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6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase, go to the full flat file.

Word Map on EC 6.3.2.7

Reaction

ATP
+
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
+
L-lysine
=
ADP
+
phosphate
+
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine

Synonyms

MuE, MurE, Synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase, uridine 5'-diphospho-N-acetylmuramoyl L-alanyl-D-glutamate:lysine ligase, Uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

Reference

Reference on EC 6.3.2.7 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Linnett, P.E.; Tipper, D.J.
Cell wall polymers of Bacillus sphaericus: activities of enzymes involved in peptidoglycan precursor synthesis during sporulation
J. Bacteriol.
120
342-354
1974
Lysinibacillus sphaericus
Manually annotated by BRENDA team
Tipper, D.J.; Linnett, P.E.
Distribution of peptidoglycan synthetase activities between sporangia and forespores in sporulating cells of Bacillus sphaericus
J. Bacteriol.
126
213-221
1976
Lysinibacillus sphaericus, Lysinibacillus sphaericus 9602
Manually annotated by BRENDA team
Anwar, R.A.; Vlaovic, M.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase from Bacillus sphaericus: activation by potassium phosphate
Biochem. Cell Biol.
64
297-303
1986
Lysinibacillus sphaericus
Manually annotated by BRENDA team
Chatterjee, A.N.; Young, F.E.
Regulation of the bacterial cell wall: isolation and characterization of peptidoglycan mutants of Staphylococcus aureus
J. Bacteriol.
111
220-230
1972
Staphylococcus aureus
Manually annotated by BRENDA team
Good, C.M.; Tipper, D.J.
Conditional mutants of Staphylococcus aureus defective in cell wall precursor synthesis
J. Bacteriol.
111
231-241
1972
Staphylococcus aureus
Manually annotated by BRENDA team
Ito, E.; Strominger, J.L.
Enzymatic synthesis of the peptide in bacterial uridine nucleotides. I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine
J. Biol. Chem.
237
2689-2695
1962
Staphylococcus aureus
-
Manually annotated by BRENDA team
Mengin-Lecreulx, D.; Falla, T.; Blanot, D.; van Heijenoort, J.; Adams, D.J.; Chopra, I.
Expression of the Staphylococcus aureus UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine ligase in Escherichia coli and effects on peptidoglycan biosynthesis and cell growth
J. Bacteriol.
181
5909-5914
1999
Staphylococcus aureus
Manually annotated by BRENDA team
Blewett, A.M.; Lloyd, A.J.; Echalier, A.; Fulop, V.; Dowson, C.G.; Bugg, T.D.; Roper, D.I.
Expression, purification, crystallization and preliminary characterization of uridine 5'-diphospho-N-acetylmuramoyl L-alanyl-D-glutamate:lysine ligase (MurE) from Streptococcus pneumoniae 110K/70
Acta Crystallogr. Sect. D
60
359-361
2004
Streptococcus pneumoniae
Manually annotated by BRENDA team
Triolo, T.A.; Chabin, R.M.; Pompliano, D.L.
Cloning, expression and characterization of the Streptococcus pyogenes murE gene encoding a UDP-MurNAc-L-alanyl-D-glutamate: L-lysine ligase
Enzyme Microb. Technol.
35
300-308
2004
Streptococcus pyogenes
-
Manually annotated by BRENDA team
Strancar, K.; Boniface, A.; Blanot, D.; Gobec, S.
Phosphinate inhibitors of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase (MurE)
Arch. Pharm.
340
127-134
2007
Staphylococcus aureus
Manually annotated by BRENDA team
Patin, D.; Boniface, A.; Kovac, A.; Hervé, M.; Dementin, S.; Barreteau, H.; Mengin-Lecreulx, D.; Blanot, D.
Purification and biochemical characterization of Mur ligases from Staphylococcus aureus
Biochimie
92
1793-1800
2010
Staphylococcus aureus
Manually annotated by BRENDA team
Zivec, M.; Turk, S.; Blanot, D.; Gobec, S.
Design and synthesis of new peptidomimetics as potential inhibitors of MurE
Acta Chim. Slov.
58
95-109
2011
Staphylococcus aureus
Manually annotated by BRENDA team
Ruane, K.M.; Lloyd, A.J.; Fueloep, V.; Dowson, C.G.; Barreteau, H.; Boniface, A.; Dementin, S.; Blanot, D.; Mengin-Lecreulx, D.; Gobec, S.; Dessen, A.; Roper, D.I.
Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex
J. Biol. Chem.
288
33439-33448
2013
Staphylococcus aureus (Q2FZP6)
Manually annotated by BRENDA team