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6.3.2.45: UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase, go to the full flat file.

Reaction

ATP
+
UDP-N-acetyl-alpha-D-muramate
+
L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
=
ADP
+
phosphate
+
UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate

Synonyms

Mpl, murein peptide ligase, UDP-MurNAc:L-Ala-gamma-D-Glu-meso-A2pm ligase, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase, UDP-N-alpha-D-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (ADP-forming), yjfG

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.45 UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase

Reference

Reference on EC 6.3.2.45 - UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mengin-Lecreulx, D.; van Heijenoort, J.; Park, J.T.
Identification of the mpl gene encoding UDP-N-acetylmuramate:L-alanyl-gamma-glutamyl-meso-diaminopimelate ligase in Escherichia coli and its role in recycling of cell wall peptidoglycan
J. Bacteriol.
178
5347-5352
1996
Escherichia coli (P37773)
Manually annotated by BRENDA team
Herve, M.; Boniface, A.; Gobec, S.; Bianot, D.; Mengin-Lecreulx, D.
Biochemical characterization and physiological properties of Escherichia coli UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase
J. Bacteriol.
189
3987-3995
2007
Escherichia coli
Manually annotated by BRENDA team
Denoel, T.; Zervosen, A.; Lemaire, C.; Joris, B.; Herve, M.; Blanot, D.; Zaragoza, G.; Luxen, A.
Enantioselective synthesis of alpha-benzylated lanthionines and related tripeptides for biological incorporation into E. coli peptidoglycan
Org. Biomol. Chem.
12
9853-9863
2014
Escherichia coli
Manually annotated by BRENDA team