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2-deoxy-D-ribose + NAD+
? + NADH
-
10% of the activity compared to L-fucose or D-arabinose
-
?
3-amino-3-deoxy-D-arabinose + NAD+
3-amino-3-deoxy-D-arabino-1,5-lactone + NADH
-
15% of the activity compared to L-fucose
-
?
3-amino-3-deoxy-D-arabinose + NAD+
3-amino-3-deoxy-D-arabino-1,5-lactone + NADH + H+
-
-
-
-
r
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
D-arabinose + NADP+
D-arabinolactone + NADPH + H+
D-galactose + NAD+
D-galactono-1,5-lactone + NADH + H+
D-lyxose + NAD+
? + NADH
-
4% of the activity compared to L-fucose
-
?
D-ribose + NAD+
? + NADH
-
8% of the activity compared to D-arabinose or L-xylose
-
?
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
fuconolactone + NADPH + H+
L-fucose + NADP+
L-fucose + NAD+
L-fuconolactone + NADH + H+
L-fucose + NADP+
L-fuconolactone + NADPH + H+
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
L-galactose + NADP+
?
-
L-galactose is a poor substrate with 11% activity compared to L-fucose
-
-
?
L-glucose + NAD+
L-glucono-1,5-lactone + NADH
-
68% of the activity compared to D-arabinose or L-xylose
-
?
L-xylose + NAD+
L-xylono-1,5-lactone + NADH
additional information
?
-
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
irreversible because of spontaneous conversion to L-fuconic acid during incubation
-
ir
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
ir
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
ordered bi-bi-reaction mechanism
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose
-
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose. The enzyme is specific for sugars with D-arabinose-type hydroxyl group stereo-configurations at C3 and C4. This configuration is shared among the hexoses L-fucose (6-deoxy-L-galactose) and L-galactose, and the pentose D-ribose. Although the highest activity is observed with L-fucose in combination with NAD+, the remaining sugars are oxidized at higher rates using NADP+
-
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose. The enzyme is specific for sugars with D-arabinose-type hydroxyl group stereo-configurations at C3 and C4. This configuration is shared among the hexoses L-fucose (6-deoxy-L-galactose) and L-galactose, and the pentose D-ribose. Although the highest activity is observed with L-fucose in combination with NAD+, the remaining sugars are oxidized at higher rates using NADP+
-
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose
-
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
73% of the activity compared to D-arabinose or L-xylose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
71% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
74.5% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
74.5% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
-
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
84% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
-
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
66% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
100% activity
-
?
D-arabinose + NADP+
D-arabinolactone + NADPH + H+
-
good substrate with 65% activity compared to L-fucose
-
-
?
D-arabinose + NADP+
D-arabinolactone + NADPH + H+
-
good substrate with 65% activity compared to L-fucose
-
-
?
D-galactose + NAD+
D-galactono-1,5-lactone + NADH + H+
-
-
-
-
r
D-galactose + NAD+
D-galactono-1,5-lactone + NADH + H+
-
-
-
-
r
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
-
2.1% of the activity compared to L-fucose
-
?
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
-
9% of the activity compared to D-arabinose or L-xylose
-
?
fuconolactone + NADPH + H+
L-fucose + NADP+
-
-
-
-
?
fuconolactone + NADPH + H+
L-fucose + NADP+
-
-
-
-
?
fuconolactone + NADPH + H+
L-fucose + NADP+
-
-
-
-
?
fuconolactone + NADPH + H+
L-fucose + NADP+
-
-
-
-
?
L-fucose + NAD+
L-fuconolactone + NADH + H+
-
-
-
-
?
L-fucose + NAD+
L-fuconolactone + NADH + H+
-
-
-
-
?
L-fucose + NADP+
L-fuconolactone + NADPH + H+
-
good substrate
-
-
?
L-fucose + NADP+
L-fuconolactone + NADPH + H+
-
100% activity
-
-
?
L-fucose + NADP+
L-fuconolactone + NADPH + H+
-
good substrate
-
-
?
L-fucose + NADP+
L-fuconolactone + NADPH + H+
-
100% activity
-
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
57% of the activity compared to L-fucose
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
59.6% of the activity compared to L-fucose
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
59.6% of the activity compared to L-fucose
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
-
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
-
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
13% of the activity compared to L-fucose
-
?
L-xylose + NAD+
L-xylono-1,5-lactone + NADH
-
4% of the activity compared to L-fucose
-
?
L-xylose + NAD+
L-xylono-1,5-lactone + NADH
-
100% activity
-
?
additional information
?
-
-
no activity with D-glucose, D-fructose, D-galactose, L-arabinose, D-mannose, L-rhamnose, D-xylose, maltose, sucrose, and lactose
-
-
?
additional information
?
-
-
no activity with D-glucose, D-fructose, D-galactose, L-arabinose, D-mannose, L-rhamnose, D-xylose, maltose, sucrose, and lactose
-
-
?
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2-deoxy-D-ribose + NAD+
? + NADH
-
10% of the activity compared to L-fucose or D-arabinose
-
?
3-amino-3-deoxy-D-arabinose + NAD+
3-amino-3-deoxy-D-arabino-1,5-lactone + NADH
-
15% of the activity compared to L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
D-lyxose + NAD+
? + NADH
-
4% of the activity compared to L-fucose
-
?
D-ribose + NAD+
? + NADH
-
8% of the activity compared to D-arabinose or L-xylose
-
?
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
L-fucose + NADP+
L-fuconolactone + NADPH + H+
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
L-glucose + NAD+
L-glucono-1,5-lactone + NADH
-
68% of the activity compared to D-arabinose or L-xylose
-
?
L-xylose + NAD+
L-xylono-1,5-lactone + NADH
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
irreversible because of spontaneous conversion to L-fuconic acid during incubation
-
ir
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
ir
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
ordered bi-bi-reaction mechanism
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
73% of the activity compared to D-arabinose or L-xylose
-
?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
-
i.e. L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
71% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
74.5% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
74.5% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
-
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
84% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
-
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
66% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
-
100% activity
-
?
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
-
2.1% of the activity compared to L-fucose
-
?
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
-
9% of the activity compared to D-arabinose or L-xylose
-
?
L-fucose + NADP+
L-fuconolactone + NADPH + H+
-
100% activity
-
-
?
L-fucose + NADP+
L-fuconolactone + NADPH + H+
-
100% activity
-
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
57% of the activity compared to L-fucose
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
59.6% of the activity compared to L-fucose
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
59.6% of the activity compared to L-fucose
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
-
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
-
-
?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
-
13% of the activity compared to L-fucose
-
?
L-xylose + NAD+
L-xylono-1,5-lactone + NADH
-
4% of the activity compared to L-fucose
-
?
L-xylose + NAD+
L-xylono-1,5-lactone + NADH
-
100% activity
-
?
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Itoh, H.; Miyoshi, T.; Yoshino, A.; Shiragami, K.; Izumori, K.
Purification and characterization of L-fucose dehydrogenase from Agrobacterium tumefaciens K-28
J. Ferment. Bioeng.
77
100-102
1994
Agrobacterium tumefaciens, Agrobacterium tumefaciens K-28
-
brenda
Yamamoto-Otake, H.; Nakano, E.; Koyama, Y.
Cloning and sequencing of the L-fucose dehydrogenase gene from Pseudomonas sp. no. 1143
Biosci. Biotechnol. Biochem.
58
2281-2282
1994
Pseudomonas sp.
brenda
Tsuji, Y.; Koike, A.; Yamamoto, K.; Tochikura, T.
Purification and some properties of L-fucose dehydrogenase from Agrobacterium radiobacter and its application to the assay of bound-fucose in glycoconjugates
Biochim. Biophys. Acta
1117
167-173
1992
Agrobacterium tumefaciens
brenda
Guimaraes, M.F.; Veiga, L.A.
Purification and general properties of L-fucose dehydrogenase from Pullularia pullulans
Arq. Biol. Tecnol. (Curitiba)
32
575-587
1989
Aureobasidium pullulans
-
brenda
Sasajima, K.I.; Sinskey, A.J.
Oxidation of L-glucose by a pseudomonad
Biochim. Biophys. Acta
571
120-126
1979
Trinickia caryophylli
brenda
Mobley, P.W.; Metzger, R.P.
The physical properties of NAD-dependent L-fucose dehydrogenase from sheep liver
Arch. Biochem. Biophys.
186
184-188
1978
Ovis aries aries
brenda
Mobley, P.W.; Metzger, R.P.; Wick, A.N.
L-Fucose dehydrogenase from sheep liver
Methods Enzymol.
41B
173-177
1975
Ovis aries aries
brenda
Endo, M.; Hiyama, N.
Isolation and characterization of L-fucose dehydrogenase from rabbit liver
J. Biochem.
86
1559-1565
1979
Oryctolagus cuniculus
brenda
Schacter, H.; Sarney, J.; McGuire, E.J.; Roseman, S.
Isolation of diphosphopyridine nucleotide-dependent L-fucose dehydrogenase from pork liver
J. Biol. Chem.
244
4785-4792
1969
Sus scrofa
brenda
Bakke, M.; Furukawa, K.; Kajiyama, N.
Improvement in thermal stability of L-fucose dehydrogenase by chemical modification and additives for use as an NADPH recycling reagent
Biotechnol. Lett.
24
1075-1078
2002
Pseudomonas sp., Pseudomonas sp. No. 1143
-
brenda
Brouns, S.J.; Turnbull, A.P.; Willemen, H.L.; Akerboom, J.; van der Oost, J.
Crystal structure and biochemical properties of the D-arabinose dehydrogenase from Sulfolobus solfataricus
J. Mol. Biol.
371
1249-1260
2007
Saccharolobus solfataricus (Q97YM2), Saccharolobus solfataricus P2 (Q97YM2)
brenda
Brouns, S.J.; Walther, J.; Snijders, A.P.; van de Werken, H.J.; Willemen, H.L.; Worm, P.; de Vos, M.G.; Andersson, A.; Lundgren, M.; Mazon, H.F.; van den Heuvel, R.H.; Nilsson, P.; Salmon, L.; de Vos, W.M.; Wright, P.C.; Bernander, R.; van der Oost, J.
Identification of the missing links in prokaryotic pentose oxidation pathways: evidence for enzyme recruitment
J. Biol. Chem.
281
27378-27388
2006
Saccharolobus solfataricus (Q97YM2), Saccharolobus solfataricus P2 (Q97YM2)
brenda
Ohshiro, T.; Morita, N.
Production and characterization of L-fucose dehydrogenase from newly isolated Acinetobacter sp. strain SA-134
Prep. Biochem. Biotechnol.
44
382-391
2014
Acinetobacter sp., Acinetobacter sp. SA-134
brenda
Seydametova, E.; Shin, J.; Yu, S.H.; Kim, C.; Kim, H.; Park, Y.J.; Yang, J.K.; Cho, S.; Kim, H.R.; Moon, S.O.; Ban, C.; Kweon, D.H.
Development of a quantitative assay for 2'-fucosyllactose via one-pot reaction with alpha1,2-fucosidase and L-fucose dehydrogenase
Anal. Biochem.
582
113358
2019
Pseudomonas sp. (Q52472), Pseudomonas sp., Pseudomonas sp. 1143 (Q52472)
brenda