Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

6.3.4.16: carbamoyl-phosphate synthase (ammonia)

This is an abbreviated version!
For detailed information about carbamoyl-phosphate synthase (ammonia), go to the full flat file.

Word Map on EC 6.3.4.16

Reaction

2 ATP +

NH3
+
hydrogencarbonate
=
2 ADP
 +
phosphate
 +
Carbamoyl phosphate

Synonyms

arginine-specific CPS, CarB, carbamate kinase-like carbamoyl phosphate synthetase, carbamate kinase-like carbamoyl-phosphate synthetase, carbamoyl phosphate synthase-1, carbamoyl phosphate synthetase, carbamoyl phosphate synthetase 1, carbamoyl phosphate synthetase I, carbamoyl phosphate synthetase-1, carbamoyl-phosphate synthetase, carbamoyl-phosphate synthetase 1, Carbamoyl-phosphate synthetase I, Carbamoylphosphate synthase, Carbamoylphosphate synthase (ammonia), Carbamoylphosphate synthetase, Carbamoylphosphate synthetase (ammonia), Carbamoylphosphate synthetase I, carbamoylphosphate synthetase-I, Carbamyl phosphate synthase I, carbamyl phosphate synthetase I, carbamyl-phosphate synthetase I, Carbamylphosphate synthetase, carbamylphosphate synthetase 1, Carbamylphosphate synthetase I, carbmoylphosphate synthetase, Carbon-dioxide-ammonia ligase, Carbonate kinase (phosphorylating), CK-like CPS, CPS, CPS 1, CPS I, CPS I-like (ammonia- and N-acetyl-L-glutamate-dependent), CPS-1, CPS-I, CPS1, CPSase, CPSase I, CPSI, EC 2.7.2.5, mitochondrial carbamoylphosphate synthetase I, MS-s, Msm_0361, p165, urea-specific CPS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.16 carbamoyl-phosphate synthase (ammonia)

Activating Compound

Activating Compound on EC 6.3.4.16 - carbamoyl-phosphate synthase (ammonia)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetylglutamate
dimethyl sulfoxide
-
activates in absence of the activator acetylglutamate
ethylene glycol
-
activates in absence of the activator acetylglutamate
glycerol
inosine monophosphate
-
weak activator, the IMP binding site is located at the C-terminus, binding structure analysis from crystal structure with bound IMP, PDB ID 1CE8
L-alanine
-
infusion of alanine at 50% of resting energy expenditure for 36 h increases the enzyme activity more than twofold
N-acetyl-L-beta-phenylglutamate
lower activation of CPSI compared to N-acetyl-L-glutamate
N-acetyl-L-glutamate
N-acetylglutamate
N-carbamoylglutamate
-
effective activator, Km: 2.0 mM
N-carbamyl-L-glutamate
-
ornithine
-
-
SIRT5
-
sucrose
-
activates in absence of the activator acetylglutamate
additional information
-
not: UTP
-