6.3.4.24: tyramine-L-glutamate ligase
This is an abbreviated version!
For detailed information about tyramine-L-glutamate ligase, go to the full flat file.
Reaction
Synonyms
Mefer_1180, mfnD
ECTree
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Substrates Products
Substrates Products on EC 6.3.4.24 - tyramine-L-glutamate ligase
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REACTION DIAGRAM
ADP + phosphate + gamma-glutamyltyramine
the enzyme participates in the biosynthesis of methanofuran, a coenzymes involved in the reduction of carbon dioxide to methane
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-
?
ATP + tyramine + L-glutamate
ADP + phosphate + gamma-glutamyltyramine
maximum activity with ATP (100%). Activities with UTP (<0.2%), CTP (<0.08%), and GTP (<0.04%) are much lower. Reactions using tyrosine or phenylalanine instead of tyramine show none of the expected products. Enzymatic reactions including gamma-glutamylglutamate, pyroglutamate, or N-acetyl-glutamate instead of L-glutamate show no expected products. No activity with furyltyramine as substrate. Arg251 is an important residue for both catalysis and glutamate binding
-
-
?
ATP + tyramine + L-glutamate
ADP + phosphate + gamma-glutamyltyramine
the enzyme participates in the biosynthesis of methanofuran, a coenzymes involved in the reduction of carbon dioxide to methane
-
-
?
ATP + tyramine + L-glutamate
ADP + phosphate + gamma-glutamyltyramine
maximum activity with ATP (100%). Activities with UTP (<0.2%), CTP (<0.08%), and GTP (<0.04%) are much lower. Reactions using tyrosine or phenylalanine instead of tyramine show none of the expected products. Enzymatic reactions including gamma-glutamylglutamate, pyroglutamate, or N-acetyl-glutamate instead of L-glutamate show no expected products. No activity with furyltyramine as substrate. Arg251 is an important residue for both catalysis and glutamate binding
-
-
?