6.3.2.41: N-acetylaspartylglutamate synthase

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For detailed information about N-acetylaspartylglutamate synthase, go to the full flat file.

Reaction

Synonyms

N-acetylaspartylglutamate synthetase, N-acetylaspartylglutamate synthetase II, NAAG synthetase, NAAGS, NAAGS-II, RIMKLA, RIMKLB

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.41 N-acetylaspartylglutamate synthase

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2	Activating Compound
1028	AA Sequence
5	Cloned(Commentary)
4	Cofactor
10	KM Value [mM]
1	Localization
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
5	Organism
2	Pathway
2	pH Optimum
2	Purification (Commentary)
1	Reaction
1	Reaction Type
4	Reference
30	Source Tissue
2	Specific Activity [micromol/min/mg]
7	Substrates and Products (Substrate)
4	Subunits
16	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.3.2.41 - N-acetylaspartylglutamate synthase

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SYSTEMATIC NAME

IUBMB Comments

N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamate-forming)

The enzyme, found in animals, produces the neurotransmitter N-acetyl-L-aspartyl-L-glutamate. One isoform also has the activity of EC 6.3.1.17, beta-citrylglutamate synthase [2], while another isoform has the activity of EC 6.3.2.42, N-acetylaspartylglutamylglutamate synthase [3].