6.3.2.26: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

This is an abbreviated version!
For detailed information about N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase, go to the full flat file.

Reaction

3 ATP +

Synonyms

ACV synthetase, ACVS, DELTA-(alpha-aminoadipyl)cysteinylvaline synthetase, delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase, delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase, delta-(L-alpha-aminoadipyl-L-cysteinyl-D-valine synthetase), delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase, L-(alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase, L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase, L-delta-alpha-aminoadipoyl-L-cysteinyl-D-valine synthetase, phosphopantothenate synthetase, Pps, synthetase, delta-(alpha-aminoadipyl)cysteinylvaline, TK1686

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

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Results	in table
76	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
17	Cofactor
7	General Information
1	General Stability
23	Inhibitors
12	KM Value [mM]
2	Localization
10	Metals/Ions
14	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
35	Organism
4	Pathway
8	PDB ID
5	pH Optimum
2	pH Range
2	pH Stability
1	Posttranslational Modification
2	Protein Variants
8	Purification (Commentary)
1	Reaction
3	Reaction Type
33	Reference
1	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
50	Substrates and Products (Substrate)
6	Subunits
25	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
11	Temperature Stability [°C]
2	Turnover Number [1/s]

Cloned

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Cloned on EC 6.3.2.26 - N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

ACVS of Streptomyces lactamdurans is produced as a recombinant protein from a Streptomyces lividans transformant, carrying the pcbAB gene

Actinomyces sp.

-

700004

expression in Escherichia coli

Aspergillus nidulans

-

440075

expression in Hansenula polymorpha, co-expression with Bacillus subtilis sfp gene encoding a phosphopantetheinyl transferase that activated ACVS

Penicillium chrysogenum

-

706449

expression in Saccharomyces cerevisiae

Penicillium chrysogenum

-

705518

gene pcbAB

Penicillium chrysogenum

B6HLU1

726783

gene pcbAB, expression of plasmid p43gdh-ACVSthio encoding the sequence encoding the ACVS thiesterase gene domain, using the Aspergillus awamori gdh gene promoter plus the pcbAB gene transcriptional terminator, in Penicillium chrysogenum protoplasts

Penicillium chrysogenum

B6HLU1

727108

overexpressed in Escherichoa coli

Thermococcus kodakarensis

Q5JIZ8

727436

overexpression in Streptomyces lividans

Amycolatopsis lactamdurans

-

440082