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6.3.2.49: L-alanine-L-anticapsin ligase

This is an abbreviated version!
For detailed information about L-alanine-L-anticapsin ligase, go to the full flat file.

Word Map on EC 6.3.2.49

Reaction

ATP
+
L-alanine
 +
L-anticapsin
=
ADP
 +
phosphate
 +
bacilysin

Synonyms

alanine-anticapsin ligase, BacD, BL00235, BSU37710, EC 6.3.2.28, L-Ala-L-aniticapsin ligase, L-alanine-L-aniticapsin ligase, L-amino acid alpha-ligase, L-amino acid ligase, L-amino-acid ligase, LAL, LAL BL00235, RSp1486a, TabS, YwfE

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.49 L-alanine-L-anticapsin ligase

Engineering

Engineering on EC 6.3.2.49 - L-alanine-L-anticapsin ligase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
S1845A
no significant difference in kcat value between the wild type and the mutant enzyme. 2fold increase in Km-value for L-alanine
Y332A
-
site-directed mutagenesis, mutation of Trp332 to Ala causes the enzyme to hydrolyze ATP, even in the absence of L-Ala, and the structure of this mutant protein show a cavity in the N-terminal substrate-binding pocket
Y75F
no significant difference in kcat value between the wild type and the mutant enzyme, 2fold increase in KM-value for L-phenylalanine
S1845A
-
no significant difference in kcat value between the wild type and the mutant enzyme. 2fold increase in Km-value for L-alanine
-
Y75F
-
no significant difference in kcat value between the wild type and the mutant enzyme, 2fold increase in KM-value for L-phenylalanine
-
additional information