6.3.5.10: adenosylcobyric acid synthase (glutamine-hydrolysing)

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For detailed information about adenosylcobyric acid synthase (glutamine-hydrolysing), go to the full flat file.

Reaction

4 ATP +

Synonyms

5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase, Ado-cobyric acid synthase (glutamine hydrolyzing), CbiP, cobalamin biosynthesis aminotransferase, CobQ, cobyric acid synthase, cobyric acid synthetase, More

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

                6.3.5.10 adenosylcobyric acid synthase (glutamine-hydrolysing)

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Results	in table
90	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
3	Cofactor
1	General Stability
1	Inhibitors
1	Ki Value [mM]
19	KM Value [mM]
2	Metals/Ions
8	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
13	Organism
1	Oxidation Stability
5	Pathway
4	PDB ID
3	pH Optimum
1	pI Value
4	Protein Variants
2	Purification (Commentary)
2	Reaction
12	Reference
1	Specific Activity [micromol/min/mg]
2	Storage Stability
39	Substrates and Products (Substrate)
9	Subunits
18	Synonyms
1	Systematic Name
4	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 6.3.5.10 - adenosylcobyric acid synthase (glutamine-hydrolysing)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O

adenosylcobyric acid + ADP + phosphate + L-glutamate

Escherichia coli

-

vitamin B12 biosynthesis

653832

-

653832

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

12 entries

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Halobacterium sp.

-

cobinamide biosynthesis

655868

-

-

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Halobacterium sp. NRC-1

-

cobinamide biosynthesis

655868

-

-

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Pseudomonas denitrificans (nom. rej.)

-

-

644281

-

-

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Pseudomonas denitrificans (nom. rej.)

-

biosynthesis of vitamin B12, cobalamin biosynthetic pathway

651618

-

-

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Pseudomonas denitrificans (nom. rej.)

P29932

cobalamin biosynthetic pathway, involved in coenzyme B12 synthesis

636869

-

-

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Pseudomonas denitrificans (nom. rej.)

-

CobQ is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, aerobic pathway

644278

-

-

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Pseudomonas denitrificans (nom. rej.)

-

involved in cobalamin biosynthesis

653832

-

-

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Pseudomonas denitrificans (nom. rej.) SC510 Rifr(pXL617)

P29932

cobalamin biosynthetic pathway, involved in coenzyme B12 synthesis

636869

-

-

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Pseudomonas denitrificans (nom. rej.) SC510 RifT

-

biosynthesis of vitamin B12, cobalamin biosynthetic pathway

651618

-

-

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Salmonella enterica

-

CbiP is involved in the biosynthesis of adenosylcobalamin, i.e. vitamin B12, anaerobic pathway

644278

-

-

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Salmonella enterica

-

involved in the de novo cobinamide biosynthesis pathway

655868

-

-

?

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O

ADP + phosphate + adenosylcobyric acid + L-glutamate

Salmonella enterica TR6583

-

involved in the de novo cobinamide biosynthesis pathway

655868

-

-

?