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6.5.1.B3: 2'-5' RNA ligase (GTP-activated)

This is an abbreviated version!
For detailed information about 2'-5' RNA ligase (GTP-activated), go to the full flat file.

Word Map on EC 6.5.1.B3

Reaction

a 3'-half-tRNA molecule with a 5'-OH end
+
a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end
=
a mature tRNA molecule containing a 2'-5'-phosphodiester bond

Synonyms

GTP-dependent RNA ligase, PF0027, PH0099

ECTree

     6 Ligases
         6.5 Forming phosphoric-ester bonds
             6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
                6.5.1.B3 2'-5' RNA ligase (GTP-activated)

Reference

Reference on EC 6.5.1.B3 - 2'-5' RNA ligase (GTP-activated)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gao, Y.G.; Yao, M.; Okada, A.; Tanaka, I.
The structure of Pyrococcus horikoshii 2'-5' RNA ligase at 1.94 A resolution reveals a possible open form with a wider active-site cleft
Acta Crystallogr. Sect. F
62
1196-1200
2006
Pyrococcus horikoshii (O57823), Pyrococcus horikoshii, Pyrococcus horikoshii OT-3 (O57823)
Manually annotated by BRENDA team
Kanai, A.; Sato, A.; Fukuda, Y.; Okada, K.; Matsuda, T.; Sakamoto, T.; Muto, Y.; Yokoyama, S.; Kawai, G.; Tomita, M.
Characterization of a heat-stable enzyme possessing GTP-dependent RNA ligase activity from a hyperthermophilic archaeon, Pyrococcus furiosus
RNA
15
420-431
2009
Pyrococcus furiosus (Q8U4Q3), Pyrococcus furiosus
Manually annotated by BRENDA team