6.3.2.B15: 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine-L-valine ligase

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For detailed information about 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine-L-valine ligase, go to the full flat file.

Reaction

(2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate

N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-isoleucine

Synonyms

DdaF

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.B15 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine-L-valine ligase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
1	General Information
6	kcat/KM [mM/s]
5	KM Value [mM]
5	Natural Substrates/ Products (Substrates)
3	Organism
2	pH Optimum
1	Purification (Commentary)
4	Reaction
3	Reference
13	Substrates and Products (Substrate)
3	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 6.3.2.B15 - 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine-L-valine ligase

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ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-isoleucine

ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-isoleucine

2 entries

ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-leucine

ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-leucine

2 entries

ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-valine

ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-valine

2 entries

ATP + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + L-valine

ADP + phosphate + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanyl-L-valine

2 entries

ATP + Nbeta-(R,R)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionate + L-valine

ADP + phosphate + Nbeta-(R,R)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionyl-L-valine

2 entries

ATP + Nbeta-(S,S)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionate + L-valine

ADP + phosphate + Nbeta-(S,S)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionyl-L-valine

Pantoea agglomerans

E2JA31

kcat/Km for the (S,S)-stereoisomer is 2.5% compared to the kcat/Km-value for the (R,R)-stereoisomer. Nbeta-(S,S)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionate i.e. 3-[[[(2S,3S)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine

729882

additional information

Pantoea agglomerans

E2JA31

no activity with Nbeta-fumaroyl-(2S)-2,3-diaminopropionate

729202