6.3.2.43: [amino group carrier protein]-L-2-aminoadipate ligase

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For detailed information about [amino group carrier protein]-L-2-aminoadipate ligase, go to the full flat file.

Reaction

an [amino group carrier protein]-C-terminal-L-glutamate

an [amino group carrier protein]-C-terminal-N-(1,4-dicarboxybutyl)-L-glutamine

Synonyms

alpha-aminoadipate-lysW ligase lysX, LysX, More, RimK-related lysine biosynthesis protein, Saci_0754, Tk0278, TkLysX/ArgX, TtLysX, [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate:L-2-aminoadipate ligase (ADP-forming), [lysine-biosynthesis-protein LysW]-L-2-aminoadipate ligase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.43 [amino group carrier protein]-L-2-aminoadipate ligase

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Results	in table
118	AA Sequence
4	Application
6	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
4	Expression
20	General Information
3	kcat/KM [mM/s]
3	KM Value [mM]
2	Metals/Ions
4	Natural Substrates/ Products (Substrates)
194	Organism
5	Pathway
1	pH Optimum
18	Protein Variants
5	Purification (Commentary)
4	Reaction
15	Reference
3	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
3	Subunits
24	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 6.3.2.43 - [amino group carrier protein]-L-2-aminoadipate ligase

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ATP + an [amino group carrier protein]-C-terminal-L-glutamate + L-2-aminoadipate

ADP + phosphate + an [amino group carrier protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine

Thermococcus kodakarensis

Q5JFW0

745351

ATP + [LysW]-C-terminal-L-glutamate + L-2-aminoadipate

ADP + phosphate + [LysW]-gamma-(L-2-aminoadip-2-yl)-L-glutamate

2 entries

ATP + [LysW]-C-terminal-L-glutamate54 + L-2-aminoadipate

ADP + phosphate + [LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate54

Thermus thermophilus

Q5SH23

the enzyme is involved in biosynthesis of lysine. LysX activates the gamma-carboxyl group of the C-terminal Glu54 of the 2-L-aminoaadipate carrier-protein LysW by phosphorylation, with concomitant conversion of ATP to ADP. LysX recognizes not only the C-terminal glutamate residue of LysW but also other portions, possibly the globular domain of LysW specifically

726024