6.3.2.41: N-acetylaspartylglutamate synthase

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For detailed information about N-acetylaspartylglutamate synthase, go to the full flat file.

Reaction

Synonyms

N-acetylaspartylglutamate synthetase, N-acetylaspartylglutamate synthetase II, NAAG synthetase, NAAGS, NAAGS-II, RIMKLA, RIMKLB

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.41 N-acetylaspartylglutamate synthase

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2	Activating Compound
1028	AA Sequence
5	Cloned(Commentary)
4	Cofactor
10	KM Value [mM]
1	Localization
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
5	Organism
2	Pathway
2	pH Optimum
2	Purification (Commentary)
1	Reaction
1	Reaction Type
4	Reference
30	Source Tissue
2	Specific Activity [micromol/min/mg]
7	Substrates and Products (Substrate)
4	Subunits
16	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 6.3.2.41 - N-acetylaspartylglutamate synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

ATP + N-acetyl-L-aspartate + citrate

?

Mus musculus

Q6PFX8, Q80WS1

-

725404

-

-

?

ATP + N-acetyl-L-aspartate + L-glutamate

ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate

5 entries

ATP + N-acetyl-L-aspartate + L-glutamate

ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate

Mus musculus

-

-

725423, 727869

-

-

?

ATP + N-acetyl-L-aspartate + L-glutamate

ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate

Mus musculus

Q6PFX8, Q80WS1

-

725404

-

-

?

ATP + N-acetyl-L-aspartate + L-glutamate

ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate

Mus musculus

Q6PFX8, Q80WS1

isoform RIMKLA also catalyses the synthesis of beta-citryl-L-glutamate with an activity that is 75fold lower than its N-acetyl-L-aspartyl-L-glutamate synthase activity

725404

-

-

?

ATP + N-acetyl-L-aspartate + L-glutamate

ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate

Mus musculus

Q6PFX8, Q80WS1

isoform RIMKLB catalyses the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate at nearly equal rates, cf. EC 6.3.1.17, beta-citrylglutamate synthase

725404

-

-

?

ATP + N-acetyl-L-aspartate + L-glutamate

ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate

Rattus norvegicus

-

-

728179

-

-

?