury Induced by LPS in Mice.
Adenocarcinoma
11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid.
Adenocarcinoma
15-Hydroxyprostaglandin dehydrogenase as a marker in colon carcinogenesis: analysis of the prostaglandin pathway in human colonic tissue.
Adenocarcinoma
15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer.
Adenocarcinoma
Correlation of 15-prostagladin dehydrogenase expression with clinicopathological factors and survival rate in gastric adenocarcinoma.
Adenocarcinoma
Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.
Adenocarcinoma
MicroRNA-21 induces loss of 15-hydroxyprostaglandin dehydrogenase in early gastric tubular adenocarcinoma.
Adenocarcinoma
Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma.
Adenocarcinoma
Relationship between 15-hydroxyprostaglandin dehydrogenase and gastric adenocarcinoma.
Adenocarcinoma of Lung
15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer.
Adenocarcinoma of Lung
15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells.
Adenocarcinoma of Lung
Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells.
Adenocarcinoma of Lung
Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells.
Adenoma
15-Hydroxyprostaglandin dehydrogenase as a marker in colon carcinogenesis: analysis of the prostaglandin pathway in human colonic tissue.
Adenoma
15-hydroxyprostaglandin dehydrogenase in colorectal mucosa as a potential biomarker for predicting colorectal neoplasms.
Adenoma
15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors.
Adenoma
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Adenoma
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer.
Adenoma
?-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.
Adenoma
Chemopreventive Efficacy of the Cyclooxygenase-2 (Cox-2) Inhibitor, Celecoxib, Is Predicted by Adenoma Expression of Cox-2 and 15-PGDH.
Adenoma
Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.
Adenoma
Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor suppressor role in pituitary adenomas.
Adenoma
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer.
Adenoma
Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs.
Adenomatous Polyposis Coli
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Amyotrophic Lateral Sclerosis
Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis.
Anaphylaxis
PGE2 deficiency predisposes to anaphylaxis by causing mast cell hyperresponsiveness.
Aortic Aneurysm, Abdominal
Expression and Cellular Localization of 15-Hydroxy-Prostaglandin-Dehydrogenase in Abdominal Aortic Aneurysm.
Arthritis
Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue.
Arthritis, Rheumatoid
15-hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes.
Arthritis, Rheumatoid
Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue.
Bone Marrow Failure Disorders
Inhibition of 15-PGDH Protects Mice from Immune-Mediated Bone Marrow Failure.
Breast Neoplasms
15-Deoxy-?12,14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 cells.
Breast Neoplasms
15-Deoxy-?12,14-prostaglandin J2 upregulates the expression of 15-hydroxyprostaglandin dehydrogenase through DNA methyltransferase 1 inactivation.
Breast Neoplasms
15-Hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells.
Breast Neoplasms
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer.
Breast Neoplasms
15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma.
Breast Neoplasms
Celecoxib enhances the efficacy of 15-hydroxyprostaglandin dehydrogenase gene therapy in treating murine breast cancer.
Breast Neoplasms
Cigarette Smoke Regulates Calcium-Independent Phospholipase A2 Metabolic Pathways in Breast Cancer.
Breast Neoplasms
Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ER?-positive breast cancer.
Breast Neoplasms
Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer.
Breast Neoplasms
Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer.
Breast Neoplasms
Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer.
Breast Neoplasms
Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells.
Breast Neoplasms
Oncolytic herpes simplex virus 1 encoding 15-prostaglandin dehydrogenase mitigates immune suppression and reduces ectopic primary and metastatic breast cancer in mice.
Breast Neoplasms
Prostaglandin metabolising enzymes and PGE2 are inversely correlated with vitamin D receptor and 25(OH)2D3 in breast cancer.
Breast Neoplasms
Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaglandin metabolism in breast cancer cells.
Breast Neoplasms
Upregulation of Cyclooxygenase-2/Prostaglandin E2 (COX-2/PGE2) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer.
Carcinogenesis
15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer.
Carcinogenesis
15-Hydroxyprostaglandin dehydrogenase as a marker in colon carcinogenesis: analysis of the prostaglandin pathway in human colonic tissue.
Carcinogenesis
15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy.
Carcinogenesis
15-hydroxyprostaglandin dehydrogenase in colorectal mucosa as a potential biomarker for predicting colorectal neoplasms.
Carcinogenesis
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.
Carcinogenesis
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human gastric cancer.
Carcinogenesis
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Carcinogenesis
15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer.
Carcinogenesis
15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice.
Carcinogenesis
15-PGDH Expression in Gastric Cancer: A Potential Role in Anti-Tumor Immunity.
Carcinogenesis
5-aminosalicylic acid mediates expression of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase to suppress colorectal tumorigenesis.
Carcinogenesis
?-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.
Carcinogenesis
Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes.
Carcinogenesis
Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells.
Carcinogenesis
Correlation of 15-prostagladin dehydrogenase expression with clinicopathological factors and survival rate in gastric adenocarcinoma.
Carcinogenesis
Curcumin induces expression of 15-hydroxyprostaglandin dehydrogenase in gastric mucosal cells and mouse stomach in vivo: AP-1 as a potential target.
Carcinogenesis
Expression of 15-PGDH is downregulated by COX-2 in gastric cancer.
Carcinogenesis
Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer.
Carcinogenesis
Inflammation Modulation by Vitamin D and Calcium in the Morphologically Normal Colorectal Mucosa of Colorectal Adenoma Patients in a Clinical Trial.
Carcinogenesis
Inhibition of 15-Hydroxyprostaglandin Dehydrogenase by Helicobacter pylori in Human Gastric Carcinogenesis.
Carcinogenesis
MicroRNA-21 induces loss of 15-hydroxyprostaglandin dehydrogenase in early gastric tubular adenocarcinoma.
Carcinogenesis
miR-21 modulates prostaglandin signaling and promotes gastric tumorigenesis by targeting 15-PGDH.
Carcinogenesis
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
Carcinogenesis
Nuclear Factor Erythroid 2-related Factor 2 Knockout Suppresses the Development of Aggressive Colorectal Cancer Formation Induced by Azoxymethane/Dextran Sulfate Sodium-Treatment in Female Mice.
Carcinogenesis
Suppression of invasive properties of colorectal carcinoma SW480 cells by 15-hydroxyprostaglandin dehydrogenase gene.
Carcinogenesis
Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
Carcinogenesis
The ?-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of ?-catenin complex, inhibiting COX-2 through repressing NF-?B, and inducing 15-prostaglandin dehydrogenase.
Carcinogenesis
The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.
Carcinoma
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Carcinoma
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer.
Carcinoma
15-PGDH is reduced and induces apoptosis and cell cycle arrest in gastric carcinoma.
Carcinoma
?-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.
Carcinoma
Altered expression of 15-hydroxyprostaglandin dehydrogenase in tumor-infiltrated CD11b myeloid cells: a mechanism for immune evasion in cancer.
Carcinoma
Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia.
Carcinoma
Decreased expression of 15-hydroxyprostaglandin dehydrogenase in gastric carcinomas.
Carcinoma
Effect of 15-hydroxyprostaglandin dehydrogenase gene on the proliferation of gastric cancer cell murine forestomach carcinoma.
Carcinoma
Experimental cancer therapy using restoration of NAD+ -linked 15-hydroxyprostaglandin dehydrogenase expression.
Carcinoma
Expression of 15-hydroxyprostaglandin dehydrogenase, a COX-2 antagonist and tumour suppressor, is not altered in gastric carcinomas.
Carcinoma
Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH(2))D(3)) and prostaglandin E(2) (PGE(2)) serum level in ovarian cancer patients.
Carcinoma
MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma.
Carcinoma
Molecular pathology of breast apocrine carcinomas: a protein expression signature specific for benign apocrine metaplasia.
Carcinoma, Hepatocellular
15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPAR?-mediated activation of p21(WAF1/Cip1.)
Carcinoma, Hepatocellular
Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Role of 15-hydroxyprostaglandin dehydrogenase down-regulation on the prognosis of hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis.
Carcinoma, Non-Small-Cell Lung
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer.
Carcinoma, Squamous Cell
MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma.
Cholangiocarcinoma
?-3 polyunsaturated fatty acids upregulate 15-PGDH expression in cholangiocarcinoma cells by inhibiting miR-26a/b expression.
Cholangiocarcinoma
Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids.
Cholangiocarcinoma
MiR-21 Targets 15-PGDH and Promotes Cholangiocarcinoma Growth.
Chordoma
Aberrant Expression of Extracellular Signal-Regulated Kinase and 15-Hydroxyprostaglandin Dehydrogenase Indicates Radiation Resistance and Poor Prognosis for Patients with Clival Chordomas.
Choriocarcinoma
Nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase activity in hydatidiform mole tissue and choriocarcinoma cells.
Colitis
Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and 15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led to prevention of colitis-associated cancer.
Colitis
Damage control: Harnessing prostaglandin E2 as a potential healing factor of tissue injuries.
Colitis
Resolution of Cox mediated inflammation by Se supplementation in mouse experimental model of colitis.
Colitis, Ulcerative
Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair.
Colitis, Ulcerative
Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha.
Colitis-Associated Neoplasms
Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and 15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led to prevention of colitis-associated cancer.
Colitis-Associated Neoplasms
Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition.
Colitis-Associated Neoplasms
Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
Colonic Neoplasms
15-Deoxy-?12,14-prostaglandin J2 Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells.
Colonic Neoplasms
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells.
Colonic Neoplasms
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.
Colonic Neoplasms
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Colonic Neoplasms
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.
Colonic Neoplasms
15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells.
Colonic Neoplasms
15-PGDH regulated PD-1/PD-L1 immune checkpoint blockade immunotherapy in colon cancer is a TNF-? dependent phenomenon.
Colonic Neoplasms
A potential anti-tumor effect of leukotriene C4 through the induction of 15-hydroxyprostaglandin dehydrogenase expression in colon cancer cells.
Colonic Neoplasms
Anti-angiogenic action of leukotriene-C4 induced 15-hydroxyprostaglandin dehydrogenase in colon cancer cells is a TNF-? dependent phenomenon.
Colonic Neoplasms
Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line.
Colonic Neoplasms
Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes.
Colonic Neoplasms
Cyclooxygenase-2 knockdown by RNA interference in colon cancer.
Colonic Neoplasms
Erratum: 15-Deoxy-?12,14-prostaglandin J2 Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells.
Colonic Neoplasms
Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility.
Colonic Neoplasms
miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.
Colonic Neoplasms
Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells.
Colonic Neoplasms
Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).
Colonic Neoplasms
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer.
Colonic Neoplasms
Single nucleotide polymorphism rs2555639 in 15-PGDH and colorectal cancer metastasis.
Colonic Neoplasms
Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs.
Colonic Neoplasms
Suppression of invasive properties of colorectal carcinoma SW480 cells by 15-hydroxyprostaglandin dehydrogenase gene.
Colonic Neoplasms
Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition.
Colonic Neoplasms
Tumour-suppressive effect of oestrogen receptor ? in colorectal cancer patients, colon cancer cells, and a zebrafish model.
Colonic Neoplasms
[Role of prostaglandins in colon cancer]
Colorectal Neoplasms
15-hydroxyprostaglandin dehydrogenase in colorectal mucosa as a potential biomarker for predicting colorectal neoplasms.
Colorectal Neoplasms
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer.
Colorectal Neoplasms
15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice.
Colorectal Neoplasms
5-aminosalicylic acid mediates expression of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase to suppress colorectal tumorigenesis.
Colorectal Neoplasms
?-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?
Colorectal Neoplasms
?-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.
Colorectal Neoplasms
Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD).
Colorectal Neoplasms
Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation.
Colorectal Neoplasms
Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer.
Colorectal Neoplasms
HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells.
Colorectal Neoplasms
HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells.
Colorectal Neoplasms
Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer.
Colorectal Neoplasms
Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells.
Colorectal Neoplasms
Prognostic implication of 15-hydroxyprostaglandin dehydrogenase down-regulation in patients with colorectal cancer.
Colorectal Neoplasms
Regulation of prostaglandin transporters in colorectal neoplasia.
Colorectal Neoplasms
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer.
Colorectal Neoplasms
Single nucleotide polymorphism rs2555639 in 15-PGDH and colorectal cancer metastasis.
Colorectal Neoplasms
Suppression of invasive properties of colorectal carcinoma SW480 cells by 15-hydroxyprostaglandin dehydrogenase gene.
Colorectal Neoplasms
Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition.
Coronary Stenosis
Prostaglandin E2 (PGE2) synthesis pathway is involved in coronary artery stenosis and restenosis.
Crohn Disease
Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha.
Cysts
Apocrine cysts of the breast: biomarkers, origin, enlargement, and relation with cancer phenotype.
Ductus Arteriosus, Patent
Effect of dexamethasone on fetal lung 15-hydroxy-prostaglandin dehydrogenase: possible mechanism for the prevention of patent ductus arteriosus by maternal dexamethasone therapy.
Endometriosis
Expression of eicosanoid biosynthetic and catabolic enzymes in peritoneal endometriosis.
Esophageal Neoplasms
Expression of PGDH Correlates with Cell Growth in Both Esophageal Squamous Cell Carcinoma and Adenocarcinoma.
Gastritis
15-Hydroxyprostaglandin Dehydrogenase is Downregulated and Exhibits Tumor Suppressor Activity in Gastric Cancer.
Gastrointestinal Neoplasms
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.
Gastrointestinal Neoplasms
Inhibition of 15-Hydroxyprostaglandin Dehydrogenase by Helicobacter pylori in Human Gastric Carcinogenesis.
Glioblastoma
Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenase.
Glioblastoma
Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).
Glioma
Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenase.
Herpes Simplex
Oncolytic herpes simplex virus 1 encoding 15-prostaglandin dehydrogenase mitigates immune suppression and reduces ectopic primary and metastatic breast cancer in mice.
Hydatidiform Mole
Nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase activity in hydatidiform mole tissue and choriocarcinoma cells.
Hypertension
15-Hydroxyprostaglandin dehydrogenase.
Hypertension
Kidney 15-hydroxy-prostaglandin-dehydrogenase activity during the development of experimental hypertension in the rat.
Hypertension
Renal prostaglandin excretion and metabolism in male and female New Zealand normotensive and genetically hypertensive rats.
Hypertension, Pulmonary
15-PGDH/15-KETE plays a role in hypoxia-induced pulmonary vascular remodeling through ERK1/2-dependent PAR-2 pathway.
Hyperthyroidism
Experimental hyperthyroidism in rats suppresses in vitro prostaglandin metabolism in lung and kidney.
Infections
15-hydroxyprostaglandin dehydrogenase: implications in preterm labor with and without ascending infection.
Infections
Immunoreactive 15-hydroxyprostaglandin dehydrogenase (PGDH) is reduced in fetal membranes from patients at preterm delivery in the presence of infection.
Infections
Inhibition of 15-Hydroxyprostaglandin Dehydrogenase by Helicobacter pylori in Human Gastric Carcinogenesis.
Infections
Localization of prostaglandin H synthase, prostaglandin dehydrogenase, corticotropin releasing hormone and glucocorticoid receptor in rhesus monkey fetal membranes with labor and in the presence of infection.
Infections
Oncolytic herpes simplex virus 1 encoding 15-prostaglandin dehydrogenase mitigates immune suppression and reduces ectopic primary and metastatic breast cancer in mice.
Infections
[Spontaneous premature birth: physiopathology, predictors and management. The frequency is constant--early detection can improve therapeutic possibilities]
Inflammatory Bowel Diseases
Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha.
Intestinal Polyposis
Endogenous conversion of ?-6 to ?-3 polyunsaturated fatty acids in fat-1 mice attenuated intestinal polyposis by either inhibiting COX-2/?-catenin signaling or activating 15-PGDH/IL-18.
Intracranial Aneurysm
Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice.
Intracranial Aneurysm
Sex Differential in 15-Hydroxyprostaglandin Dehydrogenase Levels in the Lumen of Human Intracranial Aneurysms.
Leukemia
Effect of two antiprogestins (mifepristone and onapristone) on endometrial factors of potential importance for implantation.
Leukemia
Metabolism of cyclooxygenase and lipoxygenase products by 15-prostaglandin dehydrogenase from human HL-60 leukemia cells.
Lung Diseases
Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-?.
Lung Neoplasms
15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer.
Lung Neoplasms
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.
Lung Neoplasms
Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells.
Lung Neoplasms
Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis.
Lung Neoplasms
Focusing downstream in lung cancer prevention: 15-hydroxyprostaglandin dehydrogenase.
Lung Neoplasms
Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer.
Lung Neoplasms
Interleukin-4 up-regulates 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human lung cancer cells.
Lung Neoplasms
Interleukin-4 UP-regulates 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human lung cancer cells.
Lung Neoplasms
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer.
Lung Neoplasms
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
Lung Neoplasms
Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase.
Lung Neoplasms
Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).
Lymphatic Metastasis
15-PGDH expression as a predictive factor response to neoadjuvant chemotherapy in advanced gastric cancer.
Lymphatic Metastasis
15-PGDH Expression in Gastric Cancer: A Potential Role in Anti-Tumor Immunity.
Lymphatic Metastasis
Downregulation of 15-hydroxyprostaglandin dehydrogenase by interleukin-1? from activated macrophages leads to poor prognosis in pancreatic cancer.
Lymphatic Metastasis
Expression of 15-PGDH is downregulated by COX-2 in gastric cancer.
Muscular Atrophy
15-PGDH: a potential target for the treatment of muscle atrophy.
Muscular Atrophy
Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.
Neoplasm Metastasis
15-PGDH expression as a predictive factor response to neoadjuvant chemotherapy in advanced gastric cancer.
Neoplasm Metastasis
15-PGDH Expression in Gastric Cancer: A Potential Role in Anti-Tumor Immunity.
Neoplasm Metastasis
Celecoxib enhances the efficacy of 15-hydroxyprostaglandin dehydrogenase gene therapy in treating murine breast cancer.
Neoplasm Metastasis
Correlation of 15-prostagladin dehydrogenase expression with clinicopathological factors and survival rate in gastric adenocarcinoma.
Neoplasm Metastasis
Decreased expression of 15-hydroxyprostaglandin dehydrogenase in gastric carcinomas.
Neoplasm Metastasis
Downregulation of 15-hydroxyprostaglandin dehydrogenase by interleukin-1? from activated macrophages leads to poor prognosis in pancreatic cancer.
Neoplasm Metastasis
Expression of 15-PGDH is downregulated by COX-2 in gastric cancer.
Neoplasm Metastasis
Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer.
Neoplasm Metastasis
Oncolytic herpes simplex virus 1 encoding 15-prostaglandin dehydrogenase mitigates immune suppression and reduces ectopic primary and metastatic breast cancer in mice.
Neoplasm Metastasis
Regional differences in prostaglandin E2 metabolism in human colorectal cancer liver metastases.
Neoplasm Metastasis
Single nucleotide polymorphism rs2555639 in 15-PGDH and colorectal cancer metastasis.
Neoplasm Metastasis
Suppression of invasive properties of colorectal carcinoma SW480 cells by 15-hydroxyprostaglandin dehydrogenase gene.
Neoplasms
15-Deoxy-?12,14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 cells.
Neoplasms
15-Deoxy-?12,14-prostaglandin J2 upregulates the expression of 15-hydroxyprostaglandin dehydrogenase through DNA methyltransferase 1 inactivation.
Neoplasms
15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer.
Neoplasms
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells.
Neoplasms
15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy.
Neoplasms
15-hydroxyprostaglandin dehydrogenase in colorectal mucosa as a potential biomarker for predicting colorectal neoplasms.
Neoplasms
15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors.
Neoplasms
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.
Neoplasms
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer.
Neoplasms
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human gastric cancer.
Neoplasms
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Neoplasms
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer.
Neoplasms
15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer.
Neoplasms
15-Hydroxyprostaglandin Dehydrogenase is Downregulated and Exhibits Tumor Suppressor Activity in Gastric Cancer.
Neoplasms
15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice.
Neoplasms
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.
Neoplasms
15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells.
Neoplasms
15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPAR?-mediated activation of p21(WAF1/Cip1.)
Neoplasms
?-3 polyunsaturated fatty acids upregulate 15-PGDH expression in cholangiocarcinoma cells by inhibiting miR-26a/b expression.
Neoplasms
?-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?
Neoplasms
?-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.
Neoplasms
A nonrandomized trial of vitamin D supplementation for Barrett's esophagus.
Neoplasms
A potential anti-tumor effect of leukotriene C4 through the induction of 15-hydroxyprostaglandin dehydrogenase expression in colon cancer cells.
Neoplasms
Advances in the biology of lung cancer chemoprevention.
Neoplasms
Altered expression of 15-hydroxyprostaglandin dehydrogenase in tumor-infiltrated CD11b myeloid cells: a mechanism for immune evasion in cancer.
Neoplasms
Apocrine cysts of the breast: biomarkers, origin, enlargement, and relation with cancer phenotype.
Neoplasms
Apricoxib upregulates 15-PGDH and PGT in tobacco-related epithelial malignancies.
Neoplasms
Breast cancer--new aspects of tumor biology: are calcitriol and cyclooxygenase-2 possible targets for breast cancer?
Neoplasms
Celecoxib enhances the efficacy of 15-hydroxyprostaglandin dehydrogenase gene therapy in treating murine breast cancer.
Neoplasms
Chemopreventive Efficacy of the Cyclooxygenase-2 (Cox-2) Inhibitor, Celecoxib, Is Predicted by Adenoma Expression of Cox-2 and 15-PGDH.
Neoplasms
Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation.
Neoplasms
Colonic 15-PGDH Levels Are Stable Across Distance and Time and Are Not Perturbed by Aspirin Intervention.
Neoplasms
Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and 15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led to prevention of colitis-associated cancer.
Neoplasms
Correlation of 15-prostagladin dehydrogenase expression with clinicopathological factors and survival rate in gastric adenocarcinoma.
Neoplasms
Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers.
Neoplasms
Decreased expression of 15-hydroxyprostaglandin dehydrogenase in gastric carcinomas.
Neoplasms
Decreased systemic IGF-1 in response to calorie restriction modulates murine tumor cell growth, nuclear factor-?B activation, and inflammation-related gene expression.
Neoplasms
Dietary intake of fermented kimchi prevented colitis-associated cancer.
Neoplasms
Dietary intake of walnut prevented Helicobacter pylori-associated gastric cancer through rejuvenation of chronic atrophic gastritis.
Neoplasms
Downregulation of 15-hydroxyprostaglandin dehydrogenase by interleukin-1? from activated macrophages leads to poor prognosis in pancreatic cancer.
Neoplasms
Effect of 15-hydroxyprostaglandin dehydrogenase gene on the proliferation of gastric cancer cell murine forestomach carcinoma.
Neoplasms
Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor.
Neoplasms
Enhancement of experimental colon cancer by genistein.
Neoplasms
Experimental cancer therapy using restoration of NAD+ -linked 15-hydroxyprostaglandin dehydrogenase expression.
Neoplasms
Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis.
Neoplasms
Expression of 15-hydroxyprostaglandin dehydrogenase, a COX-2 antagonist and tumour suppressor, is not altered in gastric carcinomas.
Neoplasms
Expression of 15-PGDH is downregulated by COX-2 in gastric cancer.
Neoplasms
Expression of prostaglandin- and vitamin D-metabolising enzymes in benign and malignant breast cells.
Neoplasms
Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH(2))D(3)) and prostaglandin E(2) (PGE(2)) serum level in ovarian cancer patients.
Neoplasms
Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells.
Neoplasms
Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer.
Neoplasms
Indomethacin, a COX inhibitor, enhances 15-PGDH and decreases human tumoral C cells proliferation.
Neoplasms
Indomethacin, a cox inhibitor, enhances 15-PGDH and decreases human tumoral C cells proliferation.
Neoplasms
Inhibition of 15-Hydroxyprostaglandin Dehydrogenase by Helicobacter pylori in Human Gastric Carcinogenesis.
Neoplasms
Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.
Neoplasms
Interleukin-10 modifies the effects of interleukin-1beta and tumor necrosis factor-alpha on the activity and expression of prostaglandin H synthase-2 and the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase in cultured term human villous trophoblast and chorion trophoblast cells.
Neoplasms
Loss of 15-hydroxyprostaglandin dehydrogenase expression contributes to bladder cancer progression.
Neoplasms
Loss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumors.
Neoplasms
Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor suppressor role in pituitary adenomas.
Neoplasms
Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.
Neoplasms
MicroRNA-21 induces loss of 15-hydroxyprostaglandin dehydrogenase in early gastric tubular adenocarcinoma.
Neoplasms
miR-21 modulates prostaglandin signaling and promotes gastric tumorigenesis by targeting 15-PGDH.
Neoplasms
MiR-21 Targets 15-PGDH and Promotes Cholangiocarcinoma Growth.
Neoplasms
miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.
Neoplasms
miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin dehydrogenase (HPGD).
Neoplasms
Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer.
Neoplasms
Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer.
Neoplasms
Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer.
Neoplasms
NAD(+)-Linked 15-Hydroxyprostaglandin Dehydrogenase: Structure and Biological Functions.
Neoplasms
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer.
Neoplasms
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
Neoplasms
Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells.
Neoplasms
Nuclear Factor Erythroid 2-related Factor 2 Knockout Suppresses the Development of Aggressive Colorectal Cancer Formation Induced by Azoxymethane/Dextran Sulfate Sodium-Treatment in Female Mice.
Neoplasms
Oncolytic herpes simplex virus 1 encoding 15-prostaglandin dehydrogenase mitigates immune suppression and reduces ectopic primary and metastatic breast cancer in mice.
Neoplasms
Prognostic implication of 15-hydroxyprostaglandin dehydrogenase down-regulation in patients with colorectal cancer.
Neoplasms
Prostaglandin catabolic enzymes as tumor suppressors.
Neoplasms
Prostaglandin E2 Pathway Is Dysregulated in Gastric Adenocarcinoma in a Caucasian Population.
Neoplasms
Prostaglandin metabolizing enzymes in correlation with vitamin D receptor in benign and malignant breast cell lines.
Neoplasms
Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma.
Neoplasms
Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).
Neoplasms
Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma.
Neoplasms
Regulation of prostaglandin transporters in colorectal neoplasia.
Neoplasms
Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression.
Neoplasms
ROS-Mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD
Neoplasms
Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs.
Neoplasms
Suppressed Helicobacter pylori-associated gastric tumorigenesis in Fat-1 transgenic mice producing endogenous ?-3 polyunsaturated fatty acids.
Neoplasms
Suppression of invasive properties of colorectal carcinoma SW480 cells by 15-hydroxyprostaglandin dehydrogenase gene.
Neoplasms
Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
Neoplasms
The effect of tumor necrosis factor ? (TNF?), interleukin 1? (IL1?) and interleukin 6 (IL6) on endometrial PGF2? synthesis, metabolism and release in early-pregnant pigs.
Neoplasms
The first case of primary hypertrophic osteoarthropathy with soft tissue giant tumors caused by HPGD loss-of-function mutation.
Neoplasms
Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver.
Neoplasms
Tumor growth inhibition by indomethacin in a mouse model of human medullary thyroid cancer: implication of cyclooxygenases and 15-hydroxyprostaglandin dehydrogenase.
Neoplasms
Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition.
Neoplasms
Upregulation of Prostaglandin E2 by Inducible Microsomal Prostaglandin E Synthase-1 in Colon Cancer.
Neoplasms, Multiple Primary
15-hydroxyprostaglandin dehydrogenase in colorectal mucosa as a potential biomarker for predicting colorectal neoplasms.
Niemann-Pick Diseases
Identification of luminal and secreted proteins in bull epididymis.
Obstetric Labor, Premature
15-hydroxyprostaglandin dehydrogenase and cyclooxygenase 2 messenger ribonucleic acid expression and immunohistochemical localization in human cervical tissue during term and preterm labor.
Obstetric Labor, Premature
15-hydroxyprostaglandin dehydrogenase: implications in preterm labor with and without ascending infection.
Obstetric Labor, Premature
Immunohistochemical localization, messenger ribonucleic acid abundance, and activity of 15-hydroxyprostaglandin dehydrogenase in placenta and fetal membranes during term and preterm labor.
Obstetric Labor, Premature
Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.
Obstetric Labor, Premature
Reduced Expression of Hydrogen Sulfide-Generating Enzymes Down-Regulates 15-Hydroxyprostaglandin Dehydrogenase in Chorion during Term and Preterm Labor.
Obstetric Labor, Premature
[Expression of cyclooxygenase-2 and 15-prostaglandin dehydrogenase of placenta and fetal membranes in patients of preterm labor]
Osteoarthropathy, Primary Hypertrophic
A novel homozygous splice site mutation in the HPGD gene causes mild primary hypertrophic osteoarthropathy.
Osteoarthropathy, Primary Hypertrophic
A novel recessive 15-hydroxyprostaglandin dehydrogenase mutation in a family with primary hypertrophic osteoarthropathy.
Osteoarthropathy, Primary Hypertrophic
Common and recurrent HPGD mutations in Caucasian individuals with primary hypertrophic osteoarthropathy.
Osteoarthropathy, Primary Hypertrophic
Complete form of pachydermoperiostosis: A case report.
Osteoarthropathy, Primary Hypertrophic
Establishment of a novel human iPSC line (SDQLCHi032-A) derived from a patient with primary hypertrophic osteoarthropathy caused by HPGD homozygous mutation.
Osteoarthropathy, Primary Hypertrophic
Homozygous mutations in the 15-hydroxyprostaglandin dehydrogenase gene in patients with primary hypertrophic osteoarthropathy.
Osteoarthropathy, Primary Hypertrophic
HPGD mutations cause cranioosteoarthropathy but not autosomal dominant digital clubbing.
Osteoarthropathy, Primary Hypertrophic
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy.
Ovarian Neoplasms
Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH(2))D(3)) and prostaglandin E(2) (PGE(2)) serum level in ovarian cancer patients.
Pancreatic Neoplasms
Downregulation of 15-hydroxyprostaglandin dehydrogenase by interleukin-1? from activated macrophages leads to poor prognosis in pancreatic cancer.
Peptic Ulcer
15-PGDH inhibitors: the antiulcer effects of carbenoxolone, pioglitazone and verapamil in indomethacin induced peptic ulcer rats.
Pituitary Neoplasms
Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor suppressor role in pituitary adenomas.
Pituitary Neoplasms
Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver.
Pre-Eclampsia
Decreased gene expression of 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase in human placenta of patients with preeclampsia.
Pre-Eclampsia
In vitro activity of nicotinamide adenine dinucleotide- and nicotinamide adenine dinucleotide phosphate-linked 15-hydroxyprostaglandin dehydrogenases in placentas from normotensive and preeclamptic/eclamptic pregnancies.
Premature Birth
Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.
Premature Birth
Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.
Premature Birth
[Spontaneous premature birth: physiopathology, predictors and management. The frequency is constant--early detection can improve therapeutic possibilities]
Prolactinoma
Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor suppressor role in pituitary adenomas.
Prostatic Neoplasms
Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells.
Prostatic Neoplasms
Synergistic induction of the nicotinamide adenine dinucleotide-linked 15-hydroxyprostaglandin dehydrogenase by an androgen and interleukin-6 or forskolin in human prostate cancer cells.
Pulmonary Fibrosis
Inhibiting eicosanoid degradation exerts antifibrotic effects in a pulmonary fibrosis mouse model and human tissue.
Pulmonary Fibrosis
Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis.
Sarcopenia
Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.
Schistosomiasis
Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder.
Severe Combined Immunodeficiency
15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPAR?-mediated activation of p21(WAF1/Cip1.)
Skin Neoplasms
UV radiation inhibits 15-hydroxyprostaglandin dehydrogenase levels in human skin: evidence of transcriptional suppression.
Squamous Cell Carcinoma of Head and Neck
Apricoxib upregulates 15-PGDH and PGT in tobacco-related epithelial malignancies.
Stomach Neoplasms
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human gastric cancer.
Stomach Neoplasms
15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer.
Stomach Neoplasms
15-Hydroxyprostaglandin Dehydrogenase is Downregulated and Exhibits Tumor Suppressor Activity in Gastric Cancer.
Stomach Neoplasms
15-PGDH expression as a predictive factor response to neoadjuvant chemotherapy in advanced gastric cancer.
Stomach Neoplasms
15-PGDH Expression in Gastric Cancer: A Potential Role in Anti-Tumor Immunity.
Stomach Neoplasms
15-PGDH is reduced and induces apoptosis and cell cycle arrest in gastric carcinoma.
Stomach Neoplasms
Effect of 15-hydroxyprostaglandin dehydrogenase gene on the proliferation of gastric cancer cell murine forestomach carcinoma.
Stomach Neoplasms
Expression of 15-PGDH is downregulated by COX-2 in gastric cancer.
Stomach Neoplasms
Loss of 15-hydroxyprostaglandin dehydrogenase expression contributes to bladder cancer progression.
Stomach Neoplasms
MicroRNA-21 induces loss of 15-hydroxyprostaglandin dehydrogenase in early gastric tubular adenocarcinoma.
Stomach Neoplasms
Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma.
Tendinopathy
Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy.
Thyroid Neoplasms
15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line.
Thyroid Neoplasms
Sequence of a novel mRNA coding for a C-terminal-truncated form of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.
Thyroid Neoplasms
Tumor growth inhibition by indomethacin in a mouse model of human medullary thyroid cancer: implication of cyclooxygenases and 15-hydroxyprostaglandin dehydrogenase.
Triple Negative Breast Neoplasms
Upregulation of Cyclooxygenase-2/Prostaglandin E2 (COX-2/PGE2) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer.
Ureteral Obstruction
Deficiency in 15-hydroxyprostaglandin dehydrogenase activity after unilateral ureteral obstruction of the dog kidney.
Ureteral Obstruction
Increase in enzyme activities of prostaglandin biosynthesis and catabolism by acute ureteral ligation in rat kidney.
Ureteral Obstruction
Suppression of 15-hydroxyprostaglandin dehydrogenase messenger RNA concentration, protein expression, and enzymatic activity during human ureteral obstruction.
Urinary Bladder Neoplasms
Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder.
Urinary Bladder Neoplasms
Loss of 15-hydroxyprostaglandin dehydrogenase expression contributes to bladder cancer progression.
Urinary Bladder Neoplasms
Search for the tumor-related proteins of transition cell carcinoma in Taiwan by proteomic analysis.
Uterine Cervical Neoplasms
Down-regulation of HPGD by miR-146b-3p promotes cervical cancer cell proliferation, migration and anchorage-independent growth through activation of STAT3 and AKT pathways.
Uterine Hemorrhage
Mifepristone-induced vaginal bleeding is associated with increased immunostaining for cyclooxygenase-2 and decrease in prostaglandin dehydrogenase in luteal phase endometrium.
Uterine Inertia
Investigations on the potential role of prostaglandin E2 in canine uterine inertia.
Virus Diseases
Oncolytic herpes simplex virus 1 encoding 15-prostaglandin dehydrogenase mitigates immune suppression and reduces ectopic primary and metastatic breast cancer in mice.
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0.000068
(1-butyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000022
(1-phenyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000034
(1-tert-butyl-1H-benzimidazol-5-yl)(piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000068
(3,3-dimethylpiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone
Homo sapiens
pH and temperature not specified in the publication
0.000271
(3,5-dimethylpiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone
Homo sapiens
pH and temperature not specified in the publication
0.000076
(4-bromopiperidin-1-yl)[1-(3-methylphenyl)-1H-benzimidazol-5-yl]methanone
Homo sapiens
pH and temperature not specified in the publication
0.000068
(piperidin-1-yl)[1-[3-(propan-2-yl)phenyl]-1H-benzimidazol-5-yl]methanone
Homo sapiens
pH and temperature not specified in the publication
0.000048
(piperidin-1-yl)[1-[3-(trifluoromethyl)phenyl]-1H-benzimidazol-5-yl]methanone
Homo sapiens
pH and temperature not specified in the publication
0.00086
(piperidin-1-yl)[1-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-5-yl]methanone
Homo sapiens
pH and temperature not specified in the publication
0.000242
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
Homo sapiens
pH and temperature not specified in the publication
0.000192
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
Homo sapiens
pH and temperature not specified in the publication
0.000383
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9,10,11-hexahydro-5H-[1,2,4]triazolo[4,3-a]azonine
Homo sapiens
pH and temperature not specified in the publication
0.000054
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.00304
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole
Homo sapiens
pH and temperature not specified in the publication
0.000022
3-[1-(3,4-dichlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000034
3-[1-(3-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000048
3-[1-(4-bromophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000038
3-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000121
3-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000086
3-[1-(4-methoxyphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000136
3-[1-(4-tert-butylphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000034
3-[2,5-dimethyl-1-(4-methylphenyl)-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000108
3-[2,5-dimethyl-1-(4-nitrophenyl)-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000048
3-[2,5-dimethyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000108
3-[2,5-dimethyl-1-[4-(naphthalen-2-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.001078
3-[2,5-dimethyl-1-[4-(pyridin-2-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000271
3-[2,5-dimethyl-1-[4-(pyridin-3-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000383
3-[2,5-dimethyl-1-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000068
3-[2,5-dimethyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
pH and temperature not specified in the publication
0.000076
3-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzonitrile
Homo sapiens
pH and temperature not specified in the publication
0.000264
4-((2,5-dioxopyrrolidin-3-ylidene)methyl)phenylthiophene-2-carboxylate
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000096
4-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzonitrile
Homo sapiens
pH and temperature not specified in the publication
0.008915
5-(2-chloro-3-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000211
5-(2-chloro-4-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.00105
5-(2-chloro-4-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000013
5-(2-chloro-4-(2-cyclohexylethoxy)benzylidene)-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000042
5-(2-chloro-4-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.00454
5-(2-chloro-4-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000081
5-(2-chloro-4-phenbutoxybenzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000178
5-(2-chloro-4-phenethoxybenzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000052
5-(2-chloro-4-phenpropoxybenzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000075
5-(3-chloro-4-((4-(prop-1-en-2-yl)cyclohexyl)methoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000071
5-(3-chloro-4-((5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.005165
5-(3-chloro-4-(2-(4-methyl-1,3-thiazolidin-5-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.002077
5-(3-chloro-4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000123
5-(3-chloro-4-(2-(5-nitrofuran-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.00002
5-(3-chloro-4-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.002738
5-(3-chloro-4-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.00444
5-(3-chloro-4-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000084
5-(3-chloro-4-(2-(thiophen-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000099
5-(3-chloro-4-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000132
5-(3-chloro-4-(2-cyclopropylpropyl)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000223
5-(3-chloro-4-(2-thiomorpholine 1,1-dioxideethoxy)benzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000059
5-(3-chloro-4-(3-(2-nitroethenyl)phenoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.0001
5-(3-chloro-4-(3-nitrophenoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000038
5-(3-chloro-4-(3-phenylpropoxy)benzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.00093
5-(3-chloro-4-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000048
5-(3-chloro-4-(4-phenylbutoxy)benzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000009
5-(3-chloro-4-(cyclobutylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000011
5-(3-chloro-4-(cyclopentylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.00002
5-(3-chloro-4-phenylethoxybenzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000193
5-(4-(1,3-benzodioxol-5-ylmethoxy)-3-chlorobenzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000487
5-(4-(benzyloxy)-2-chlorobenzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000048
5-(4-(benzyloxy)-3-chlorobenzylidene)thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000165
5-(4-(bicyclo[2.2.1]hept-2-ylmethoxy)-3-chlorobenzylidene)-1,3-thiazolidine-2,4-dione
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000051
CT-8
Homo sapiens
at pH 7.5, temperature not specified in the publication
0.000038
ethyl 4-[2,5-dimethyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-1H-pyrrol-1-yl]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.000383
N,N-diethyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.001358
N-butyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.000961
N-cyclopentyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.000027
[1-(2-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000012
[1-(3-chlorophenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000019
[1-(3-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000022
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](3-methylpiperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000429
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](3-phenylpiperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.00271
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](4-methylpiperazin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.00304
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](morpholin-4-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000019
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000383
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](pyrrolidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000048
[1-(3-methylphenyl)-1H-benzimidazol-5-yl][3-(propan-2-yl)piperidin-1-yl]methanone
Homo sapiens
pH and temperature not specified in the publication
0.000068
[1-(3-methylphenyl)-1H-benzimidazol-5-yl][3-(trifluoromethyl)piperidin-1-yl]methanone
Homo sapiens
pH and temperature not specified in the publication
0.001524
[1-(3-methylphenyl)-1H-benzimidazol-5-yl][4-(trifluoromethyl)piperidin-1-yl]methanone
Homo sapiens
pH and temperature not specified in the publication
0.000171
[1-(3-tert-butylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.00022
[1-(4-chlorophenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.00019
[1-(4-methoxyphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.00019
[1-(4-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000054
[1-(4-tert-butylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
Homo sapiens
pH and temperature not specified in the publication
0.000631
(4-([(4-chlorophenyl)sulfanyl]methyl)phenyl)(4-methylpiperidin-1-yl)methanone
Homo sapiens
-
pH 8, 25°C
0.000089
(4-[(2-bromophenoxy)methyl]phenyl)(piperidin-1-yl)methanone
Homo sapiens
-
pH 8, 25°C
0.000019
(5Z)-5-[3-bromo-4-(2-cyclohexylethoxy)benzylidene]-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000008
(5Z)-5-[3-chloro-4-(2-cyclohexylethoxy)benzylidene]-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.00001
(5Z)-5-[3-chloro-4-(3-cyclohexylpropoxy)benzylidene]-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000024
(5Z)-5-[3-chloro-4-(4-cyclohexylbutoxy)benzylidene]-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000028
(5Z)-5-[3-chloro-4-(cyclohexylmethoxy)benzylidene]-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000047
(5Z)-5-[3-chloro-4-(cyclohexyloxy)benzylidene]-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000025
(5Z)-5-[4-(2-cyclohexylethoxy)-3-methoxybenzylidene]-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.05
(5Z)-5-[4-(2-cyclohexylethoxy)-3-methoxybenzylidene]-3-methyl-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000051
(5Z)-5-[4-(2-cyclohexylethoxy)benzylidene]-1,3-thiazolidine-2,4-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000141
2-([(6-bromo-4H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]methyl)benzonitrile
Homo sapiens
-
pH 8, 25°C
0.00089
3-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
Homo sapiens
-
pH 8, 25°C
0.000052
5-(4-((4-methylcyclohexyl)methoxy)benzylidene) thiazolidine-2,4-dione
Homo sapiens
-
pH 7.5, temperature not specified in the publication
0.000031
5-(4-(2-(thiophen-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
Homo sapiens
-
pH 7.5, temperature not specified in the publication
0.00006
5-(4-(2-(thiophen-3-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
Homo sapiens
-
pH 7.5, temperature not specified in the publication
0.000116
5-(4-(2-cyclopentylethoxy)benzylidene)thiazolidine-2,4-dione
Homo sapiens
-
pH 7.5, temperature not specified in the publication
0.000124
5-(4-(4-(chloromethyl)benzyloxy)benzylidene) thiazolidine-2,4-dione
Homo sapiens
-
pH 7.5, temperature not specified in the publication
0.000045
5-(4-(cyclopentylmethoxy)benzylidene)thiazolidine-2,4-dione
Homo sapiens
-
pH 7.5, temperature not specified in the publication
0.000056
[1-(3-methylphenyl)-1H-benzimidazol-5-yl](piperidin-1-yl)methanone
Homo sapiens
-
pH 8, 25°C
0.01
[4-(4-methoxyphenyl)piperazin-1-yl](4-[(phenylsulfanyl)methyl]phenyl)methanone
Homo sapiens
-
value above, pH 8, 25°C
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Lee, S.C.; Levine, L.
Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types
J. Biol. Chem.
250
548-552
1975
Canis lupus familiaris, Gallus gallus, Homo sapiens, Platyrrhini, Sus scrofa
brenda
Tombach, B.; Kusseler, R.; Schlegel, W.
Purification of human placental prostaglandin 15-hydroxydehydrogenase
J. Chromatogr.
521
231-238
1990
Homo sapiens
brenda
Braithwaite, S.S.; Jabarak, J.
Studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Purification and partial characterization
J. Biol. Chem.
250
2315-2318
1975
Homo sapiens
brenda
Jabarak, J.; Braithwaite, S.S.
Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta
Arch. Biochem. Biophys.
177
245-254
1976
Homo sapiens
brenda
Jung, A.; Schlegel, W.; Jackisch, R.; Friedrich, E.J.; Wendel, A.; Ruckrich, M.F.
15-Hydroxyprostaglandin dehydrogenase from human placenta. 1. Isolation and characterization
Hoppe-Seyler's Z. Physiol. Chem.
356
787-798
1975
Homo sapiens
brenda
Ruckrich, M.F.; Wendel, A.; Schlegel, W.; Jackisch, R.; Jung, A.
15-Hydroxyprostaglandin dehydrogenase from human placenta, II. Steady state kinetics and influence of prostaglandin F2alpha analogues
Hoppe-Seyler's Z. Physiol. Chem.
356
799-809
1975
Homo sapiens
brenda
Krook, M.; Marekov, L.; Jrnvall, H.
Purification and structural characterization of placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family
Biochemistry
29
738-743
1990
Homo sapiens
brenda
Jabarak, J.
Isolation and properties of an NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from human placenta
Methods Enzymol.
86
126-130
1982
Homo sapiens
brenda
Schlegel, W.; Demers, L.M.; Hildebrandt-Stark, H.E.; Behrman, H.R.; Greep, R.O.
Partial purification of human placental 15-hydroxy-prostaglandin dehydrogenase: kinetic properties
Prostaglandins
5
417-433
1974
Homo sapiens
brenda
Xun, C.Q.; Ensor, C.M.; Tai, H.H.
Regulation of synthesis and activity of NAD+-dependent 15-hydroxy-prostaglandin dehydrogenase (15-PGDH) by dexamethasone and phorbol ester in human erythroleukemia (HEL) cells
Biochem. Biophys. Res. Commun.
177
1258-1265
1991
Homo sapiens
brenda
Jarabak, J.
Polycyclic aromatic hydrocarbon quinones may be either substrates for or irreversible inhibitors of the human placental NAD-linked 15-hydroxyprostaglandin dehydrogenase
Arch. Biochem. Biophys.
292
239-243
1992
Homo sapiens
brenda
Mibe, M.; Nagai, K.; Oshige, T.; Mori, N.
Endogenous inhibitors of human placental prostaglandin dehydrogenase
Prostaglandins Leukot. Essent. Fatty Acids
46
241-245
1992
Homo sapiens
brenda
Chavan, A.J.; Ensoe, C.M.; Wu, P.; Haley, B.E.; Tai, H.H.
Photoaffinity labeling of human placental NAD+-linked 15-hydroxyprostaglandin dehydrogenase with [alpha-32]2N3NAD+
J. Biol. Chem.
268
16437-16442
1993
Homo sapiens
brenda
Hhl, W.; Stahl, B.; Mundkowski, R.; Hofmann, U.; Meese, C.O.; Kuhlmann, U.; Schlegel, W.
Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z,8E,10E,12S)-12-hydroxy-5,8,10,-heptadecatrienoic acid as substrate
Eur. J. Biochem.
214
67-73
1993
Homo sapiens
brenda
Ensoe, C.M.; Tai, H.H.
Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
Biochim. Biophys. Acta
1208
151-156
1994
Homo sapiens
brenda
Okita, R.T.; Okita, J.R.
Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD+-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase
CRC Crit. Rev. Biochem.
31
101-126
1996
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus scrofa
brenda
Tong, M.; Tai, H.H.
Induction of NAD+-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells
Biochem. Biophys. Res. Commun.
276
77-81
2000
Homo sapiens
brenda
Tai, H.H.; Ensor, C.M.; Zhou, H.; Yan, F.
Structure and function of human NAD+-linked 15-hydroxyprostaglandin dehydrogenase
Adv. Exp. Med. Biol.
507
245-250
2002
Homo sapiens
brenda
Cho, H.; Tai, H.H.
Thiazolidinediones as a novel class of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
Arch. Biochem. Biophys.
405
247-251
2002
Homo sapiens
brenda
Cho, H.; Oliveira, M.A.; Tai, H.H.
Critical residues for the coenzyme specificity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
Arch. Biochem. Biophys.
419
139-146
2003
Homo sapiens
brenda
Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.
Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase
Arch. Biochem. Biophys.
433
447-453
2005
Homo sapiens
brenda
Tong, M.; Tai, H.H.
15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells
Arch. Biochem. Biophys.
435
50-55
2005
Homo sapiens
brenda
Cho, H.; Tai, H.H.
Threonine 11 of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase may interact with NAD(+) during catalysis
Prostaglandins
66
505-509
2002
Homo sapiens
brenda
Cho, H.; Tai, H.H.
Inhibition of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by cyclooxygenase inhibitors and chemopreventive agents
Prostaglandins
67
461-465
2002
Homo sapiens
brenda
Otani, T.; Yamaguchi, K.; Scherl, E.; Du, B.; Tai, H.H.; Greifer, M.; Petrovic, L.; Daikoku, T.; Dey, S.K.; Subbaramaiah, K.; Dannenberg, A.J.
Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha
Am. J. Physiol.
290
G361-G368
2006
Homo sapiens
brenda
Tong, M.; Ding, Y.; Tai, H.H.
Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells
Biochem. Pharmacol.
72
701-709
2006
Homo sapiens
brenda
Hamza, A.; Cho, H.; Tai, H.H.; Zhan, C.G.
Understanding human 15-hydroxyprostaglandin dehydrogenase binding with NAD+ and PGE2 by homology modeling, docking and molecular dynamics simulation
Bioorg. Med. Chem.
13
4544-4551
2005
Homo sapiens
brenda
Mann, J.R.; Backlund, M.G.; Buchanan, F.G.; Daikoku, T.; Holla, V.R.; Rosenberg, D.W.; Dey, S.K.; DuBois, R.N.
Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression
Cancer Res.
66
6649-6656
2006
Homo sapiens
brenda
Wolf, I.; OKelly, J.; Rubinek, T.; Tong, M.; Nguyen, A.; Lin, B.T.; Tai, H.H.; Karlan, B.Y.; Koeffler, H.P.
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer
Cancer Res.
66
7818-7823
2006
Homo sapiens
brenda
Ding, Y.; Tong, M.; Liu, S.; Moscow, J.A.; Tai, H.H.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer
Carcinogenesis
26
65-72
2005
Homo sapiens
brenda
Tong, M.; Ding, Y.; Tai, H.H.
Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells
Carcinogenesis
27
2170-2179
2006
Homo sapiens
brenda
Tai, H.H.; Cho, H.; Tong, M.; Ding, Y.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions
Curr. Pharm. Des.
12
955-962
2006
Homo sapiens
brenda
Backlund, M.G.; Mann, J.R.; Holla, V.R.; Buchanan, F.G.; Tai, H.H.; Musiek, E.S.; Milne, G.L.; Katkuri, S.; DuBois, R.N.
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer
J. Biol. Chem.
280
3217-3223
2005
Homo sapiens, Mus musculus
brenda
Quidville, V.; Segond, N.; Lausson, S.; Frenkian, M.; Cohen, R.; Jullienne, A.
15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line
Prostaglandins Other Lipid Mediat.
81
14-30
2006
Homo sapiens
brenda
Yang, L.; Amann, J.M.; Kikuchi, T.; Porta, R.; Guix, M.; Gonzalez, A.; Park, K.H.; Billheimer, D.; Arteaga, C.L.; Tai, H.H.; DuBois, R.; Carbone, D.P.; Johnson, D.H.
Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer
Cancer Res.
67
5587-5593
2007
Homo sapiens
brenda
Huang, G.; Eisenberg, R.; Yan, M.; Monti, S.; Lawrence, E.; Fu, P.; Walbroehl, J.; Loewenberg, E.; Golub, T.; Merchan, J.; Tenen, D.G.; Markowitz, S.D.; Halmos, B.
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer
Cancer Res.
68
5040-5048
2008
Homo sapiens
brenda
Michelet, J.F.; Colombe, L.; Gautier, B.; Gaillard, O.; Benech, F.; Pereira, R.; Boulle, C.; Dalko-Csiba, M.; Rozot, R.; Neuwels, M.; Bernard, B.A.
Expression of NAD(+) dependent 15-hydroxyprostaglandin dehydrogenase and protection of prostaglandins in human hair follicle
Exp. Dermatol.
17
821-828
2008
Homo sapiens (P15428), Homo sapiens
brenda
Hazra, S.; Batra, R.K.; Tai, H.H.; Sharma, S.; Cui, X.; Dubinett, S.M.
Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase
Mol. Pharmacol.
71
1715-1720
2007
Homo sapiens
brenda
Uppal, S.; Diggle, C.P.; Carr, I.M.; Fishwick, C.W.; Ahmed, M.; Ibrahim, G.H.; Helliwell, P.S.; Latos-Biele?ska, A.; Phillips, S.E.; Markham, A.F.; Bennett, C.P.; Bonthron, D.T.
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy
Nat. Genet.
40
789-793
2008
Homo sapiens
brenda
Tai, H.H.; Tong, M.; Ding, Y.
15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer
Prostaglandins Other Lipid Mediat.
83
203-208
2007
Homo sapiens
brenda
Rizek, R.M.; Watson, C.S.; Keating, S.; Tai, H.; Challis, J.R.; Bocking, A.D.
15-Hydroxyprostaglandin dehydrogenase protein expression in human fetal membranes with and without subclinical inflammation
Reprod. Sci.
14
260-269
2007
Homo sapiens
brenda
Miyaki, A.; Yang, P.; Tai, H.H.; Subbaramaiah, K.; Dannenberg, A.J.
Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes
Am. J. Physiol. Gastrointest. Liver Physiol.
297
G559-G566
2009
Homo sapiens
brenda
Chi, X.; Freeman, B.M.; Tong, M.; Zhao, Y.; Tai, H.H.
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells
Arch. Biochem. Biophys.
487
139-145
2009
Homo sapiens
brenda
Hughes, D.; Otani, T.; Yang, P.; Newman, R.A.; Yantiss, R.K.; Altorki, N.K.; Port, J.L.; Yan, M.; Markowitz, S.D.; Mazumdar, M.; Tai, H.H.; Subbaramaiah, K.; Dannenberg, A.J.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer
Cancer Prev. Res. (Phila.)
1
241-249
2008
Homo sapiens
brenda
Backlund, M.G.; Mann, J.R.; Holla, V.R.; Shi, Q.; Daikoku, T.; Dey, S.K.; DuBois, R.N.
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and Snail in colorectal cancer
Cancer Res.
68
9331-9337
2008
Homo sapiens
brenda
Tariq, M.; Azeem, Z.; Ali, G.; Chishti, M.S.; Ahmad, W.
Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC)
J. Med. Genet.
46
14-20
2009
Homo sapiens
brenda
Celis, J.E.; Gromov, P.; Cabezon, T.; Moreira, J.M.; Friis, E.; Jirstroem, K.; Llombart-Bosch, A.; Timmermans-Wielenga, V.; Rank, F.; Gromova, I.
15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma
Mol. Cell. Proteomics
7
1795-1809
2008
Homo sapiens (P15428)
brenda
Wei, C.; Zhu, P.; Shah, S.J.; Blair, I.A.
15-oxo-Eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation
Mol. Pharmacol.
76
516-525
2009
Homo sapiens
brenda
Wu, Y.; Tai, H.H.; Cho, H.
Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors
Bioorg. Med. Chem.
18
1428-1433
2010
Homo sapiens
brenda
Liu, Z.; Wang, X.; Lu, Y.; Du, R.; Luo, G.; Wang, J.; Zhai, H.; Zhang, F.; Wen, Q.; Wu, K.; Fan, D.
15-Hydroxyprostaglandin dehydrogenase is a tumor suppressor of human gastric cancer
Cancer Biol. Ther.
10
780-787
2010
Homo sapiens
brenda
Chi, X.; Tai, H.H.
Interleukin-4 up-regulates 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human lung cancer cells
Exp. Cell Res.
316
2251-2259
2010
Homo sapiens
brenda
Wu, Y.; Karna, S.; Choi, C.H.; Tong, M.; Tai, H.H.; Na, D.H.; Jang, C.H.; Cho, H.
Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors
J. Med. Chem.
54
5260-5264
2011
Homo sapiens
brenda
Thill, M.; Fischer, D.; Kelling, K.; Hoellen, F.; Dittmer, C.; Hornemann, A.; Salehin, D.; Diedrich, K.; Friedrich, M.; Becker, S.
Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH2)D3) and prostaglandin E2 (PGE2) serum level in ovarian cancer
J. Steroid Biochem. Mol. Biol.
121
387-390
2010
Homo sapiens
brenda
Lu, D.; Han, C.; Wu, T.
15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARgamma-mediated activation of p21(WAF1/Cip1.)
Oncogene
33
1101-1112
2013
Homo sapiens
brenda
Niesen, F.; Schultz, L.; Jadhav, A.; Bhatia, C.; Guo, K.; Maloney, D.; Pilka, E.; Wang, M.; Oppermann, U.; Heightman, T.; Simeonov, A.
High-affinity inhibitors of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships
PLoS ONE
5
e13719
2010
Homo sapiens
brenda
Duveau, D.Y.; Yasgar, A.; Wang, Y.; Hu, X.; Kouznetsova, J.; Brimacombe, K.R.; Jadhav, A.; Simeonov, A.; Thomas, C.J.; Maloney, D.J.
Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
Bioorg. Med. Chem. Lett.
24
630-635
2014
Homo sapiens (P15428), Homo sapiens
brenda
Choi, D.; Piao, Y.L.; Wu, Y.; Cho, H.
Control of the intracellular levels of prostaglandin E2 through inhibition of the 15-hydroxyprostaglandin dehydrogenase for wound healing
Bioorg. Med. Chem.
21
4477-4484
2013
Homo sapiens (P15428)
brenda
Castro-Sanchez, L.; Agra, N.; Llorente Izquierdo, C.; Motino, O.; Casado, M.; Bosca, L.; Martin-Sanz, P.
Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma
Int. J. Biochem. Cell Biol.
45
2501-2511
2013
Homo sapiens (P15428), Homo sapiens
brenda
Lu, D.; Han, C.; Wu, T.
15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-gamma, SMAD2/3, and TAP63 proteins
J. Biol. Chem.
288
19484-19502
2013
Homo sapiens (P15428), Homo sapiens
brenda
Kim, H.J.; Lee, S.; Lee, H.Y.; Won, H.; Chang, S.H.; Nah, S.S.
15-hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes
Mol. Med. Rep.
12
4141-4148
2015
Homo sapiens (P15428), Homo sapiens
brenda
Kim, H.; Lee, H.; Lim, K.; Surh, Y.; Na, H.
15-Deoxy-DELTA12,14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 cells
Mutat. Res.
768
6-15
2014
Homo sapiens (P15428), Homo sapiens
brenda
Sola-Villa, D.; Dilme, J.F.; Rodriguez, C.; Soto, B.; Vila, L.; Escudero, J.R.; Martinez-Gonzalez, J.; Camacho, M.
Expression and cellular localization of 15-hydroxy-prostaglandin-dehydrogenase in abdominal aortic aneurysm
PLoS ONE
10
e0136201
2015
Homo sapiens (P15428), Homo sapiens
brenda
Lee, J.; Zhong, X.; Lee, J.; Surh, Y.; Na, H.
15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells
Arch. Biochem. Biophys.
679
108162
2020
Homo sapiens (P15428), Homo sapiens
brenda