6.3.4.16: carbamoyl-phosphate synthase (ammonia)

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For detailed information about carbamoyl-phosphate synthase (ammonia), go to the full flat file.

Reaction

2 ATP +

Synonyms

arginine-specific CPS, CarB, carbamate kinase-like carbamoyl phosphate synthetase, carbamate kinase-like carbamoyl-phosphate synthetase, carbamoyl phosphate synthase-1, carbamoyl phosphate synthetase, carbamoyl phosphate synthetase 1, carbamoyl phosphate synthetase I, carbamoyl phosphate synthetase-1, carbamoyl-phosphate synthetase, carbamoyl-phosphate synthetase 1, Carbamoyl-phosphate synthetase I, Carbamoylphosphate synthase, Carbamoylphosphate synthase (ammonia), Carbamoylphosphate synthetase, Carbamoylphosphate synthetase (ammonia), Carbamoylphosphate synthetase I, carbamoylphosphate synthetase-I, Carbamyl phosphate synthase I, carbamyl phosphate synthetase I, carbamyl-phosphate synthetase I, Carbamylphosphate synthetase, carbamylphosphate synthetase 1, Carbamylphosphate synthetase I, carbmoylphosphate synthetase, Carbon-dioxide-ammonia ligase, Carbonate kinase (phosphorylating), CK-like CPS, CPS, CPS 1, CPS I, CPS I-like (ammonia- and N-acetyl-L-glutamate-dependent), CPS-1, CPS-I, CPS1, CPSase, CPSase I, CPSI, EC 2.7.2.5, mitochondrial carbamoylphosphate synthetase I, MS-s, Msm_0361, p165, urea-specific CPS

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.16 carbamoyl-phosphate synthase (ammonia)

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42	Activating Compound
160	AA Sequence
4	Application
1	CAS Registry Number
14	Cloned(Commentary)
18	Cofactor
4	Crystallization (Commentary)
1036	Disease/ Diagnostics
3	Expression
12	General Information
8	General Stability
39	Inhibitors
3	kcat/KM [mM/s]
4	Ki Value [mM]
64	KM Value [mM]
36	Localization
22	Metals/Ions
29	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
224	Organism
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48	Protein Variants
17	Purification (Commentary)
10	Reaction
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84	Reference
77	Source Tissue
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109	Substrates and Products (Substrate)
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11	Temperature Stability [°C]
8	Turnover Number [1/s]

Crystallization

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Crystallization on EC 6.3.4.16 - carbamoyl-phosphate synthase (ammonia)

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

structures of CPS1 in the absence and in the presence of N-acetyl-L-glutamate. N-acetyl-L-glutamate binds at the C-terminal domain of CPS1 and triggers long-range conformational changes affecting the two distant phosphorylation domains. The changes, concerted with the binding of nucleotides, result in a remodeling that stabilizes the catalytically competent conformation and the building of an about 35 A long tunnel that allows migration of the carbamate intermediate to the second phosphorylation site, where carbamoyl phosphate is produced

Homo sapiens

P31327

745438

-

Lithobates catesbeianus

-

1465

1.5 A resolution structure of recombinant enzyme

Pyrococcus furiosus

-

642229

recombinant enzyme

Pyrococcus furiosus

-

642230