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6.3.3.1: phosphoribosylformylglycinamidine cyclo-ligase

This is an abbreviated version!
For detailed information about phosphoribosylformylglycinamidine cyclo-ligase, go to the full flat file.

Word Map on EC 6.3.3.1

Reaction

ATP
+
2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine
=
ADP
 +
phosphate
 +
5-amino-1-(5-phospho-D-ribosyl)imidazole

Synonyms

5'-Aminoimidazole ribonucleotide synthetase, 5'-Phosphoribosyl-5-aminoimidazole synthetase, AIR synthase, AIR synthetase, AIRS, aminoimidazole ribonucleotide synthetase, phosphoribosyl aminoimidazole synthetase, Phosphoribosyl-aminoimidazole synthetase, Phosphoribosylaminoimidazole synthetase, PurM, Synthetase, phosphoribosylaminoimidazole

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.3 Cyclo-ligases
                6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase

Cloned

Cloned on EC 6.3.3.1 - phosphoribosylformylglycinamidine cyclo-ligase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning and characterization of a 12-gene cluster encoding nine enzymes for de novo purine nucleotide synthesis. The cluster is likely an operon and is organized into three groups of overlapping genes followed by the last gene: purEKB-purC(or)QLF-purMNH(J)-purD
-
expression in Escherichia coli
-
expression in Escherichia coli of a histidine-tagged enzyme
expression in Escherichia coli of a histidine-tagged recombinant enzyme
expression in Saccharomyces cerevisiae
-
expression of recombinant enzymes in Escherichia coli
expression of the trifunctional enzyme with AIR synthetase activity, phosphoribosylglycinamide synthetase activity, and phosphoribosylglycinamide transformylase activity, in mutant CHO cells
-