6.3.2.35: D-alanine-D-serine ligase

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For detailed information about D-alanine-D-serine ligase, go to the full flat file.

Word Map on EC 6.3.2.35

6.3.2.35

vancomycin

enterococci

vancomycin-resistant

faecium

casseliflavus

gallinarum

faecalis

erythromycin

ampicillin

gentamicin

teicoplanin

ciprofloxacin

d-ala-d-ser

medicine

glycopeptide-resistant

linezolid

e-test

vitek

aph3\'-iiia

antimicrobial-resistant

Reaction

Synonyms

D-alanine:D-serine ligase, VanC2, vanC2/3, VanE, VanG, vanGCar, VanL

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.35 D-alanine-D-serine ligase

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2	AA Sequence
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2	Expression
8	General Information
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3	KM Value [mM]
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2	Natural Substrates/ Products (Substrates)
14	Organism
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Systematic Name on EC 6.3.2.35 - D-alanine-D-serine ligase

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D-alanine:D-serine ligase (ADP-forming)

The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine---D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.