6.3.2.26: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

This is an abbreviated version!
For detailed information about N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase, go to the full flat file.

Word Map on EC 6.3.2.26

6.3.2.26

delta-l-alpha-aminoadipyl-l-cysteinyl-d-valine

penicillin

chrysogenum

clavuligerus

acremonium

beta-lactams

synthetases

tripeptide

nidulans

pcbab

cephalosporium

cephamycins

pantoate

gramicidin

epimerization

lld-acv

4'-phosphopantothenate

l-alpha-aminoadipic

non-ribosomal

kodakarensis

epsilon-aminotransferase

thiotemplate

tyrocidine

biotechnology

medicine

Reaction

3 ATP +

= 3 AMP + 3 diphosphate +

N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine

Synonyms

ACV synthetase, ACVS, DELTA-(alpha-aminoadipyl)cysteinylvaline synthetase, delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase, delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase, delta-(L-alpha-aminoadipyl-L-cysteinyl-D-valine synthetase), delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase, L-(alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase, L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase, L-delta-alpha-aminoadipoyl-L-cysteinyl-D-valine synthetase, phosphopantothenate synthetase, Pps, synthetase, delta-(alpha-aminoadipyl)cysteinylvaline, TK1686

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

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Results	in table
76	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
17	Cofactor
7	General Information
1	General Stability
23	Inhibitors
12	KM Value [mM]
2	Localization
10	Metals/Ions
14	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
35	Organism
4	Pathway
8	PDB ID
5	pH Optimum
2	pH Range
2	pH Stability
1	Posttranslational Modification
2	Protein Variants
8	Purification (Commentary)
1	Reaction
3	Reaction Type
33	Reference
1	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
50	Substrates and Products (Substrate)
6	Subunits
25	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
11	Temperature Stability [°C]
2	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 6.3.2.26 - N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

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4-phosphopantoate

Thermococcus kodakarensis

Q5JIZ8

substrate inhibition

727436

5,5'-dithiobis-2-nitrobenzoate

2 entries

AMP

Streptomyces clavuligerus

5 mM

440081

ATP

2 entries

bis-delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine

Penicillium chrysogenum

440084

D-glucose

Acremonium chrysogenum

crude extract is inhibited due to deprivation of ATP via sugar metabolism

440078

diphosphate

Streptomyces clavuligerus

5 mM

440081

dithiothreitol

Penicillium chrysogenum

440084

EDTA

Streptomyces clavuligerus

10 mM

440081

glyceraldehyde

2 entries

glyceraldehyde-3-phosphate

iodoacetamide

N-ethylmaleimide

phosphate

ACVS activity decreases 30% in the presence of 100 mM phosphate, being also affected by AMP and pyrophosphate, products of ATP hydrolysis

700004

pyridoxal 5'-phosphate

Streptomyces clavuligerus

2 mM

440081

additional information

4 entries