6.3.4.16: carbamoyl-phosphate synthase (ammonia)

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For detailed information about carbamoyl-phosphate synthase (ammonia), go to the full flat file.

Reaction

2 ATP +

Synonyms

arginine-specific CPS, CarB, carbamate kinase-like carbamoyl phosphate synthetase, carbamate kinase-like carbamoyl-phosphate synthetase, carbamoyl phosphate synthase-1, carbamoyl phosphate synthetase, carbamoyl phosphate synthetase 1, carbamoyl phosphate synthetase I, carbamoyl phosphate synthetase-1, carbamoyl-phosphate synthetase, carbamoyl-phosphate synthetase 1, Carbamoyl-phosphate synthetase I, Carbamoylphosphate synthase, Carbamoylphosphate synthase (ammonia), Carbamoylphosphate synthetase, Carbamoylphosphate synthetase (ammonia), Carbamoylphosphate synthetase I, carbamoylphosphate synthetase-I, Carbamyl phosphate synthase I, carbamyl phosphate synthetase I, carbamyl-phosphate synthetase I, Carbamylphosphate synthetase, carbamylphosphate synthetase 1, Carbamylphosphate synthetase I, carbmoylphosphate synthetase, Carbon-dioxide-ammonia ligase, Carbonate kinase (phosphorylating), CK-like CPS, CPS, CPS 1, CPS I, CPS I-like (ammonia- and N-acetyl-L-glutamate-dependent), CPS-1, CPS-I, CPS1, CPSase, CPSase I, CPSI, EC 2.7.2.5, mitochondrial carbamoylphosphate synthetase I, MS-s, Msm_0361, p165, urea-specific CPS

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.16 carbamoyl-phosphate synthase (ammonia)

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Results	in table
42	Activating Compound
160	AA Sequence
4	Application
1	CAS Registry Number
14	Cloned(Commentary)
18	Cofactor
4	Crystallization (Commentary)
1036	Disease/ Diagnostics
3	Expression
12	General Information
8	General Stability
39	Inhibitors
3	kcat/KM [mM/s]
4	Ki Value [mM]
64	KM Value [mM]
36	Localization
22	Metals/Ions
29	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
224	Organism
8	Pathway
12	PDB ID
12	pH Optimum
4	pH Range
3	pI Value
5	Posttranslational Modification
48	Protein Variants
17	Purification (Commentary)
10	Reaction
1	Reaction Type
84	Reference
77	Source Tissue
19	Specific Activity [micromol/min/mg]
3	Storage Stability
109	Substrates and Products (Substrate)
14	Subunits
90	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
11	Temperature Stability [°C]
8	Turnover Number [1/s]

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Application on EC 6.3.4.16 - carbamoyl-phosphate synthase (ammonia)

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

analysis

Homo sapiens

P31327

development of a CPS1-reporter system for the assessment of ammonia metabolism. Labeling of CPS1 gene in cell lines HepG2, and LO2, with fluorescence protein. Cellular detoxification enhancers are selected among a collection of 182 small molecules. In both CPS1 reporter cell lines, the fluorescence intensity is positively correlated with cellular CPS1 mRNA expression, ammonia elimination and secreted urea, and reflects ammonia detoxification in a dose-dependent manner

745438

biotechnology

Sus scrofa

-

ammonia elimination as functional marker in hepatocyte cultivation and zonation in a bioreactor, and construction of a bioartificial liver, overview

691725

medicine

2 entries

medicine

Homo sapiens

P31327

human hepatocellular carcinoma cells do not express CPS1, whereas cultured human primary hepatocytes express abundant levels. CPS1 is silenced or down-regulated in liver tumor tissues compared with the matched noncancerous tissues. The expression of CPS1 in human hepatocellular carcinoma cells is restored with demethylation agent, 5-azacytidine. Two CpG dinucleotides, located near the transcription start site, and a CpG-rich region in the first intron are hypermethylated in human hepatocellular carcinoma cells

713715

medicine

Homo sapiens

P31327

upregulation of CPS1 gene most significantly predicts poor response to neoadjuvant concurrent chemoradiotherapy. CPS1 overexpression is significantly related to advanced posttreatment tumor and nodal status, and inferior tumor regression grade. CPS1 overexpression is significantly associated with shorter disease-specific survival and metastasis-free survival. CPS1 protein expression is more abundant in colon cancer cells than nonneoplastic HCoEpiC

746546