6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase, go to the full flat file.

Reaction

Synonyms

MuE, MurE, Synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase, uridine 5'-diphospho-N-acetylmuramoyl L-alanyl-D-glutamate:lysine ligase, Uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
1481	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
2	Cofactor
2	Crystallization (Commentary)
2	General Information
2	IC50 Value
48	Inhibitors
5	kcat/KM [mM/s]
20	KM Value [mM]
12	Metals/Ions
5	Natural Substrates/ Products (Substrates)
16	Organism
5	Pathway
4	PDB ID
5	pH Optimum
1	pH Range
2	pH Stability
1	pI Value
6	Protein Variants
6	Purification (Commentary)
1	Reaction
2	Reaction Type
14	Reference
4	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
19	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 6.3.2.7 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu + L-Lys

?

Lysinibacillus sphaericus

-

one step in the biosynthesis of bacterial cell walls

1270

-

-

?

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine

ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine

2 entries

additional information

?

-

2 entries

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine

ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine

Staphylococcus aureus

-

-

726560

-

-

?

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine

ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine

Staphylococcus aureus

Q2FZP6

the enzyme of the Gram-positive bacterium discriminates between L-lysine and D,L-diaminopimelic acid, the predominant amino acid that replaces L-lysine in Gram-negative peptidoglycan. Despite the absolute specificity for L-lysine, Staphylococcus aureus MurE binds this substrate relatively poorly. In vivo analysis and metabolomic data reveal that this is compensated for by high cytoplasmic L-lysine concentrations

727964

-

-

?

additional information

?

-

Staphylococcus aureus

Q2FZP6

the third amino acid added to the peptide stem of peptidoglycan is usually either meso-diaminopimelic acid (in most Gram-negative bacteria), EC 6.3.2.13, or L-lysine (in most Gram-positive bacteria), EC 6.3.2.7

727964

-

-

?

additional information

?

-

Staphylococcus aureus

-

the third amino acid added to the peptide stem of peptidoglycan is usually either meso-diaminopimelic acid (in most Gram-negative bacteria), EC 6.3.2.13, or L-lysine (in most Gram-positive bacteria), EC 6.3.2.7, although in some cases other amino acids are found at this position

726560

-

-

?