6.3.2.38: N2-citryl-N6-acetyl-N6-hydroxylysine synthase
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For detailed information about N2-citryl-N6-acetyl-N6-hydroxylysine synthase, go to the full flat file.
Reaction
Synonyms
aerD, EC 6.3.2.27, iuacA, iucA, Nalpha-citryl-Nepsilon-acetyl-Nepsilon-hydroxylysine synthase
ECTree
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Systematic Name
Systematic Name on EC 6.3.2.38 - N2-citryl-N6-acetyl-N6-hydroxylysine synthase
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citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)
Requires Mg2+. The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme is believed to form an adenylate intermediate prior to ligation.