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6.3.4.19: tRNAIle-lysidine synthase

This is an abbreviated version!
For detailed information about tRNAIle-lysidine synthase, go to the full flat file.

Word Map on EC 6.3.4.19

Reaction

[tRNAIle2]-cytidine34
+
L-lysine
+
ATP
=
[tRNAIle2]-lysidine34
+
AMP
+
diphosphate
+
H2O

Synonyms

lysidine synthetase, mesJ, MesJ protein, TilS, TilS protein, tRNAIle lysidine synthetase, tRNAIle-lysidine synthetase, yacA

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.19 tRNAIle-lysidine synthase

Systematic Name

Systematic Name on EC 6.3.4.19 - tRNAIle-lysidine synthase

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SYSTEMATIC NAME
IUBMB Comments
L-lysine:[tRNAIle2]-cytidine34 ligase (AMP-forming)
The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNAIle at the oxo group in position 2 of cytidine34. This modification determines both codon and amino acid specificities of tRNAIle.