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6.3.3.4: (carboxyethyl)arginine beta-lactam-synthase

This is an abbreviated version!
For detailed information about (carboxyethyl)arginine beta-lactam-synthase, go to the full flat file.

Reaction

ATP
+
L-N2-(2-carboxyethyl)arginine
=
AMP
+
diphosphate
+
deoxyamidinoproclavaminate

Synonyms

beta-lactam-forming enzyme, beta-lactam-synthetase, betaLS, bls2, synthetase, beta-lactam

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.3 Cyclo-ligases
                6.3.3.4 (carboxyethyl)arginine beta-lactam-synthase

Systematic Name

Systematic Name on EC 6.3.3.4 - (carboxyethyl)arginine beta-lactam-synthase

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SYSTEMATIC NAME
IUBMB Comments
L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming)
Forms part of the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. It has been proposed [3] that L-N2-(2-carboxyethyl)arginine is first converted into an acyl-AMP by reaction with ATP and loss of diphosphate, and that the beta-lactam ring is then formed by the intramolecular attack of the beta-nitrogen on the activated carboxy group.