6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase, go to the full flat file.

Reaction

Synonyms

MuE, MurE, Synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase, uridine 5'-diphospho-N-acetylmuramoyl L-alanyl-D-glutamate:lysine ligase, Uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

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Results	in table
1	Activating Compound
1481	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
2	Cofactor
2	Crystallization (Commentary)
2	General Information
2	IC50 Value
48	Inhibitors
5	kcat/KM [mM/s]
20	KM Value [mM]
12	Metals/Ions
5	Natural Substrates/ Products (Substrates)
16	Organism
5	Pathway
4	PDB ID
5	pH Optimum
1	pH Range
2	pH Stability
1	pI Value
6	Protein Variants
6	Purification (Commentary)
1	Reaction
2	Reaction Type
14	Reference
4	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
19	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Turnover Number [1/s]

General Information

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General Information on EC 6.3.2.7 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

Staphylococcus aureus

Q2FZP6

the enzyme is involved in peptidoglycan biosynthesis and cell wall assembly

727964

additional information

Staphylococcus aureus

Q2FZP6

ATP-binding site structure and homology, overview. Asn407 makes a series of structurally important hydrogen bond interactions within the context of the architecture of the active site region

727964