Information on EC 1.1.1.113 - L-xylose 1-dehydrogenase

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The expected taxonomic range for this enzyme is: Archaea, Eukaryota

EC NUMBER
COMMENTARY hide
1.1.1.113
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RECOMMENDED NAME
GeneOntology No.
L-xylose 1-dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-xylose + NADP+ = L-xylono-1,4-lactone + NADPH + H+
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
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redox reaction
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-
-
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reduction
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-
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SYSTEMATIC NAME
IUBMB Comments
L-xylose:NADP+ 1-oxidoreductase
Also oxidizes D-arabinose and D-lyxose.
CAS REGISTRY NUMBER
COMMENTARY hide
37250-44-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-arabinose + NADP+
D-arabinono-1,4-lactone + NADPH
show the reaction diagram
-
-
-
?
D-lyxose + NADP+
D-lyxono-1,4-lactone + NADPH
show the reaction diagram
-
-
-
?
D-xylose + NADP+
?
show the reaction diagram
L-xylose + NADP+
L-xylono-1,4-lactone + NADPH
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-xylose + NADP+
L-xylono-1,4-lactone + NADPH
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
89000
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
65
half-life: 56.8 h, in the presence of 3 M NaCl, stability decreases significantly with lower salt concentrations
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, stable for several months
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate, acetone, DEAE-cellulose
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K270D/N272P/S271G/R276F
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mutant shows a decreased NADPH and NADH xylose reductase activities, respectively, compared to wild-type
K270G
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mutant shows a decreased NADPH and NADH xylose reductase activities, respectively, compared to wild-type
K270M
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mutant shows a decreased NADPH and NADH xylose reductase activities, respectively, compared to wild-type
K270R
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mutant shows a 3.4fold and 2.4fold higher NADPH and NADH preferred xylose reductase activities, respectively, compared with wild-type. Mutant exhibits an improved xylose consumption rate, balanced redox system and increased ethanol yield and production rate
K270R/N272D
-
mutant shows a decreased NADPH and NADH xylose reductase activities, respectively, compared to wild-type
K270R/R276H
-
mutant shows a decreased NADPH and NADH xylose reductase activities, respectively, compared to wild-type
K274R
-
mutant shows a decreased NADPH and NADH xylose reductase activities, respectively, compared to wild-type
K274R/N276D
-
mutant shows a decreased NADPH and NADH xylose reductase activities, respectively, compared to wild-type