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6.3.4.5: argininosuccinate synthase

This is an abbreviated version!
For detailed information about argininosuccinate synthase, go to the full flat file.

Word Map on EC 6.3.4.5

Reaction

ATP
+
L-citrulline
 +
L-aspartate
=
AMP
 +
diphosphate
 +
2-(Nomega-L-arginino)succinate

Synonyms

ARGG, Arginine succinate synthetase, argininosuccinate synthase, argininosuccinate synthase 1, Argininosuccinate synthetase, Argininosuccinic acid synthetase, arininosuccinate synthetase, AS, ASS, ASS1, Citrulline--aspartate ligase, Citrulline-aspartate ligase, EAS, Elastin-binding protein, PyARG1, Synthetase, argininosuccinate, tAsS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.5 argininosuccinate synthase

Source Tissue

Source Tissue on EC 6.3.4.5 - argininosuccinate synthase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
human adenocarcinoma cell line Caco-2/TC7
Manually annotated by BRENDA team
more abundantly expressed in amastigotes than in promastigotes
Manually annotated by BRENDA team
-
pancreatic cancer cell line, low ASS expression level
Manually annotated by BRENDA team
Northern analyses of ass during fruiting body formation and post-harvest development reveals that expression is significantly up-regulated from developmental stage 3 on for all the tissues studied (gills, stip and cap). The expression reaches a maximum at the later stages of fruiting body growth, stages 6 and 7
Manually annotated by BRENDA team
-
pancreatic cancer cell line, low ASS expression level
Manually annotated by BRENDA team
-
in a rat ischemia model the striatum is examined at 24, 72 and 144 h after reperfusion and compared with rats in normal conditions. At 24 h after reperfusion, the number of the nitric oxide synthase-positive neurons and the percentage of those co-expressing argininosuccinate synthetase and argininsuccinate lyase and nitric oxide synthase are significantly increased in the animals with a longer survival
Manually annotated by BRENDA team
Ass1 is highly expressed in mouse decidua and uterine stromal cells undergoing decidualization, and argininosuccinate lyase Asl is weakly expressed in mouse decidua and uterine stromal cells undergoing decidualization
Manually annotated by BRENDA team
-
expression analysis is performed in bovine aortic endothelial cells (BAEC)
Manually annotated by BRENDA team
Northern analyses of ass during fruiting body formation and post-harvest development reveals that expression is significantly up-regulated from developmental stage 3 on for all the tissues studied (gills, stip and cap). The expression reaches a maximum at the later stages of fruiting body growth, stages 6 and 7
Manually annotated by BRENDA team
-
pancreatic cancer cell line, low ASS expression level
Manually annotated by BRENDA team
-
pancreatic cancer cell line, low ASS expression level
Manually annotated by BRENDA team
-
a human hepatoma cell line
Manually annotated by BRENDA team
-
parental cell line MGL8B2 and canavanine-resistant cell line MGL8D1
Manually annotated by BRENDA team
-
pancreatic cancer cell line, very low ASS expression level
Manually annotated by BRENDA team
-
extraradical myecelium
Manually annotated by BRENDA team
-
increased co-expression of AS and TNF-a mRNA is observed in non-small cell lung and stomach cancer, compared with normal corresponding tissues
Manually annotated by BRENDA team
-
pancreatic cancer cell line, very low ASS expression level
Manually annotated by BRENDA team
-
pancreatic cancer cell line, low ASS expression level
Manually annotated by BRENDA team
-
AM roots
Manually annotated by BRENDA team
-
a human epithelium cell line
Manually annotated by BRENDA team
argininosuccinate synthase accumulates in circulation within 1 h after treatment with both lipopolysaccharide alone and hepatotoxic combination of lipopolysaccharide and D-Galactosamine
Manually annotated by BRENDA team
decrease in Ass mRNA expression level during aestivation, accompanied with decreases in the concentrations of arginine and NO
Manually annotated by BRENDA team
Northern analyses of ass during fruiting body formation and post-harvest development reveals that expression is significantly up-regulated from developmental stage 3 on for all the tissues studied (gills, stip and cap). The expression reaches a maximum at the later stages of fruiting body growth, stages 6 and 7
Manually annotated by BRENDA team
-
increased co-expression of AS and TNF-a mRNA is observed in non-small cell lung and stomach cancer, compared with normal corresponding tissues
Manually annotated by BRENDA team
Ass1 is highly expressed in mouse decidua and uterine stromal cells undergoing decidualization, and argininosuccinate lyase Asl is weakly expressed in mouse decidua and uterine stromal cells undergoing decidualization
Manually annotated by BRENDA team
additional information