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6.3.4.5: argininosuccinate synthase

This is an abbreviated version!
For detailed information about argininosuccinate synthase, go to the full flat file.

Word Map on EC 6.3.4.5

Reaction

ATP
+
L-citrulline
 +
L-aspartate
=
AMP
 +
diphosphate
 +
2-(Nomega-L-arginino)succinate

Synonyms

ARGG, Arginine succinate synthetase, argininosuccinate synthase, argininosuccinate synthase 1, Argininosuccinate synthetase, Argininosuccinic acid synthetase, arininosuccinate synthetase, AS, ASS, ASS1, Citrulline--aspartate ligase, Citrulline-aspartate ligase, EAS, Elastin-binding protein, PyARG1, Synthetase, argininosuccinate, tAsS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.5 argininosuccinate synthase

Expression

Expression on EC 6.3.4.5 - argininosuccinate synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
argininosuccinate synthase 1 (ASS1), is directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism. x-Ray irradiation promotes the systemic induction of Ass1
Ass1 expression is upregulated significantly at implantation site on day 5 of pregnancy. Ass1 expression is induced by cAMP through PKA/p-Creb signaling pathway
downregulation of enzyme expression is associated with the development of platinum resistance to platinum-based drugs
-
gene expression is upregulated in primary human colorectal tumors
hepatic argininosuccinate synthase expression is hormonally regulated, expression of endothelial and inflammatory cell argininosuccinate synthase is under control of cytokines
-
in liver, mRNA expression levels of Ass and Asl increase significantly during the induction phase of aestivation
in the brain, changes in Ass and asl mRNA expression levels during the three phases of aestivation can be related to the supply of arginine for NO synthesis in response to conditions that resemble ischaemia and ischaemia-reperfusion during the maintenance and arousal phase of aestivation, respectively
in the kidney, there is a significant decrease in ass mRNA expression level after 6 months of aestivation. In skeletal muscle, Ass mRNA expression decreases during aestivation
increased expression in drug resistant mutant
L-Arg at high concentration down-regulates Ass1 and Asl expression by negative feedback to maintain L-Arg homeostasis
overexpression of argininosuccinate synthase in primary ovarian, stomach and colorectal cancer cells results in platinum sensitive tumours
-
threefold repression of enzyme formation by arginine
tumoural enzyme downregulation by hepatocellular carcinoma, malignant melanoma, malignant pleural mesothelioma, prostate and renal cancer
-