Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

6.3.2.43: [amino group carrier protein]-L-2-aminoadipate ligase

This is an abbreviated version!
For detailed information about [amino group carrier protein]-L-2-aminoadipate ligase, go to the full flat file.

Reaction

ATP
+
an [amino group carrier protein]-C-terminal-L-glutamate
 +
L-2-aminoadipate
=
ADP
 +
phosphate
 +
an [amino group carrier protein]-C-terminal-N-(1,4-dicarboxybutyl)-L-glutamine

Synonyms

alpha-aminoadipate-lysW ligase lysX, LysX, More, RimK-related lysine biosynthesis protein, Saci_0754, Tk0278, TkLysX/ArgX, TtLysX, [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate:L-2-aminoadipate ligase (ADP-forming), [lysine-biosynthesis-protein LysW]-L-2-aminoadipate ligase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.43 [amino group carrier protein]-L-2-aminoadipate ligase

Engineering

Engineering on EC 6.3.2.43 - [amino group carrier protein]-L-2-aminoadipate ligase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
N264G/T265T
I185Y
site-directed mutagenesis, the mutant exhibits an apparent substrate preference for glutamate
N250G
site-directed mutagenesis, the mutant exhibits an apparent substrate preference for glutamate
S251F
site-directed mutagenesis, the mutant exhibits an apparent substrate preference for glutamate
Y175I
site-directed mutagenesis, the mutant exhibits an apparent substrate preference for glutamate
Y175I/I185Y/N250G/S251F
mutant exhibits an apparent substrate preference for glutamate
I185Y
-
site-directed mutagenesis, the mutant exhibits an apparent substrate preference for glutamate
-
S251F
-
site-directed mutagenesis, the mutant exhibits an apparent substrate preference for glutamate
-
Y175I
-
site-directed mutagenesis, the mutant exhibits an apparent substrate preference for glutamate
-
Y175I/I185Y/N250G/S251F
-
mutant exhibits an apparent substrate preference for glutamate
-
I185Y
-
site-directed mutagenesis, the mutant exhibits an apparent substrate preference for glutamate
-
S251F
-
site-directed mutagenesis, the mutant exhibits an apparent substrate preference for glutamate
-
Y175I
-
site-directed mutagenesis, the mutant exhibits an apparent substrate preference for glutamate
-
Y175I/I185Y/N250G/S251F
-
mutant exhibits an apparent substrate preference for glutamate
-
additional information