6.3.2.3: glutathione synthase
This is an abbreviated version!
For detailed information about glutathione synthase, go to the full flat file.
Word Map on EC 6.3.2.3
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6.3.2.3
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gamma-glutamylcysteine
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dismutase
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gamma-glutamyl
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catalase
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s-transferase
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sulfoximine
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cadmium
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5-oxoprolinuria
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buthionine
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5-oxoproline
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hemolytic
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acidosis
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phytochelatins
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transpeptidase
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gamma-gcs
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school
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school-based
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pyroglutamic
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glutathione-related
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atp-grasp
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bullied
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l-buthionine-s,r-sulfoximine
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juncea
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6.3.2.2
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glutathione-deficient
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homoglutathione
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gsh-dependent
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medicine
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biotechnology
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synthesis
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analysis
- 6.3.2.3
- gamma-glutamylcysteine
- dismutase
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gamma-glutamyl
- catalase
- s-transferase
- sulfoximine
- cadmium
-
5-oxoprolinuria
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buthionine
- 5-oxoproline
-
hemolytic
- acidosis
- phytochelatins
- transpeptidase
- gamma-gcs
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school
-
school-based
-
pyroglutamic
-
glutathione-related
-
atp-grasp
-
bullied
-
l-buthionine-s,r-sulfoximine
- juncea
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6.3.2.2
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glutathione-deficient
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homoglutathione
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gsh-dependent
- medicine
- biotechnology
- synthesis
- analysis
Reaction
Synonyms
Asuc_1947, bifunctional glutathione synthetase, bifunctional GSH synthetase, bifunctional L-glutathione synthetase, gamma -glutamate-cysteine ligase-glutathione synthetase, gamma-GCS, gamma-GCS-GS, gamma-glutamate-cysteine ligase/glutathione synthetase, gamma-glutamylcysteine synthetase-glutathione synthetase, GCL, GCSGS, ghF, glutamate cysteine ligase, glutathione biosynthesis bifunctional protein GshAB, Glutathione synthase, Glutathione synthetase, Glutathione synthetase (tripeptide), GS, GSH synthase, GSH synthetase, GSH-S, GSH2, gshAB, GSHase, gshB, GshF, GshFAp, GshFAs, GSHII, GSHS, GSHS1, GSS, hGS, L-glutathione synthetase, More, Phytochelatin synthetase, StGCL-GS, Synthetase, glutathione, TAGS1, TaGS2, TbGS, ZmGS
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6.3.2.3 glutathione synthaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 6.3.2.3 - glutathione synthase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
adenosine-5'-tetraphospho-5'-pyridoxal
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when incubated with an adenosine-5'-polyphospho-5'-pyridoxal or pyridoxal phosphate in the presence of Mg2+ and then reduced with sodium borohydride, it is most rapidly inactivated by adenosine-5'-tetraphospho-5'-pyridoxal, addition of either ATP or gamma-glutamylcysteine protects from inactivation
c-jun
AF333982
negative regulation of enzyme expression by blocking the binding of AP-1 to the promotor
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L-buthionine-(S,R)-sulfoximine
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induction of enzyme expression at 0.01 mM
menadione
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wild-type cells are not able to grow on menadione containing substrate, but the recombinant strain is able to survive at 0.1 mM menadione, induction of enzyme expression by superoxide generation
tert-butylhydroquinone
AF333982
regulatory role, activator protein 1 AP-1-mediated induction of enzyme expression, 35fold increase in activity in recombinant H4IIE cells, induction of c-jun formation, which is a negative regulatory protein blocking the binding of activator protein 1 to the promotor
5,5'-dithiobis(2-nitrobenzoate)
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Cys289 is the only amino acid residue reactive with DTNB. Modification of Cys289 with DTNB results in complete loss of the catalytic activity
5,5'-dithiobis(2-nitrobenzoate)
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inhibition of ADP-ATP exchange reaction, no effect on tripeptide synthesis
ADP
product inhibition, competitive versus ATP, noncompetitive versus gamma-L-glutamyl-L-cysteine and glycine
ATP
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high concentrations inhibit the wild-type enzyme, while both nicked and loopless enzyme are not inhibited
buthionine sulfoximine
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reduces the GSH level and the GSH/GSSG ratio without altering GSSG levels in hearts, livers, and kidneys
Cd2+
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wild-type cells are not able to grow on cadmium chloride containing substrate, but the recombinant strain is able to survive at 1 mM cadmium chloride concentration, the wild-type can grow on 1 mM Cd2+ in presence of 20 mM GSH
glutathione
product inhibition, noncompetitive versus ATP, gamma-L-glutamyl-L-cysteine, and glycine
GSSG
the oxidised form of glutathione acts as an irreversible inhibitor of recombinant GshB
Hg2+
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wild-type cells are not able to grow on mercuric chloride containing substrate, but the recombinant strain is able to survive at 0.01 mM mercuric chloride concentration, the wild-type can grow on 0.01 mM Hg2+ in presence of 20 mM GSH
NEM
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inhibition of ADP-ATP exchange reaction, no effect on tripeptide synthesis
phosphate
product inhibition, noncompetitive versus ATP, gamma-L-glutamyl-L-cysteine, and glycine
additional information
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decrease of enzyme activity in hypoxia: 20% after 6 h, 17% after 12 h, 23% after 24 h, hypoxia-induced decrease in enzyme activity may be prevented by MAPK inhibition and catalase
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additional information
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no significant inhibition: amoxycillin, gentamycin, streptomycin, kanamycin, tetracycline, penicillin, artesunate, aablaquine and primaquine
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additional information
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enzyme expression in not affected by insulin and hydrocortisone treatment or by ethanol-feeding
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additional information
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no induction of enzyme expression by thioacetamide
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additional information
insensitive to feedback inhibition caused by GSH even at 20 mM
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