6.3.4.16: carbamoyl-phosphate synthase (ammonia)

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For detailed information about carbamoyl-phosphate synthase (ammonia), go to the full flat file.

Reaction

2 ATP +

Synonyms

arginine-specific CPS, CarB, carbamate kinase-like carbamoyl phosphate synthetase, carbamate kinase-like carbamoyl-phosphate synthetase, carbamoyl phosphate synthase-1, carbamoyl phosphate synthetase, carbamoyl phosphate synthetase 1, carbamoyl phosphate synthetase I, carbamoyl phosphate synthetase-1, carbamoyl-phosphate synthetase, carbamoyl-phosphate synthetase 1, Carbamoyl-phosphate synthetase I, Carbamoylphosphate synthase, Carbamoylphosphate synthase (ammonia), Carbamoylphosphate synthetase, Carbamoylphosphate synthetase (ammonia), Carbamoylphosphate synthetase I, carbamoylphosphate synthetase-I, Carbamyl phosphate synthase I, carbamyl phosphate synthetase I, carbamyl-phosphate synthetase I, Carbamylphosphate synthetase, carbamylphosphate synthetase 1, Carbamylphosphate synthetase I, carbmoylphosphate synthetase, Carbon-dioxide-ammonia ligase, Carbonate kinase (phosphorylating), CK-like CPS, CPS, CPS 1, CPS I, CPS I-like (ammonia- and N-acetyl-L-glutamate-dependent), CPS-1, CPS-I, CPS1, CPSase, CPSase I, CPSI, EC 2.7.2.5, mitochondrial carbamoylphosphate synthetase I, MS-s, Msm_0361, p165, urea-specific CPS

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.16 carbamoyl-phosphate synthase (ammonia)

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Results	in table
42	Activating Compound
160	AA Sequence
4	Application
1	CAS Registry Number
14	Cloned(Commentary)
18	Cofactor
4	Crystallization (Commentary)
1036	Disease/ Diagnostics
3	Expression
12	General Information
8	General Stability
39	Inhibitors
3	kcat/KM [mM/s]
4	Ki Value [mM]
64	KM Value [mM]
36	Localization
22	Metals/Ions
29	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
224	Organism
8	Pathway
12	PDB ID
12	pH Optimum
4	pH Range
3	pI Value
5	Posttranslational Modification
48	Protein Variants
17	Purification (Commentary)
10	Reaction
1	Reaction Type
84	Reference
77	Source Tissue
19	Specific Activity [micromol/min/mg]
3	Storage Stability
109	Substrates and Products (Substrate)
14	Subunits
90	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
11	Temperature Stability [°C]
8	Turnover Number [1/s]

Expression

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Expression on EC 6.3.4.16 - carbamoyl-phosphate synthase (ammonia)

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

human hepatocellular carcinoma cells do not express CPS1, whereas cultured human primary hepatocytes express abundant levels. CPS1 is silenced or down-regulated in liver tumor tissues compared with the matched noncancerous tissues. The expression of CPS1 in human hepatocellular carcinoma cells is restored with demethylation agent, 5-azacytidine. Two CpG dinucleotides, located near the transcription start site, and a CpG-rich region in the first intron are hypermethylated in human hepatocellular carcinoma cells

Homo sapiens

P31327

713715

nobiletin is able to lower serum ammonia levels in mice fed with regular chow (RC), high-fat (HFD) or high-protein diet. NOB rescues CPS1 protein levels under the HFD condition via induction of the transcription factors C/EBPalpha and C/EBPbeta. HPD markedly increases CPS1 levels relative to RC. A functional circadian clock, is required for nobiletin induction of CPS1 under the HFD condition

Mus musculus

Q8C196

745931

nutrient depletion does not increase CPS1 protein levels in wild-type or KO cells

Mus musculus

-

703149