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6.3.4.5: argininosuccinate synthase

This is an abbreviated version!
For detailed information about argininosuccinate synthase, go to the full flat file.

Word Map on EC 6.3.4.5

Reaction

ATP
+
L-citrulline
 +
L-aspartate
=
AMP
 +
diphosphate
 +
2-(Nomega-L-arginino)succinate

Synonyms

ARGG, Arginine succinate synthetase, argininosuccinate synthase, argininosuccinate synthase 1, Argininosuccinate synthetase, Argininosuccinic acid synthetase, arininosuccinate synthetase, AS, ASS, ASS1, Citrulline--aspartate ligase, Citrulline-aspartate ligase, EAS, Elastin-binding protein, PyARG1, Synthetase, argininosuccinate, tAsS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.5 argininosuccinate synthase

Engineering

Engineering on EC 6.3.4.5 - argininosuccinate synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A192V
-
mutant G280R has no ASS activity, mutants A192V, R272C, and R304W have low ASS activity and abnormal kinetics. A higher Km for citrulline than in wild-type enzyme is obtained with mutants A192V, R272C, and R304W
D296G
mutation of the argininosuccinate synthetase gene, found in patients
E191Q
mutation of the argininosuccinate synthetase gene, found in patients
G1168A
mutation results in citrullinemia type I
G156del
mutation of the argininosuccinate synthetase gene, found in patients
G280R
-
mutant G280R has no ASS activity, mutants A192V, R272C, and R304W have low ASS activity and abnormal kinetics. A higher Km for citrulline than in wild-type enzyme is obtained with mutants A192V, R272C, and R304W
G324V
mutation of the argininosuccinate synthetase gene, found in patients
G347R
mutation of the argininosuccinate synthetase gene, found in patients
K277T
mutation of the argininosuccinate synthetase gene, found in patients
L160P
mutation of the argininosuccinate synthetase gene, found in patients
L206P
mutation of the argininosuccinate synthetase gene, found in patients
N158del
mutation of the argininosuccinate synthetase gene, found in patients
P96H
mutation of the argininosuccinate synthetase gene, found in patients
Q311del
mutation of the argininosuccinate synthetase gene, found in patients
Q401del
mutation of the argininosuccinate synthetase gene, found in patients
R127Q
mutation of the argininosuccinate synthetase gene, found in patients
R127W
mutation of the argininosuccinate synthetase gene, found in patients
R265C
mutation of the argininosuccinate synthetase gene, found in patients
R272C
-
mutant G280R has no ASS activity, mutants A192V, R272C, and R304W have low ASS activity and abnormal kinetics. A higher Km for citrulline than in wild-type enzyme is obtained with mutants A192V, R272C, and R304W
R304W
-
mutant G280R has no ASS activity, mutants A192V, R272C, and R304W have low ASS activity and abnormal kinetics. A higher Km for citrulline than in wild-type enzyme is obtained with mutants A192V, R272C, and R304W
R344del
mutation of the argininosuccinate synthetase gene, found in patients
S341F
mutation of the argininosuccinate synthetase gene, found in patients
S79P
mutation of the argininosuccinate synthetase gene, found in patients
T284I
mutation of the argininosuccinate synthetase gene, found in patients
Y291S
mutation of the argininosuccinate synthetase gene, found in patients
Y359D
mutation of the argininosuccinate synthetase gene, found in patients
additional information