6.4.1.1: pyruvate carboxylase
This is an abbreviated version!
For detailed information about pyruvate carboxylase, go to the full flat file.
Word Map on EC 6.4.1.1
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6.4.1.1
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phosphoenolpyruvate
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gluconeogenesis
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carboxykinase
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biotin
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oxaloacetate
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acetyl-coa
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tricarboxylic
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gluconeogenic
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anaplerotic
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malate
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citrate
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tca
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co2
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malic
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pepck
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carboxylases
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astrocyte
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glucose-6-phosphatase
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biotin-dependent
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acidosis
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propionyl-coa
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citric
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krebs
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glutamicum
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bark
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pine
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biotin-containing
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13c-labeled
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propionyl
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isotopomer
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maritime
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1-13cglucose
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avidin
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hyperammonemia
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fructose-1,6-diphosphatase
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carboxyltransferase
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pyrogenic
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4.1.1.32
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1,6-bisphosphatase
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holocarboxylase
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transcarboxylase
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biotinidase
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pyrolytic
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leigh
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ureagenesis
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medicine
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glucogenic
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biotechnology
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penicillinase
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13c-enriched
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pinaster
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synthesis
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3-methylcrotonyl-coa
- 6.4.1.1
- phosphoenolpyruvate
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gluconeogenesis
-
carboxykinase
- biotin
- oxaloacetate
- acetyl-coa
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tricarboxylic
-
gluconeogenic
-
anaplerotic
- malate
- citrate
- tca
- co2
-
malic
- pepck
- carboxylases
- astrocyte
- glucose-6-phosphatase
-
biotin-dependent
- acidosis
- propionyl-coa
-
citric
-
krebs
- glutamicum
-
bark
- pine
-
biotin-containing
-
13c-labeled
-
propionyl
-
isotopomer
-
maritime
-
1-13cglucose
- avidin
- hyperammonemia
-
fructose-1,6-diphosphatase
- carboxyltransferase
-
pyrogenic
-
4.1.1.32
-
1,6-bisphosphatase
- holocarboxylase
- transcarboxylase
- biotinidase
-
pyrolytic
- leigh
-
ureagenesis
- medicine
-
glucogenic
- biotechnology
- penicillinase
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13c-enriched
- pinaster
- synthesis
- 3-methylcrotonyl-coa
Reaction
Synonyms
Carboxylase, pyruvate, EhPYC1, HpPyc1p, Mfla_1512, MSmeg_2412, PC, Pcase, PCB, PCC, PCx, PYC, Pyc1, Pyc1p, PYC2, pycA, pyruvate carboxylase, pyruvate carboxylase 1, Pyruvic carboxylase, RePC
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General Information
General Information on EC 6.4.1.1 - pyruvate carboxylase
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malfunction
metabolism
physiological function
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a pycA insertion mutant defective in pyruvate carboxylase still grows, albeit at a reduced rate, in brain heart infusion medium but is unable to multiply in a defined minimal medium with glucose or glycerol as a carbon source. The mutant is also unable to replicate in mammalian cells and exhibits high virulence attenuation in the mouse sepsis model
malfunction
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pyruvate decarboxylase deficiency type A is characterised by hypoglycemia accompanied by mild to moderate lactic acidemia and sometimes elevated ketone body levels. Type B, having no detectable pyruvate carboxylase protein in any tissues, is the most severe form which leads to death generally within three months from lactic academia accompanied by hyperammonemia, citrullinemia and hyperlysinemia. Type C has a benign phenotype associated with episodes of lactic acidemia and no psychomotor disorders
malfunction
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a pycA insertion mutant defective in pyruvate carboxylase still grows, albeit at a reduced rate, in brain heart infusion medium but is unable to multiply in a defined minimal medium with glucose or glycerol as a carbon source. The mutant is also unable to replicate in mammalian cells and exhibits high virulence attenuation in the mouse sepsis model
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the PYC-catalyzed carboxylation of pyruvate is the predominant reaction leading to oxaloacetate in Listeria monocytogenes
metabolism
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simultaneous overexpression of isocitrate dehydrogenase (IDP1) and pyruvate carboxylase (PYC) gene PYC1 increase the amount of secreted alpha-ketoglutaric acid. About 19% more alpha-ketoglutaric acid in comparison with the control strain H355 are produced in bioreactor with raw glycerol as carbon source resulting in the highest yield of accumulated alpha-ketoglutaric acid of about 186 g/L after 117 h of cultivation
metabolism
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the PYC-catalyzed carboxylation of pyruvate is the predominant reaction leading to oxaloacetate in Listeria monocytogenes
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pyruvate carboxylase (PC) is required for glutamine-independent growth of tumor cells. PC-mediated, glucose-dependent anaplerosis allows cells to achieve glutamine independence. PC is required for cell growth during glutamine deprivation
physiological function
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pyruvate carboxylase protein is required for import and assembly of the peroxisomal enzyme alcohol oxidase
physiological function
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a gene deletion mutant shows similar morphologies to those of the wild-typewhen succinate is supplied as the carbon source. When glucose or pyruvate is provided as the carbon source, the mutation prevents growth. In the colony morphology assay, the wild type initially produces a smooth colony, which forms wrinkle structures in the centre starting on day 3. The deletion mutant and K572A colonies begin to wrinkle on day 2 and exhibit a flatter morphology with several exaggerated wrinkles in a spoke formation
physiological function
a gene disruption strain is auxotrohp for biotin due to failure to transcriptionally induce late stage biotin biosynthetic genes in low biotin conditions. Catalytically active Pyc is required and can be supported by Mycobacterium tuberculosis Pyc
physiological function
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a gene disruption strain is auxotrohp for biotin due to failure to transcriptionally induce late stage biotin biosynthetic genes in low biotin conditions. Catalytically active Pyc is required and can be supported by Mycobacterium tuberculosis Pyc
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