6.5.1.8: 3'-phosphate/5'-hydroxy nucleic acid ligase
This is an abbreviated version!
For detailed information about 3'-phosphate/5'-hydroxy nucleic acid ligase, go to the full flat file.
Reaction
Synonyms
3'-P RNL, MXAN_0280, MXAN_4982, RNA-splicing ligase, rtcB, RtcB RNA ligase, Rtcb-1, RtcB1, Trl1, tRNA splicing ligase, tRNA-splicing ligase
ECTree
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Metals Ions
Metals Ions on EC 6.5.1.8 - 3'-phosphate/5'-hydroxy nucleic acid ligase
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Mg2+
Mn2+
Zn2+
additional information
Mn2+
prior to binding GTP, a single manganese ion is bound to RtcB
Mn2+
the RtcB/Mn2+ structure shows two Mn2+ ions at the active site. The enzyme's substrate-induced GTP binding site and the putative reactive RNA ends are in the vicinity of the binuclear Mn2+ active center