6.6.1.2: cobaltochelatase

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For detailed information about cobaltochelatase, go to the full flat file.

Reaction

Synonyms

CbiK, CbiXL, cobalt chelatase, cobaltochelatase, CobN-CobST, CobNST, CobN�CobST, gene cobN/gene cobS cobaltochelatase, holocobalamin synthase, hydrogenobyrinic acid a,c-diamide cobaltochelatase

ECTree

     6 Ligases

         6.6 Forming nitrogen—metal bonds

             6.6.1 Forming coordination complexes

                6.6.1.2 cobaltochelatase

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Results	in table
8639	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
3	Cofactor
2	Crystallization (Commentary)
2	Expression
10	Inhibitors
3	KM Value [mM]
2	Localization
1	Metals/Ions
4	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
9	Organism
5	Pathway
1	PDB ID
3	Purification (Commentary)
1	Reaction
7	Reference
1	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
3	Subunits
17	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 6.6.1.2 - cobaltochelatase

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SYSTEMATIC NAME

IUBMB Comments

hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)

This enzyme, which forms part of the aerobic (late cobalt insertion) cobalamin biosynthesis pathway, is a type I chelatase, being heterotrimeric and ATP-dependent. It comprises two components, one of which corresponds to CobN and the other is composed of two polypeptides, specified by cobS and cobT in Pseudomonas denitrificans, and named CobST [1]. Hydrogenobyrinate is a very poor substrate. ATP can be replaced by dATP or CTP but the reaction proceeds more slowly. CobN exhibits a high affinity for hydrogenobyrinate a,c-diamide. The oligomeric protein CobST possesses at least one sulfhydryl group that is essential for ATP-binding. See EC 4.99.1.3, sirohydrochlorin cobaltochelatase, for the cobaltochelatase that participates in the anaerobic cobalamin biosynthesis pathway.