6.3.2.43: [amino group carrier protein]-L-2-aminoadipate ligase

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For detailed information about [amino group carrier protein]-L-2-aminoadipate ligase, go to the full flat file.

Reaction

Synonyms

alpha-aminoadipate-lysW ligase lysX, LysX, More, RimK-related lysine biosynthesis protein, Saci_0754, Tk0278, TkLysX/ArgX, TtLysX, [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate:L-2-aminoadipate ligase (ADP-forming), [lysine-biosynthesis-protein LysW]-L-2-aminoadipate ligase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.43 [amino group carrier protein]-L-2-aminoadipate ligase

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Results	in table
118	AA Sequence
4	Application
6	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
4	Expression
20	General Information
3	kcat/KM [mM/s]
3	KM Value [mM]
2	Metals/Ions
4	Natural Substrates/ Products (Substrates)
194	Organism
5	Pathway
1	pH Optimum
18	Protein Variants
5	Purification (Commentary)
4	Reaction
15	Reference
3	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
3	Subunits
24	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.3.2.43 - [amino group carrier protein]-L-2-aminoadipate ligase

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SYSTEMATIC NAME

IUBMB Comments

[amino group carrier protein]-C-terminal-L-glutamate:L-2-aminoadipate ligase (ADP-forming)

The enzymes from the thermophilic bacterium Thermus thermophilus and the thermophilic archaea Sulfolobus acidocaldarius and Sulfolobus tokodaii protect the amino group of L-2-aminoadipate by conjugation to the carrier protein LysW. This reaction is part of the lysine biosynthesis pathway in these organisms.