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6.4.1.4: methylcrotonoyl-CoA carboxylase

This is an abbreviated version!
For detailed information about methylcrotonoyl-CoA carboxylase, go to the full flat file.

Word Map on EC 6.4.1.4

Reaction

ATP
+
3-methylcrotonoyl-CoA
+
HCO3-
+
H+
=
ADP
+
phosphate
+
3-methylglutaconyl-CoA

Synonyms

3-MCC, 3-methylcrotonyl CoA carboxylase, 3-methylcrotonyl coenzyme A carboxylase, 3-methylcrotonyl coenzyme-A carboxylase, 3-methylcrotonyl-CoA carboxylase, 3-methylcrotonyl-CoA:carbon-dioxide ligase (ADP-forming), 3-methylcrotonyl-coenzyme A, 3-methylcrotonyl-coenzyme A carboxylase, beta-MCC, beta-methylcrotonyl CoA carboxylase, beta-Methylcrotonyl coenzyme A carboxylase, beta-methylcrotonyl-CoA carboxylase, Carboxylase, methylcrotonyl coenzyme A, glutaconyl-CoA decarboxylase, glutaconyl-CoA:biotin carboxytransferase, liuB, liuD, MC-CoA carboxylase, Mcase, MCC, Mcc2, MCCA, MCCase, MCCB, MCCC, Methylcrotonyl coenzyme A carboxylase, methylcrotonyl-CoA carboxylase, Pa-MCCase, PaMCC

ECTree

     6 Ligases
         6.4 Forming carbon-carbon bonds
             6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
                6.4.1.4 methylcrotonoyl-CoA carboxylase

Subunits

Subunits on EC 6.4.1.4 - methylcrotonoyl-CoA carboxylase

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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
dodecamer
heterodimer
heteromer
heterotetramer
co-expressed subunits form an (alpha-beta)4 complex that suffer a modification of its oligomerization
homodimer
-
alphabeta
multimer
-
x * 60000 + 6 * 80000, 3-methylcrotonyl-CoA carboxylase is a heteromultimeric complex (MW: 500000 Da-800000 Da) that is composed of alpha and beta subunits (ratio 1:1) which are encoded by distinct genes. MCCCalpha is the larger subunit that has 725 amino acids, which contains the Met-Lys-Met biotin attachment domain near its COOH end. Human MCCCbeta is the small subunit that is composed of 563 amino acids, which functions as a carboxyltransferase, SDS-PAGE
octamer
polymer
x * 85000 + x * 60000, heteromeric enzyme composed of biotin-containing MCC-A and non-biotin-containing MCC-B subunits
tetramer
-
1 * 65000 + 1 * 36000 + 1 * 25000 + 1 * 14000, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, SDS-PAGE, 1 * 64300 + 1 * 38902 + 1 * 14133 + 1 * 11624, alpha GcdA, beta GcdB, gamma GcdC, delta GcdD, amino acid sequence
additional information
heteromeric enzyme composed of 2 kinds of subunits, biotinylated MCC-A and non-, biotinylated MCC-B