6.3.3.2: 5-formyltetrahydrofolate cyclo-ligase

This is an abbreviated version!
For detailed information about 5-formyltetrahydrofolate cyclo-ligase, go to the full flat file.

Word Map on EC 6.3.3.2

6.3.3.2

mthfr

methylenetetrahydrofolate

one-carbon

homocysteine

folate-dependent

slc19a1

10-formyltetrahydrofolate

trifunctional

cyclohydrolase

5,10-methylenetetrahydrofolate

remethylation

folate-mediated

folate-related

1-carbon

megaloblastic

periconceptional

folate-metabolizing

analysis

pharmacology

medicine

Reaction

Synonyms

5,10-methenyl-tetrahydrofolate synthetase, 5,10-Methenyltetrahydrofolate synthetase, 5,10-Methenyltetrahydropteroylglutamate synthetase, 5-CHO-THF cycloligase, 5-FCL, 5-Formyltetrahydrofolate cyclodehydrase, CH+-THF synthetase, Fau1p, Formyltetrahydrofolic cyclodehydrase, Methenyl THFS, Methenyl-THF synthetase, Methenyltetrahydrofolate synthetase, More, MTHFD1, MTHFS, N5-Formyltetrahydrofolic acid cyclodehydrase, Synthetase, methenyltetrahydrofolate, ygfA

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.3 Cyclo-ligases

6.3.3.2 5-formyltetrahydrofolate cyclo-ligase

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4	Activating Compound
36539	AA Sequence
4	Application
1	CAS Registry Number
19	Cloned(Commentary)
16	Cofactor
4	Crystallization (Commentary)
470	Disease/ Diagnostics
1	Expression
5	General Information
4	General Stability
6	IC50 Value
49	Inhibitors
18	Ki Value [mM]
76	KM Value [mM]
15	Localization
27	Metals/Ions
19	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
48	Organism
1	Oxidation Stability
7	Pathway
12	PDB ID
11	pH Optimum
2	pH Range
2	pH Stability
38	Protein Variants
20	Purification (Commentary)
9	Reaction
7	Reaction Type
48	Reference
53	Source Tissue
20	Specific Activity [micromol/min/mg]
3	Storage Stability
98	Substrates and Products (Substrate)
15	Subunits
66	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
4	Temperature Stability [°C]
26	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 6.3.3.2 - 5-formyltetrahydrofolate cyclo-ligase

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5-formyltetrahydrofolate polyglutamate

Homo sapiens

induced recombinant enzyme expression in cancer cell cultures, increasing effect with increasing chain length

652430

dopamine

Mus musculus

0.02 mM, increases the initial rapid phase of folate turnover by 4%

671613

N-acetyldopamine

Mus musculus

0.02 mM, accelerates markedly folate turnover

671613

additional information

Mus musculus

L-dopa does not affect folate turnover rate

671613