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6.3.2.26: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

This is an abbreviated version!
For detailed information about N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase, go to the full flat file.

Word Map on EC 6.3.2.26

Reaction

3 ATP +

L-2-aminohexanedioate
+
L-cysteine
 +
L-valine
 +
H2O
= 3 AMP + 3 diphosphate +
N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine

Synonyms

ACV synthetase, ACVS, DELTA-(alpha-aminoadipyl)cysteinylvaline synthetase, delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase, delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase, delta-(L-alpha-aminoadipyl-L-cysteinyl-D-valine synthetase), delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase, L-(alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase, L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase, L-delta-alpha-aminoadipoyl-L-cysteinyl-D-valine synthetase, phosphopantothenate synthetase, Pps, synthetase, delta-(alpha-aminoadipyl)cysteinylvaline, TK1686

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

Substrates Products

Substrates Products on EC 6.3.2.26 - N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O
3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
show the reaction diagram
6-oxopiperidine 2-carboxylic acid + L-cysteine + L-valine + ATP
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
show the reaction diagram
-
-
-
-
?
alpha-aminoadipic acid + L-valine + L-lysine + ?
L-delta-alpha-aminoadipyl-L-cysteinyl-D-valine + ?
show the reaction diagram
-
enzyme is a nonribosomal peptide synthetase (NRPS) able to form ribosome-independent peptide bonds
ACV
-
?
ATP + (R)-4-phosphopantoate + beta-alanine
AMP + diphosphate + (R)-4'-phosphopantothenate
show the reaction diagram
DL-valine + L-O-(methylserine) + L-2-aminohexanedioate + ATP
L-O-(methylserinyl)-D-valine + L-O-(methylserinyl)-D-valine + AMP + diphosphate
show the reaction diagram
-
-
-
-
?
L-2-aminoadipate + allylglycine + L-valine + ATP
L-delta-(aminoadipyl)-L-allylglycinyl-D-valine + AMP + diphosphate
show the reaction diagram
L-2-aminoadipate + L-cystathionine + L-valine + ATP
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
show the reaction diagram
-
-
-
-
?
L-2-aminoadipate + L-cysteine + L-allo-isoleucine + ATP
L-delta-(aminoadipyl)-L-cysteinyl-D-allo-isoleucine + AMP + diphosphate
show the reaction diagram
L-2-aminoadipate + L-cysteine + L-isoleucine + ATP
L-delta-(aminoadipyl)-L-cysteinyl-D-isoleucine + AMP + diphosphate
show the reaction diagram
-
-
-
-
?
L-2-aminoadipate + L-cysteine + L-valine + ATP
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
show the reaction diagram
L-2-aminoadipate + L-homocysteine + L-valine + ATP
N-(5-amino-5-carboxypentanoyl)-L-homocysteinyl-D-valine + AMP + diphosphate
show the reaction diagram
-
-
-
-
?
L-2-aminoadipate + vinylglycine + L-valine + ATP
L-delta-(aminoadipyl)-L-vinylglycinyl-D-valine + AMP + diphosphate
show the reaction diagram
L-glutamate + L-cysteine + L-valine + ATP
L-glutamyl-L-cysteinyl-D-valine + AMP + diphosphate
show the reaction diagram
-
-
-
-
?
S-carboxymethylcysteine + L-cysteine + L-valine + ATP
L-S-carboxymethylcysteinyl-L-cysteinyl-D-valine + AMP + diphosphate
show the reaction diagram
additional information
?
-