6.3.4.15: biotin-[biotin carboxyl-carrier protein] ligase

This is an abbreviated version!
For detailed information about biotin-[biotin carboxyl-carrier protein] ligase, go to the full flat file.

Reaction

Synonyms

Acetyl CoA holocarboxylase synthetase, Acetyl coenzyme A holocarboxylase synthetase, bacterial BirA biotin ligase, biotin acetyl-CoA carboxylase ligase, Biotin holoenzyme synthetase, biotin ligase, biotin protein ligase, Biotin--protein ligase, biotin-protein ligase, Biotin-[acetyl coenzyme A carboxylase] synthetase, Biotin-[acetyl-CoA carboxylase] synthetase, Biotin:apocarboxylase ligase, BirA, BirA protein, BPL, group I biotin protein ligase, HCS, Holocarboxylase synthetase, holocarboxylase synthetase 1, More, STK_15250, Synthetase, biotin-[acetyl coenzyme A carboxylase], yBL

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.15 biotin-[biotin carboxyl-carrier protein] ligase

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Results	in table
32398	AA Sequence
16	Application
1	CAS Registry Number
38	Cloned(Commentary)
68	Cofactor
14	Crystallization (Commentary)
24	Disease/ Diagnostics
16	General Information
3	IC50 Value
28	Inhibitors
13	kcat/KM [mM/s]
13	Ki Value [mM]
53	KM Value [mM]
10	Localization
30	Metals/Ions
17	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
411	Organism
5	Pathway
94	PDB ID
9	pH Optimum
68	Protein Variants
31	Purification (Commentary)
4	Reaction
3	Reaction Type
99	Reference
15	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
149	Substrates and Products (Substrate)
30	Subunits
140	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
6	Temperature Stability [°C]
39	Turnover Number [1/s]

Disease

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Disease on EC 6.3.4.15 - biotin-[biotin carboxyl-carrier protein] ligase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Adenocarcinoma of Lung

Exploring a Tumor-Intrinsic PD-L1 Signal with Proximity-Dependent Biotin Identification in Lung Cancer Cells.

31021072

Cysts

The Toxoplasma gondii Cyst Wall Interactome.

32019789

Dengue

Expression, purification and characterization of in vivo biotinylated dengue virus envelope domain III based tetravalent antigen.

20435144

Infections

A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases.

25118235

Infections

Development of a novel bacteriophage based biomagnetic separation method as an aid for sensitive detection of viable Escherichia coli.

26689710

Infections

Simultaneous protein expression and modification: an efficient approach for production of unphosphorylated and biotinylated receptor tyrosine kinases by triple infection in the baculovirus expression system.

20357977

Infections

The root-invading pathogen Fusarium oxysporum targets pattern-triggered immunity using both cytoplasmic and apoplastic effectors.

32323328

Lipoma

Biotin ligase tagging identifies proteins proximal to E-cadherin, including lipoma preferred partner, a regulator of epithelial cell-cell and cell-substrate adhesion.

24338363

Tuberculosis

Crystallization and preliminary X-ray diffraction analysis of biotin acetyl-CoA carboxylase ligase (BirA) from Mycobacterium tuberculosis.

18540066

Tuberculosis

Ligand specificity of group I biotin protein ligase of Mycobacterium tuberculosis.

18509457

Tuberculosis

Mycobacterium smegmatis?BioQ defines a new regulatory network for biotin metabolism.

25287944

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