6.3.5.2: GMP synthase (glutamine-hydrolysing)

This is an abbreviated version!
For detailed information about GMP synthase (glutamine-hydrolysing), go to the full flat file.

Word Map on EC 6.3.5.2

6.3.5.2

purine

glutaminase

anthranilate

imp

decoyinine

acivicin

glutamine-dependent

ammonia-dependent

gatcab

tiazofurin

6-diazo-5-oxo-l-norleucine

amidophosphoribosyltransferase

nh3-dependent

synthesis

medicine

Reaction

Synonyms

cgsA, di-GMP synthase A, EC 6.3.4.1, GATase, Glutamine amidotransferase, GMP synthase, GMP synthase [glutamine-hydrolyzing] subunit B, GMP synthetase, GMP synthetase (glutamine hydrolysing), GMPS, GUA, GuaA, Guanine monophosphate synthetase, Guanosine 5'-monophosphate synthetase, Guanosine 5-monophosphate synthetase, guanosine monophosphate synthetase, Guanosine monophosphate synthetase (glutamine-hydrolyzing), Guanylate synthetase, Guanylate synthetase (glutamine-hydrolyzing), More, PD0279, PH1346, Synthetase, guanylate, two-subunit-type GMP synthetase, Xanthosine 5'-phosphate amidotransferase, Xanthosine 5-monophosphate aminase, Xanthosine-5'-phosphate-ammonia ligase, Xanthosine-5'-phosphate:ammonia ligase (AMP-forming), Xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming), XMP aminase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

6.3.5.2 GMP synthase (glutamine-hydrolysing)

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Results	in table
5	Activating Compound
50614	AA Sequence
4	Application
2	CAS Registry Number
21	Cloned(Commentary)
6	Cofactor
7	Crystallization (Commentary)
73	Disease/ Diagnostics
8	General Information
3	General Stability
2	IC50 Value
121	Inhibitors
15	kcat/KM [mM/s]
25	Ki Value [mM]
69	KM Value [mM]
4	Localization
14	Metals/Ions
23	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
549	Organism
6	Pathway
72	PDB ID
11	pH Optimum
4	pH Range
13	Protein Variants
18	Purification (Commentary)
6	Reaction
1	Reaction Type
77	Reference
1	Renatured (Commentary)
35	Source Tissue
10	Specific Activity [micromol/min/mg]
3	Storage Stability
144	Substrates and Products (Substrate)
20	Subunits
69	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
25	Turnover Number [1/s]

KI Value

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KI Value on EC 6.3.5.2 - GMP synthase (glutamine-hydrolysing)

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0.64

(5R)-acivicin

Escherichia coli

P04079

650087

0.00041

(alpha-S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid

Escherichia coli

P04079

650087

0.0052

6-diazo-5-oxo-L-norleucine

6-Thio-GMP

0.4

8-aza-GMP

Escherichia coli

649891

0.21 - 0.611

adenosine 5'-(beta,gamma-imido)triphosphate

2 entries

0.21 - 0.611

AMP-PNP

2 entries

ATP

Mycobacterium tuberculosis

at 40°C in 50 mM Tris pH 7.5

726806

0.0364 - 933

diphosphate

6 entries

0.038 - 0.39

GMP

7 entries

0.000092

N2-hydroxyguanosine 5'-monophosphate

Escherichia coli

competitive vs XMP

649891

0.74

oxanosine

Escherichia coli

649891