6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
This is an abbreviated version!
For detailed information about UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase, go to the full flat file.
Reaction
+
+
=
+
+
Synonyms
MuE, MurE, Synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase, uridine 5'-diphospho-N-acetylmuramoyl L-alanyl-D-glutamate:lysine ligase, Uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase
ECTree
KM Value
KM Value on EC 6.3.2.7 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
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0.087 - 0.59
UDP-N-acetylmuramoyl-L-Ala-D-Glu
0.125
ATP
-
23°C
0.52
ATP
-
in presence of 2 mM K2HPO4
0.55
ATP
-
in presence of 30 mM K2HPO4
0.0205
L-Lys
-
23°C
0.55
L-Lys
-
pH 8.6, 37°C
0.55
L-lysine
pH 8.6, 37°C, recombinant wild-type enzyme
2.8
L-lysine
pH 8.6, 37°C, recombinant mutant D406A
3.1
L-lysine
pH 8.6, 37°C, recombinant mutant P408A
20
L-lysine
above, pH 8.6, 37°C, recombinant mutant A409R
20
L-lysine
above, pH.6, 37°C, recombinant mutant E460A
0.37
Lys
-
in presence of 30 mM K2HPO4
0.42
Lys
-
in presence of 2 mM K2HPO4
0.44
Lys
-
in presence of 60 mM KCl
0.49
Lys
-
in presence of 60 mM KCl
0.087
UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
pH 8.6, 37°C
0.122
UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
23°C
0.53
UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
in presence of 30 mM K2HPO4
0.57
UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
in presence of 2 mM K2HPO4
0.59
UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
in presence of 60 mM KCl