6.5.1.4: RNA 3'-terminal-phosphate cyclase (ATP)

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For detailed information about RNA 3'-terminal-phosphate cyclase (ATP), go to the full flat file.

Reaction

Synonyms

PH1529, Rcl1p, RNA 3'-phosphate cyclase, RNA 3'-teminal phosphate cyclase, RNA 3'-terminal phosphate cyclase, RNA 3'-terminal phosphate cylase, RNA cyclase, RNA-3'-phosphate cyclase, RNL, Rtc, Rtc1, RtcA, St-Rtc

ECTree

     6 Ligases

         6.5 Forming phosphoric-ester bonds

             6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

                6.5.1.4 RNA 3'-terminal-phosphate cyclase (ATP)

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Systematic Name

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Systematic Name on EC 6.5.1.4 - RNA 3'-terminal-phosphate cyclase (ATP)

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SYSTEMATIC NAME

IUBMB Comments

RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)

The enzyme converts the 3'-terminal phosphate of various RNA substrates into the 2',3'-cyclic phosphodiester in an ATP-dependent reaction. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a histidine residue [5,6]. The adenylate group is then transferred to the 3'-phosphate terminus of the substrate, forming the capped structure [RNA]-3'-(5'-diphosphoadenosine). Finally, the enzyme catalyses an attack of the vicinal O-2' on the 3'-phosphorus, which results in formation of cyclic phosphate and release of the adenylate. The enzyme also has a polynucleotide 5' adenylylation activity [7]. cf. EC 6.5.1.5, RNA 3'-terminal-phosphate cyclase (GTP).