6.3.3.4: (carboxyethyl)arginine beta-lactam-synthase
This is an abbreviated version!
For detailed information about (carboxyethyl)arginine beta-lactam-synthase, go to the full flat file.
Reaction
Synonyms
beta-lactam-forming enzyme, beta-lactam-synthetase, betaLS, bls2, synthetase, beta-lactam
ECTree
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Systematic Name
Systematic Name on EC 6.3.3.4 - (carboxyethyl)arginine beta-lactam-synthase
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L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming)
Forms part of the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. It has been proposed [3] that L-N2-(2-carboxyethyl)arginine is first converted into an acyl-AMP by reaction with ATP and loss of diphosphate, and that the beta-lactam ring is then formed by the intramolecular attack of the beta-nitrogen on the activated carboxy group.