6.3.5.7: glutaminyl-tRNA synthase (glutamine-hydrolysing)

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For detailed information about glutaminyl-tRNA synthase (glutamine-hydrolysing), go to the full flat file.

Reaction

Synonyms

aa-tRNA amidotransferase, AdT, amidotransferase B, amidotransferase C, amidotransferase, glutamyl-transfer ribonucleate (glutamine-specific), aminoacyl-tRNA amidotransferase, BANKA_112750, gatA, GatB, GatCAB, GatCAB amidotransferase, GatDE, Gln4, GlnRS, Glu-AdT, Glu-amidotransferase, Glu-tRNAGln amidotransferase, Glu-tRNAGlnAT, GluAdT GatDE, GluRS, glutamyl-tRNA(Gln) amidotransferase, glutamyl-tRNAGln amidotransferase, nondiscriminating GluRS, PBANKA_071810, PF3D7_0416100, PF3D7_0628800, Qrsl1

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

                6.3.5.7 glutaminyl-tRNA synthase (glutamine-hydrolysing)

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Results	in table
2	Activating Compound
38513	AA Sequence
1	Application
1	CAS Registry Number
6	Cloned(Commentary)
2	Cofactor
4	Crystallization (Commentary)
7	Disease/ Diagnostics
7	General Information
6	IC50 Value
24	Inhibitors
9	kcat/KM [mM/s]
15	Ki Value [mM]
26	KM Value [mM]
5	Localization
2	Metals/Ions
6	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
31	Organism
4	Pathway
5	PDB ID
2	pH Optimum
22	Protein Variants
10	Purification (Commentary)
4	Reaction
31	Reference
1	Specific Activity [micromol/min/mg]
46	Substrates and Products (Substrate)
6	Subunits
41	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
23	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.3.5.7 - glutaminyl-tRNA synthase (glutamine-hydrolysing)

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SYSTEMATIC NAME

IUBMB Comments

L-glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)

In systems lacking discernible glutamine---tRNA ligase (EC 6.1.1.18), glutaminyl-tRNAGln is formed by a two-enzyme system. In the first step, a nondiscriminating ligase (EC 6.1.1.24, glutamate---tRNAGln ligase) mischarges tRNAGln with glutamate, forming glutamyl-tRNAGln. The glutamyl-tRNAGln is not used in protein synthesis until the present enzyme converts it into glutaminyl-tRNAGln (glutamyl-tRNAGlu is not a substrate for this enzyme). A glutaminase subunit (cf. EC 3.5.1.2, glutaminase) produces an ammonia molecule that is transferred by a 30 A tunnel to a synthase subunit, where it is ligated to the carboxy group that has been activated by phosphorylation. Some bacterial GatCAB complexes also has the activity of EC 6.3.5.6 (asparaginyl-tRNA synthase [glutamine-hydrolysing]).