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6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase, go to the full flat file.

Word Map on EC 6.3.2.7

Reaction

ATP
+
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
 +
L-lysine
=
ADP
 +
phosphate
 +
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine

Synonyms

MuE, MurE, Synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase, uridine 5'-diphospho-N-acetylmuramoyl L-alanyl-D-glutamate:lysine ligase, Uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

Inhibitors

Inhibitors on EC 6.3.2.7 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R)-2-amino-6-([[(3R)-3-carboxy-3-([N-[6-(phosphonooxy)hexanoyl]-L-alanyl]amino)propyl](hydroxy)phosphoryl]methyl)heptanedioic acid
-
-
(2R)-2-amino-6-([[(3R)-3-carboxy-3-[[N-(6-[[[[[[(2R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methoxy](hydroxy)phosphoryl]oxy](hydroxy)phosphoryl]oxy]hexanoyl)-L-alanyl]amino]propyl](hydroxy)phosphoryl]methyl)heptanedioic acid
-
-
(6S,9R,14S)-benzyl 9-benzyloxycarbonyl-14-(4-benzyloxycarbonylaminobutyl)-2,2,6-trimethyl-4,7-dioxo-3-oxa-5,8,13-triazapentadecan-15-oate
-
-
(R)-2-[bis(tert-butoxycarbonyl)amino]-5-oxopentanoate
-
-
(R)-benzyl 2-[(tert-butoxycarbonyl)amino]-5-[methoxy(methyl)amino]-5-oxopentanoate
-
-
(R)-benzyl 2-[bis(tert-butoxycarbonyl)amino]-5-[methoxy(methyl)amino]-5-oxopentanoate
-
-
(S)-1-(2-tert-butoxycarbonylaminopropanoyl)piperidine-4-carboxylic acid
-
-
(S)-6-amino-2-((R)-4-amino-4-carboxybutylamino)hexanoic acid
-
-
(S)-6-amino-2-(piperidine-4-carboxamido)hexanoic acid
-
-
(S)-6-amino-2-([[1-((S)-2-aminopropanoyl)piperidin-4-yl]methyl]amino)hexanoic acid
-
-
(S)-6-amino-2-[(piperidin-4-ylmethyl)amino]hexanoic acid
-
-
(S)-6-amino-2-[1-((S)-2-aminopropanoyl)piperidine-4-carboxamido]hexanoic acid 2,2,2-trifluoroacetate
-
-
(S)-6-amino-2-[1-(carboxymethyl)piperidine-4-carboxamido]hexanoic acid
-
-
(S)-6-amino-2-[[(R)-4-((S)-2-aminopropanamido)-4-carboxybutyl]amino]hexanoic acid
-
-
(S)-benzyl 1-(2-tert-butoxycarbonylaminopropanoyl)piperidine-4-carboxylate
-
-
(S)-benzyl 2-([(R)-5-(benzyloxy)-4-[bis(tert-butoxycarbonyl)amino]-5-oxopentyl]amino)-6-benzyloxycarbonylaminohexanoate
-
-
(S)-benzyl 6-benzyloxycarbonylamino-2-[([1-[(S)-2-(tert-butoxycarbonylamino)propanoyl]piperidin-4-yl]methyl)amino]hexanoate
-
-
(S)-benzyl 6-benzyloxycarbonylamino-2-[1-((S)-2-tertbutoxycarbonylaminopropanoyl)piperidine-4-carboxamido]hexanoate
-
-
(S)-benzyl 6-benzyloxycarbonylamino-2-[1-(2-tertbutoxy-2-oxoethyl)piperidine-4-carboxamido]hexanoate
-
-
(S)-N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)piperidine-4-carboxamide
-
-
(S)-tert-butyl 4-[(1-benzyloxy-6-benzyloxycarbonylamino-1-oxohexan-2-yl)carbamoyl]piperidine-1-carboxylate
-
-
(S)-tert-butyl 4-[[(1-benzyloxy-6-benzyloxycarbonylamino-1-oxohexan-2-yl)amino]methyl]piperidine-1-carboxylate
-
-
1-(2-tert-butoxy-2-oxoethyl)piperidine-4-carboxylic acid
-
-
2-([hydroxy[1-([N-[(4-nitrobenzyl)sulfonyl]-D-alanyl]amino)ethyl]phosphoryl]methyl)pentanedioic acid
-
1 mM, 13% residual activity
2-[[(1-[[(2E)-3-(1,3-benzodioxol-5-yl)prop-2-enoyl]amino]ethyl)(hydroxy)phosphoryl]methyl]pentanedioic acid
-
1 mM, 52% residual activity
2-[[(1-[[(benzyloxy)carbonyl]amino]ethyl)(hydroxy)phosphoryl]methyl]pentanedioic acid
-
1 mM, 35% residual activity
2-[[hydroxy(1-[[(2E)-3-(3-hydroxyphenyl)prop-2-enoyl]amino]ethyl)phosphoryl]methyl]pentanedioic acid
-
1 mM, 21% residual activity
2-[[hydroxy(1-[[(2E)-3-phenylprop-2-enoyl]amino]ethyl)phosphoryl]methyl]pentanedioic acid
-
1 mM, 50% residual activity
2-[[hydroxy(1-[[(3-nitrobenzyl)sulfonyl]amino]ethyl)phosphoryl]methyl]pentanedioic acid
-
1 mM, 52% residual activity
2-[[hydroxy(1-[[(3-nitrophenyl)sulfonyl]amino]ethyl)phosphoryl]methyl]pentanedioic acid
-
1 mM, 39% residual activity
2-[[hydroxy(1-[[(4-nitrobenzyl)sulfonyl]amino]ethyl)phosphoryl]methyl]pentanedioic acid
-
1 mM, 44% residual activity
2-[[hydroxy(2-methyl-1-[[(3-nitrobenzyl)sulfonyl]-amino]butyl)phosphoryl]methyl]pentanedioic acid
-
1 mM, 71% residual activity
2-[[hydroxy(2-methyl-1-[[(4-nitrobenzyl)sulfonyl]-amino]butyl)phosphoryl]methyl] pentanedioic acid
-
1 mM, 54% residual activity
2-[[hydroxy(2-methyl-1-[[(4-nitrobenzyl)sulfonyl]amino]propyl)phosphoryl]methyl] pentanedioic acid
-
1 mM, 29% residual activity
2-[[[1-[(1,3-benzodioxol-5-ylacetyl)amino]ethyl](hydroxy)phosphoryl]methyl]pentanedioic acid
-
1 mM, 12% residual activity; 1 mM, 42% residual activity; 1 mM, 60% residual activity
3-[(1-[[(benzyloxy)carbonyl]amino]ethyl)(hydroxy)phosphoryl]propanoic acid
-
1 mM, 50% residual activity
3-[hydroxy[1-([N-[(4-nitrobenzyl)sulfonyl]-D-alanyl]amino)ethyl]phosphoryl]propanoic acid
-
1 mM, 46% residual activity
3-[[1-[(1,3-benzodioxol-5-ylacetyl)amino]ethyl](hydroxy)phosphoryl]propanoic acid
-
1 mM, 35% residual activity
4-benzyloxycarbonylpiperidin-1-ium 4-methylbenzenesulfonate
-
-
ATP
-
above 10 mM
benzyl 1-(2-tert-butoxy-2-oxoethyl)piperidine-4-carboxylate
-
-
N-[(S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl]-1-[(S)-2-aminopropanoyl]piperidine-4-carboxamide
-
-
tert-butyl 4-formylpiperidine-1-carboxylate
-
-
tert-butyl 4-[(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)carbamoyl]piperidine-1-carboxylate
-
-
tert-butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate
-
-
tert-butyl [(S)-1-[4-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-ylcarbamoyl)piperidin-1-yl]-1-oxopropan-2-yl]carbamate
-
-
UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
above 10 mM
additional information
-
design and synthesise a small focused library of peptidomimetics as potential inhibitors of MurE from Staphylococcus aureus, overview
-