6.3.2.36: 4-phosphopantoate-beta-alanine ligase

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For detailed information about 4-phosphopantoate-beta-alanine ligase, go to the full flat file.

Reaction

Synonyms

Mhun_0832, phosphopantothenate synthetase, Pps, TK1686, TK1686 protein

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.36 4-phosphopantoate-beta-alanine ligase

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3	Activating Compound
1904	AA Sequence
3	Cloned(Commentary)
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1	Crystallization (Commentary)
7	General Information
2	Metals/Ions
2	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
5	Organism
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12	PDB ID
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2	Purification (Commentary)
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5	Reference
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5	Subunits
15	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 6.3.2.36 - 4-phosphopantoate-beta-alanine ligase

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(R)-4-phosphopantoate:beta-alanine ligase (AMP-forming)

The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 [pantoate---beta-alanine ligase] and EC 2.7.1.33 [pantothenate kinase], respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine. The two archaeal enzymes that catalyse this conversion are EC 2.7.1.169, pantoate kinase, and this enzyme.