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Information on EC 1.1.1.102 - 3-dehydrosphinganine reductase and Organism(s) Mus musculus and UniProt Accession Q6GV12

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This record set is specific for:
Mus musculus
UNIPROT: Q6GV12 not found.
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
tsc10, tsc10p, 3-ketosphinganine reductase, 3-ketodihydrosphingosine reductase, fvt-1, kds reductase, 3-kds reductase, tsc10a, 3-dehydrosphinganine reductase, ksr1p, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-ketodihydrosphingosine reductase
-
KDS reductase
-
3-oxosphinganine reductase
-
-
-
-
3-oxosphinganine:NADPH oxidoreductase
-
-
-
-
D-3-dehydrosphinganine reductase
-
-
-
-
D-3-oxosphinganine reductase
-
-
-
-
D-3-oxosphinganine:B-NADPH oxidoreductase
-
-
-
-
DSR
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37250-36-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-ketodihydrosphingosine + NADPH
dihydrosphingosine + NADP+
show the reaction diagram
-
-
-
?
(S)-2-amino-1-hydroxyoctadecan-3-one + NADPH
(S)-2-amino-1-(R)-3-dihydroxyoctadecane + NADP+
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(S)-2-amino-1-hydroxyoctadecan-3-one + NADPH
(S)-2-amino-1-(R)-3-dihydroxyoctadecane + NADP+
show the reaction diagram
-
enzyme acts at the cytoplasmic side of endoplasmic reticulum
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000121
-
vesicles from smooth and rough endoplasmic reticulum
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
low level of expression
Manually annotated by BRENDA team
high expression
Manually annotated by BRENDA team
high expression
Manually annotated by BRENDA team
highest expression
Manually annotated by BRENDA team
low level of expression
Manually annotated by BRENDA team
high expression
Manually annotated by BRENDA team
low level of expression
Manually annotated by BRENDA team
high expression
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
of endoplasmic reticulum
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KDSR_MOUSE
332
1
35956
Swiss-Prot
Secretory Pathway (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in yeast cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mandon, E.C.; Ehses, I.; Rother, J.; van Echten, G.; Sandhoff, K.
Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver
J. Biol. Chem.
267
11144-11148
1992
Mus musculus
Manually annotated by BRENDA team
Kihara, A.; Igarashi, Y.
FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane
J. Biol. Chem.
279
49243-49250
2004
Homo sapiens (Q06136), Homo sapiens, Mus musculus (Q6GV12), Mus musculus
Manually annotated by BRENDA team