6.3.4.5: argininosuccinate synthase
This is an abbreviated version!
For detailed information about argininosuccinate synthase, go to the full flat file.
Word Map on EC 6.3.4.5
-
6.3.4.5
-
ornithine
-
citrullinemia
-
arginase
-
ammonia
-
hyperammonemia
-
deiminase
-
transcarbamylase
-
l-arginine
-
pegylated
-
auxotrophic
-
adi-peg20
-
carbamyl
-
adult-onset
-
coma
-
argininosuccinase
-
carbamoylphosphate
-
carbamoyltransferase
-
citrin
-
tropoelastin
-
urea-cycle
-
consciousness
-
medicine
-
ureogenesis
-
elastogenesis
-
ornithine-urea
-
elastin-derived
-
jararaca
-
coinduction
-
bothrops
-
n-acetylglutamate
-
drug development
-
molecular biology
- 6.3.4.5
- ornithine
- citrullinemia
- arginase
- ammonia
- hyperammonemia
- deiminase
-
transcarbamylase
- l-arginine
-
pegylated
-
auxotrophic
-
adi-peg20
-
carbamyl
-
adult-onset
- coma
- argininosuccinase
- carbamoylphosphate
-
carbamoyltransferase
-
citrin
- tropoelastin
-
urea-cycle
-
consciousness
- medicine
-
ureogenesis
-
elastogenesis
-
ornithine-urea
-
elastin-derived
- jararaca
-
coinduction
-
bothrops
- n-acetylglutamate
- drug development
- molecular biology
Reaction
Synonyms
ARGG, Arginine succinate synthetase, argininosuccinate synthase, argininosuccinate synthase 1, Argininosuccinate synthetase, Argininosuccinic acid synthetase, arininosuccinate synthetase, AS, ASS, ASS1, Citrulline--aspartate ligase, Citrulline-aspartate ligase, EAS, Elastin-binding protein, PyARG1, Synthetase, argininosuccinate, tAsS
ECTree
Advanced search results
General Information
General Information on EC 6.3.4.5 - argininosuccinate synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
malfunction
metabolism
physiological function
malfunction
-
epigenetic silencing triggers apoptosis in arginine auxotroph tumours
malfunction
-
malfunction results in citrullinemia type 1 argininosuccinate argininosuccinate synthetase deficiency
malfunction
a cell line lacking two of three LdASS-/-/+ alleles, with greatly reduced argininosuccinate synthase activity, is generated by a double-targeted gene replacement strategy in Leishmania donovani promastigote
malfunction
-
a cell line lacking two of three LdASS-/-/+ alleles, with greatly reduced argininosuccinate synthase activity, is generated by a double-targeted gene replacement strategy in Leishmania donovani promastigote
-
-
Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized
metabolism
the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine
metabolism
-
Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized
-
metabolism
-
the enzyme plays an important role as the rate-limiting step required for converting L-citrulline to argininosuccinate to provide arginine
-
physiological function
-
part of citrulline-NO cycle, limiting step in NO synthesis
physiological function
part of citrulline-NO cycle, limiting step in NO synthesis
physiological function
-
rate-limiting enzyme in urea and arginine(NO)-citrulline cycles
physiological function
exogenous expression of either nitric oxide synthase NOS3 or argininosuccinate synthetaseASS1 increases NO production and decreases monocyte adhesion stimulated by tumor necrosis factor-alpha. The latter effect is reduced when human umbilical vein endothelial cells are co-treated with small interfering RNAs for ASS1 or NOS3. SiRNAs of NOS3 and ASS1 attenuate the increase of NO production in human aortic endothelial cells stimulated by laminar shear stress for 24 h
physiological function
-
recombinant argininosuccinate synthase reduces lipolysaccharide cytotoxicity, TNF-alpha production, and increases cell viability in cultured mouse macrophages, even when added one h following lipopolysaccharide challenge. Intraperitoneal injection of recombinant argininosuccinate synthase at 5 mg/kg after treatment with a high dose of lipopolysaccharide remarkably increases survival of rodents, with a concomitant decrease of sepsis markers TNF-alpha, C-reactive protein, and lactate dehydrogenase levels in blood
physiological function
the enzyme is essential for parasite survival and growth in the mammalian host
physiological function
argininosuccinate synthase 1 (ASS1), is directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism. x-Ray irradiation promotes the systemic induction of Ass1 and concomitantly increases plasma arginine levels in p53+/+ mice but not in p53-/- mice. Ass1+/- mice exhibit hypersensitivity to whole-body irradiation owing to increased apoptosis in the small intestinal crypts. ASS1 plays a pivotal role in limiting Akt phosphorylation. Aberrant activation of Akt resulting from ASS1 loss disrupts Akt-mediated cell survival signaling activity under genotoxic stress
physiological function
argininosuccinate synthase ASS1 is significantly downregulated in the urine of 30 depressed subjects while remaining unchanged in the plasma
physiological function
argininosuccinate synthase is important for Leishmania donovani to survive in stressed environments and can be exploited as anti-leishmanial drug target
physiological function
-
argininosuccinate synthase is important for Leishmania donovani to survive in stressed environments and can be exploited as anti-leishmanial drug target
-