6.3.2.46: fumarate-(S)-2,3-diaminopropanoate ligase

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For detailed information about fumarate-(S)-2,3-diaminopropanoate ligase, go to the full flat file.

Reaction

Synonyms

DdaG, fumaroyl-2,3-diaminopropionate ligase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.46 fumarate-(S)-2,3-diaminopropanoate ligase

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Natural Substrates Products on EC 6.3.2.46 - fumarate-(S)-2,3-diaminopropanoate ligase

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ATP + fumarate + (2S)-2,3-diaminopropionate

AMP + diphosphate + (2E)-4-[(2-amino-2-carboxyethyl)amino]-4-oxobut-2-enoate

Pantoea agglomerans

E2JA32

the enzyme is involved in biosynthesis of dapdiamide antibiotics (a family of fumaramoyl- and epoxysuccinamoyl-dipeptides, named for the presence of 2,3-diaminopropionate (DAP) and the two amide linkages of the antibiotic scaffold)

729202