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6.3.5.2: GMP synthase (glutamine-hydrolysing)

This is an abbreviated version!
For detailed information about GMP synthase (glutamine-hydrolysing), go to the full flat file.

Word Map on EC 6.3.5.2

Reaction

ATP
+
XMP
 +
L-glutamine
 +
H2O
=
AMP
 +
diphosphate
 +
GMP
 +
L-glutamate

Synonyms

cgsA, di-GMP synthase A, EC 6.3.4.1, GATase, Glutamine amidotransferase, GMP synthase, GMP synthase [glutamine-hydrolyzing] subunit B, GMP synthetase, GMP synthetase (glutamine hydrolysing), GMPS, GUA, GuaA, Guanine monophosphate synthetase, Guanosine 5'-monophosphate synthetase, Guanosine 5-monophosphate synthetase, guanosine monophosphate synthetase, Guanosine monophosphate synthetase (glutamine-hydrolyzing), Guanylate synthetase, Guanylate synthetase (glutamine-hydrolyzing), More, PD0279, PH1346, Synthetase, guanylate, two-subunit-type GMP synthetase, Xanthosine 5'-phosphate amidotransferase, Xanthosine 5-monophosphate aminase, Xanthosine-5'-phosphate-ammonia ligase, Xanthosine-5'-phosphate:ammonia ligase (AMP-forming), Xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming), XMP aminase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
                6.3.5.2 GMP synthase (glutamine-hydrolysing)

Inhibitors

Inhibitors on EC 6.3.5.2 - GMP synthase (glutamine-hydrolysing)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(5R)-acivicin
-
(alpha-S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
trivial name acivicin
1,N6-Ethenoadenosine
-
-
1,N6-Ethenoadenosine 5'-triphosphate
-
-
1-methyladenosine
-
-
1-Ribosyl-4,6-dihydroxypyrazolo[3,4-d]-pyrimidine 5'-phosphate
-
-
1-Ribosyl-4-hydroxy-6-aminopyrazolo[3,4-d]pyrimidine 5'-phosphate
-
-
2'-deoxyadenosine
-
-
2,6-diaminopurine ribonucleoside
-
-
2-Amino-6-methylthiopurine ribonucleoside
-
-
2-chloroadenosine
-
-
2-fluoroadenosine
-
-
2-fluoroinosine 5'-monophosphate
-
50% inhibition above 2 mM
2-mercaptoethanol
-
-
3'-dAMP
-
-
3'-deoxyadenosine
-
-
5'-Azido-5'-deoxyadenosine
-
-
5'-deoxyadenosine
5'-thioethyl-5'-deoxyadenosine
-
-
6-Amino-9-D-psicofuranosylpurine
6-Chloropurine ribonucleoside
-
-
6-diazo-5-oxo-L-norleucine
6-Methylmercaptopurine ribonucleoside
-
-
6-Methylpurine ribonucleoside
-
-
6-Methylpurine ribonucleotide
-
-
6-Thio-GMP
-
-
6-ThioGMP
-
-
6-thioguanine
-
0.5 mM, 27% inhibition
6-thioXMP
8-aza-GMP
-
-
8-azaadenosine
-
-
8-azaGMP
-
-
8-Azaguanine
-
0.5 mM, 40% inhibition
8-Bromoadenosine
-
-
acivicin
adenine 9-beta-D-arabinofuranoside 5'-triphosphate
-
-
adenine arabinoside
-
-
adenosine
adenosine 5'-(beta,gamma-imido)triphosphate
-
non-competitive versus XMP, competitive versus ATP
AMP-PNP
-
potent inhibitor, competitive and non-competitive inhibitor with respect to ATP and XMP
ATPgammaS
-
-
azaserine
-
-
beta,gamma-Imidoadenosine 5-triphosphate
-
-
Bredinin 5'-phosphate
-
-
Bromopyruvate
-
-
CTP
-
-
Decoyinine
diphosphate
GDP
-
0.5 mM, 42% inhibition
Glucofuranosyladenine
-
-
glutamic acid-gamma-methyl ester
-
competitive towards Gln
GTP
-
0.5 mM, 40% inhibition
guanidine hydrochloride
-
-
guanosine
-
0.5 mM, 50% inhibition
hydroxylamine
-
-
IMP
-
0.5 mM, 10% inhibition
iodoacetamide
-
inhibition of Gln-dependent activity, no inhibition of NH4+-dependent activity
kinetin ribonucleoside
-
-
L-2-Amino-4-oxo-5-chloropentanoic acid
-
inhibition of Gln-dependent activity and NH4+-dependent activity
mycophenolate
-
-
N2-hydroxyguanosine 5'-monophosphate
-
0.0003-0.0005 mM, 50% inhibition
N6,N6-Dimethyladenosine
-
-
N6-Allyladenosine
-
-
N6-Benzyladenosine
-
-
N6-Hydroxyaminopurine ribonucleoside
-
-
N6-isopentenyladenosine
-
-
N6-methyladenosine
-
-
Na+
-
25% loss of activity at 24 mM, 90% loss of activity at 200 mM
Nucleodide inhibitors
-
overview
-
oxanosine
-
-
p-chloromercuribenzoate
Psicofuranine
tubercidin
-
-
XMP
-
substrate inhibition above 0.2 mM
zeatin ribonucleoside
-
-
additional information
-
not inhibitory at 0.5 mM: hypoxanthine, chloroadenosine, xanthosine, inosine, decoyinine
-