6.4.1.6: acetone carboxylase

This is an abbreviated version!
For detailed information about acetone carboxylase, go to the full flat file.

Word Map on EC 6.4.1.6

6.4.1.6

acetoacetate

xanthobacter

rhodobacter

capsulatus

carboxylases

autotrophicus

denitrify

butanone

acetophenone

acetone-grown

alpha2beta2gamma2

isopropanol

phototrophic

heterohexameric

alicycliphilus

rhodomicrobium

aromatoleum

thiolysis

ethylbenzene

vannielii

benzoylacetate

thiosphaera

nitrate-dependent

nitrate-reducing

pantotropha

aromaticum

acetoacetyl-coa

alkenes

metallidurans

cupriavidus

medicine

Reaction

+ 2 H2O =

+ 2 phosphate

Synonyms

acetone carboxylase, acetone-carboxylating enzyme, ACX, AcxA, AcxB, AcxC, Alide_1502, Alide_1503, Alide_1504, carboxylase, acetone

ECTree

6 Ligases

6.4 Forming carbon-carbon bonds

6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

6.4.1.6 acetone carboxylase

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Results	in table
4	Activating Compound
653	AA Sequence
1	Application
1	CAS Registry Number
8	Cofactor
1	Crystallization (Commentary)
3	Expression
2	General Information
1	General Stability
4	Inhibitors
7	KM Value [mM]
23	Metals/Ions
30	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
28	Organism
1	Oxidation Stability
3	Pathway
24	PDB ID
4	pH Optimum
1	pH Range
1	Protein Variants
8	Purification (Commentary)
4	Reaction
1	Reaction Type
22	Reference
2	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
37	Substrates and Products (Substrate)
8	Subunits
13	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.4.1.6 - acetone carboxylase

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acetone:carbon-dioxide ligase (AMP-forming)

Requires Mg2+ and ATP. The reaction involves separate phosphorylation of hydrogencarbonate and acetone, forming carboxyphosphate and phosphoenolacetone, respectively, which are combined to form the final product. The enzyme from Xanthobacter sp. strain Py2 also carboxylates butan-2-one to 3-oxopentanoate.